Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema

Table 2

Multivariate associations of retinal layer thickness and reflectance ratio with logMAR visual acuity based on data from DME subjects (N = 28).

Metrics	Thickness (microns), mean ± SD	Regression coefficient (95% CI) [1]
NFLT	21 ± 6	0.074 (−0.020, 0.167)
GCLIPLT	43 ± 26	0.030 (0.013, 0.048)
INLT	55 ± 57	0.014 (0.003, 0.024)
OPLT	24 ± 8	0.101 (0.043, 0.160)
ONLT	159 ± 57	−0.007 (−0.018, 0.003)
OSLT	42 ± 9	−0.117 (−0.165, −0.069)
Metrics	Reflectance ratio, mean ± SD	Regression coefficient (95% CI) [1]
NFLR	0.63 ± 0.12	0.077 (0.040, 0.114)
GCLIPLR	0.65 ± 0.07	0.085 (−0.003, 0.173)
INLR	0.49 ± 0.08	−0.028 (−0.123, 0.068)
OPLR	0.53 ± 0.08	0.057 (−0.035, 0.150)
ONLR	0.35 ± 0.04	0.012 (−0.130, 0.154)
OSLR	0.76 ± 0.11	−0.069 (−0.117, −0.021)

. ¹Regression coefficients represent logMAR change with 10 micron increase in thickness or 0.1 increase in reflectance ratio, after adjusting for age, sex, race, diabetes type, diabetes duration, and HbA1c. NFL = nerve fiber layer; GCLIPL = ganglion cell layer + inner plexiform layer; INL = inner nuclear layer; OPL = outer plexiform layer; ONL = outer nuclear layer; OSL = photoreceptor outer segment layer; RPE = retinal pigment epithelium. Suffix T = thickness; suffix R = reflectance ratio.