Switching to Aflibercept in Diabetic Macular Edema Not Responding to Ranibizumab and/or Intravitreal Dexamethasone Implant

Table 3

Anatomical outcomes: central retinal thickness before any intravitreal injection (baseline) and before and after switch to aflibercept at M3 and M6.

	Baseline	Preswitch	M3 postswitch	M6 postswitch
Number of eyes	25	25	25	25
Mean CRT in μm (SD)	532 (186.2)	470.8 (129.9)	315.6 (89.7)	303.3 (59.1)
F	21.47
value (ANOVA test)	0.0013
Mean CRT change from preswitch in μm (SD)			−155.2 (144.7)	−167.5 (149.3)
value (compared to preswitch CRT)			<0.0001	<0.0001
Mean CRT change from baseline in μm (SD)		−61.2 (176)	−216.4 (226.1)	−228.7 (212.2)
value (compared to baseline CRT)		0.07	<0.0001	<0.0001

CRT: central retinal thickness; F: result of variance test (ordinary one-way ANOVA). Except for ANOVA test, values were obtained after a paired parametric t-test after verification that the distribution was normal. <0.01 and <0.0001.