Table of Contents Author Guidelines Submit a Manuscript
Journal of Ophthalmology
Volume 2017, Article ID 7174540, 5 pages
https://doi.org/10.1155/2017/7174540
Research Article

Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study

1Ophthalmology Department, Asociación para Evitar la Ceguera en México IAP, Mexico City, Mexico
2Retina Department, Asociación para Evitar la Ceguera en México IAP, Mexico City, Mexico

Correspondence should be addressed to Guillermo Salcedo-Villanueva; moc.liamg@allivodeclas

Received 28 July 2017; Revised 16 September 2017; Accepted 25 September 2017; Published 9 October 2017

Academic Editor: Giuseppe Querques

Copyright © 2017 David Berrones et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Maram, S. Srinivas, and S. R. Sadda, “Evaluating ocular blood flow,” Indian Journal of Ophthalmology, vol. 65, pp. 337–346, 2017. View at Publisher · View at Google Scholar
  2. K. Sambhav, S. Grover, and K. V. Chalam, “The application of optical coherence tomography angiography in retinal diseases,” Survey of Ophthalmology, 2017. View at Publisher · View at Google Scholar
  3. H. Sperling, M. C. Michel, and H. Rubben, “Sildenafil (Viagra®). Tolerance, contraindications, drug interactions,” Der Urologe, vol. 38, pp. 124–127, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. M. M. Moschos and E. Nitoda, “Pathophysiology of visual disorders induced by phosphodiesterase inhibitors in the treatment of erectile dysfunction,” Drug Design, Development and Therapy, vol. 8, pp. 3407–3413, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Almuhtaseb, O. Kanavati, and A. Lotery, “Branch retinal vein occlusion secondary to sildenafil,” BMJ, vol. 356, p. j753, 2017. View at Publisher · View at Google Scholar
  6. R. Gerometta, L. J. Alvarez, and O. A. Candia, “Effect of sildenafil citrate on intraocular pressure and blood pressure in human volunteers,” Experimental Eye Research, vol. 93, pp. 103–107, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. F. W. Fraunfelder and F. T. Fraunfelder, “Central serous chorioretinopathy associated with sildenafil,” Retina, vol. 28, pp. 606–609, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Damar, Y. Toklu, A. Tuncel et al., “Does therapeutic dose of sildenafil citrate treatment lead to central serous chorioretinopathy in patients with erectile dysfunction?” American Journal of Men's Health, vol. 7, pp. 439–443, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Stockman, L. T. Sharpe, A. Tufail, P. D. Kell, C. Ripamonti, and G. Jeffery, “The effect of sildenafil citrate (Viagra®) on visual sensitivity,” Journal of Vision, vol. 7, p. 4, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Martins, B. Kolomiets, R. Caplette et al., “Sildenafil acutely decreases visual responses in ON and OFF retinal ganglion cells,” Investigative Opthalmology & Visual Science, vol. 56, pp. 2639–2648, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Y. Kim, R. H. Silverman, R. V. Chan et al., “Measurement of choroidal perfusion and thickness following systemic sildenafil (Viagra®),” Acta Ophthalmologica, vol. 91, pp. 183–188, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. S. K. Vance, Y. Imamura, and K. B. Freund, “The effects of sildenafil citrate on choroidal thickness as determined by enhanced depth imaging optical coherence tomography,” Retina, vol. 31, pp. 332–335, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Kurtulan, A. Gulcu, M. Secil, I. Celebi, G. Aslan, and A. A. Esen, “Effects of sildenafil on ocular perfusion demonstrated by color Doppler ultrasonography,” International Journal of Impotence Research, vol. 16, pp. 244–248, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Koksal, H. Ozdemir, S. Kargi et al., “The effects of sildenafil on ocular blood flow,” Acta Ophthalmologica Scandinavica, vol. 83, pp. 355–359, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. Z. Yuan, T. W. Hein, R. H. Rosa Jr., and L. Kuo, “Sildenafil (Viagra) evokes retinal arteriolar dilation: dual pathways via NOS activation and phosphodiesterase inhibition,” Investigative Ophthalmology & Visual Science, vol. 49, pp. 720–725, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Harris, L. Kagemann, R. Ehrlich, Y. Ehrlich, C. R. Lopez, and V. A. Purvin, “The effect of sildenafil on ocular blood flow,” British Journal of Ophthalmology, vol. 92, pp. 469–473, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. J. K. Luu, A. V. Chappelow, T. J. McCulley, and M. F. Marmor, “Acute effects of sildenafil on the electroretinogram and multifocal electroretinogram,” American Journal of Ophthalmology, vol. 132, pp. 388–394, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. S. O. Dündar, A. Topalo Gcaron Lu, M. Dündar, and I. Koçak, “Effects of sildenafil on blue-on-yellow and white-on-white Humphrey perimetry in 3 months regular use,” Eye, vol. 20, pp. 810–813, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. T. I. Metelitsina, J. E. Grunwald, J. C. DuPont, and G. S. Ying, “Effect of Viagra on the foveolar choroidal circulation of AMD patients,” Experimental Eye Research, vol. 81, pp. 159–164, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. A. P. Costa, A. M. Lima, L. H. da Silva, R. de Oliveira Alves Carvalho, A. V. do Amaral, and N. C. Borges, “Ocular perfusion pressure and color Doppler imaging of the external ophthalmic artery of rabbits treated with sildenafil citrate,” BMC Veterinary Research, vol. 12, p. 149, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Jia, S. T. Bailey, D. J. Wilson et al., “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology, vol. 121, pp. 1435–1444, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Moult, W. Choi, N. K. Waheed et al., “Ultrahigh-speed swept-source OCT angiography in exudative AMD,” Ophthalmic Surgery, Lasers and Imaging Retina, vol. 45, pp. 496–505, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. M. M. Castillo, G. Mowatt, A. Elders et al., “Optical coherence tomography for the monitoring of neovascular age-related macular degeneration: a systematic review,” Ophthalmology, vol. 122, pp. 399–406, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Y. Kim, J. Fingler, R. J. Zawadzki et al., “Optical imaging of the chorioretinal vasculature in the living human eye,” Proceedings of the National Academy of Sciences, vol. 110, pp. 14354–14359, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Takase, M. Nozaki, A. Kato, H. Ozeki, M. Yoshida, and Y. Ogura, “Enlargement of foveal avascular zone in diabetic eyes evaluated by en face optical coherence tomography angiography,” Retina, vol. 35, pp. 2377–2383, 2015. View at Publisher · View at Google Scholar
  26. G. Coscas, M. Lupidi, and F. Coscas, “Optical coherence tomography angiography in diabetic maculopathy,” Developments in Ophthalmology, vol. 60, pp. 38–49, 2017. View at Publisher · View at Google Scholar
  27. A. Nagiel, S. R. Sadda, and D. Sarraf, “A promising future for optical coherence tomography angiography,” JAMA Ophthalmology, vol. 133, pp. 629-630, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. E. Rahimy, D. Sarraf, M. L. Dollin, J. D. Pitcher, and A. C. Ho, “Paracentral acute middle maculopathy in nonischemic central retinal vein occlusion,” American Journal of Ophthalmology, vol. 158, pp. 372–380 e1, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. R. F. Spaide, J. M. Klancnik Jr., and M. J. Cooney, “Retinal vascular layers in macular telangiectasia type 2 imaged by optical coherence tomographic angiography,” JAMA Ophthalmology, vol. 133, pp. 66–73, 2015. View at Publisher · View at Google Scholar · View at Scopus
  30. N. V. Palejwala, Y. Jia, S. S. Gao et al., “Detection of nonexudative choroidal neovascularization in age-related macular degeneration with optical coherence tomography angiography,” Retina, vol. 35, pp. 2204–2211, 2015. View at Publisher · View at Google Scholar
  31. L. Roisman, Q. Zhang, R. K. Wang et al., “Optical coherence tomography angiography of asymptomatic neovascularization in intermediate age-related macular degeneration,” Ophthalmology, vol. 123, pp. 1309–1319, 2016. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Querques, M. Srour, N. Massamba et al., “Functional characterization and multimodal imaging of treatment-naïve “quiescent” choroidal neovascularization,” Investigative Ophthalmology & Visual Science, vol. 54, pp. 6886–6892, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. J. D. Gass, “Serous retinal pigment epithelial detachment with a notch. A sign of occult choroidal neovascularization,” Retina, vol. 4, pp. 205–220, 1984. View at Publisher · View at Google Scholar
  34. L. Toto, E. Borrelli, L. Di Antonio, P. Carpineto, and R. Mastropasqua, “Retinal vascular plexuses’ changes in dry age-related macular degeneration, evaluated by means of optical coherence tomography angiography,” Retina, vol. 36, pp. 1566–1572, 2016. View at Publisher · View at Google Scholar · View at Scopus
  35. D. J. Coleman, R. H. Silverman, M. J. Rondeau, H. O. Lloyd, A. A. Khanifar, and R. V. Chan, “Age-related macular degeneration: choroidal ischaemia?” British Journal of Ophthalmology, vol. 97, pp. 1020–1023, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. R. W. Flower, C. von Kerczek, L. Zhu, A. Ernest, C. Eggleton, and L. D. Topoleski, “Theoretical investigation of the role of choriocapillaris blood flow in treatment of subfoveal choroidal neovascularization associated with age-related macular degeneration,” American Journal of Ophthalmology, vol. 132, pp. 85–93, 2001. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Okamoto, M. Yamashita, T. Sakamoto, and N. Ogata, “Choroidal blood flow and thickness as predictors for response to anti-vascular endothelial growth factor therapy in macular edema secondary to branch retinal vein occlusion,” Retina, 2017. View at Publisher · View at Google Scholar
  38. B. Lee, E. A. Novais, N. K. Waheed et al., “En face Doppler optical coherence tomography measurement of total retinal blood flow in diabetic retinopathy and diabetic macular edema,” JAMA Ophthalmology, vol. 135, p. 244, 2017. View at Publisher · View at Google Scholar
  39. M. Nicolo, R. Rosa, D. Musetti, M. Musolino, M. Saccheggiani, and C. E. Traverso, “Choroidal vascular flow area in central serous chorioretinopathy using swept-source optical coherence tomography angiography,” Investigative Ophthalmology & Visual Science, vol. 58, p. 2002, 2017. View at Publisher · View at Google Scholar