Diagnostic Ability of Retinal Nerve Fiber Layer Thickness Deviation Map for Localized and Diffuse Retinal Nerve Fiber Layer Defects
Table 2
Area under ROC curve and sensitivities at fixed specificities for RNFL deviation map and circumpapillary RNFL parameters.
Normal eyes ()
Eyes with localized RNFL defects ()
AUCs (95% CI)
Sn/Sp (Sp ≥ 90%)
Eyes with diffuse RNFL defects ()
AUCs (95% CI)
Sn/Sp (Sp ≥ 90%)
RNFL defect area measurements in deviation map (mm2)
Red-coded
1.15 ± 0.81
0.991† (0.969–0.999)
97/90
4.04 ± 2.16
1.000† (0.984–1.000)
100/100
0.216
Circumpapillary RNFL thickness parameters (μm)
Average
99.2 ± 6.1
88.1 ± 6.6
0.894 (0.846–0.931)
68/90
72.2 ± 9.7
0.986† (0.961–0.997)
97/96
<0.001
Quadrant
Temporal
73.7 ± 8.4
64.4 ± 10.2
0.784 (0.725–0.836)
57/90
56.1 ± 9.9
0.911 (0.867–0.944)
77/90
0.004
Superior
124.4 ± 10.8
104.2 ± 14.8
0.854 (0.801–0.897)
65/90
87.1 ± 20.5
0.941 (0.902–0.967)
85/90
0.015
Nasal
70.4 ± 8.6
65.3 ± 7.9
0.676 (0.611–0.736)
25/90
63.5 ± 9.7
0.713 (0.651–0.770)
34/91
0.504
Inferior
127.8 ± 12.1
100.6 ± 16.0
0.914† (0.870–0.947)
79/92
79.7 ± 22.2
0.959 (0.925–0.980)
87/92
0.138
Clock-hour
9
57.8 ± 7.7
53.8 ± 8.1
0.660 (0.594–0.721)
19/92
49.2 ± 9.2
0.764 (0.705–0.817)
45/92
0.060
10
85.2 ± 12.2
72.9 ± 13.8
0.768 (0.707–0.821)
42/90
61.6 ± 15.7
0.879 (0.831–0.918)
67/90
0.019
11
134.4 ± 18.3
107.5 ± 23.2
0.817 (0.761–0.865)
53/90
84.8 ± 29.6
0.916 (0.873–0.948)
79/90
0.016
12
125.9 ± 20.2
106.5 ± 24.8
0.720 (0.657–0.778)
35/90
91.1 ± 26.0
0.847 (0.794–0.890)
62/90
0.012
1
112.8 ± 18.8
98.5 ± 20.3
0.708 (0.644–0.766)
34/92
85.3 ± 20.2
0.836 (0.783–0.881)
62/90
0.012
2
85.1 ± 13.7
79.1 ± 12.9
0.617 (0.550–0.681)
21/90
73.9 ± 15.0
0.729 (0.668–0.785)
42/90
0.045
3
61.3 ± 9.7
57.2 ± 9.5
0.629 (0.563–0.692)
23/90
58.7 ± 10.0
0.567 (0.501–0.631)
24/90
0.296
4
64.9 ± 10.5
59.5 ± 9.4
0.653 (0.588–0.715)
19/90
58.0 ± 10.5
0.684 (0.620–0.742)
28/90
0.582
5
99.2 ± 14.8
86.6 ± 14.8
0.730 (0.667–0.786)
39/90
74.1 ± 17.2
0.880 (0.831–0.918)
69/91
0.002
6
136.3 ± 20.9
106.1 ± 22.9
0.844 (0.790–0.889)
60/90
83.4 ± 31.8
0.905 (0.860–0.939)
80/100
0.138
7
147.9 ± 17.2
109.4 ± 27.0
0.880 (0.830–0.919)
68/95
81.7 ± 31.0
0.959 (0.925–0.981)
87/93
0.011
8
78.0 ± 12.0
66.5 ± 16.0
0.737 (0.675–0.793)
47/90
57.4 ± 14.5
0.865 (0.814–0.906)
63/91
0.012
0.002†
0.249†
Comparison of AUCs by the method of DeLong et al. †Comparison of highest AUCs between circumpapillary RNFL thickness and RNFL defect area measurements in deviation map. ROC: receiver operating characteristic; RNFL: retinal nerve fiber layer; AUC: area under receiver operating characteristic curve; CI: confidence interval; Sn: sensitivity; Sp: specificity.
