Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema

Table 4

Multivariate associations of retinal layer thickness and reflectance ratio with logMAR visual acuity based on data from subjects without DME but with a history of anti-VEGF treatment (N = 25).

Metrics	Thickness (microns), mean ± SD	Regression coefficient (95% CI) [1]
NFLT	18 ± 3	0.132 (−0.054, 0.318)
GCLIPLT	29 ± 11	0.012 (−0.034, 0.057)
INLT	28 ± 10	0.046 (0.007, 0.086)
OPLT	21 ± 12	0.061 (0.028, 0.093)
ONLT	117 ± 39	−0.009 (−0.02, 0.002)
OSLT	41 ± 8	−0.021 (−0.078, 0.036)
Metrics	Reflectance ratio, mean ± SD	Regression coefficient (95% CI) [1]
NFLR	0.55 ± 0.09	0.031 (−0.037, 0.098)
GCLIPLR	0.61 ± 0.08	0.017 (−0.056, 0.09)
INLR	0.49 ± 0.07	−0.002 (−0.079, 0.076)
OPLR	0.51 ± 0.07	−0.014 (−0.09, 0.061)
ONLR	0.38 ± 0.06	0.01 (−0.068, 0.088)
OSLR	0.79 ± 0.07	0.003 (−0.079, 0.085)

. ¹Regression coefficients represent logMAR change with 10 micron increase in thickness or 0.1 increase in reflectance ratio, after adjusting for age, sex, race, diabetes type, diabetes duration, and HbA1c. NFL = nerve fiber layer; GCLIPL = ganglion cell layer + inner plexiform layer; INL = inner nuclear layer; OPL = outer plexiform layer; ONL = outer nuclear layer; OSL = photoreceptor outer segment layer; RPE = retinal pigment epithelium. Suffix T = thickness; suffix R = reflectance ratio.