Research Article
Corneal Debridement Combined with Intrastromal Voriconazole for Recalcitrant Fungal Keratitis
Table 1
Presentation and final outcome of cases with recalcitrant fungal keratitis that received intrastromal voriconazole combined with debridement.
| Number | Size of infiltrate (mm) | Size of ulcer (mm) | Location | Depth (μm) | Initial BCVA | Organism isolated | Sensitivity of Vori | Inhibition zone (mm) | Intervention | Residual depth (μm) | Duration for healing (d) | NV | Final BCVA | Astig (D) |
| 1 | 5.0 | 3.0 | Peripheral | 392 | 20/100 | Fusarium | R | 0 | INJ = 1 | 324 | 9 | Y | 20/25 | 1.0 | 2 | 4.5 | 3.0 | Paracentral | 280 | 20/160 | Fusarium | I | 12 | INJ = 1 | 408 | 13 | N | 20/25 | 1.75 | 3 | 5.5 | 4.0 | Central | 320 | 20/200 | Fusarium | S | 28 | INJ = 2 | 392 | 20 | N | 20/32 | 1.0 | 4 | 6.0 | 4.0 | Paracentral | 332 | 20/63 | Fusarium | S | 22 | INJ = 2 | 365 | 22 | N | 20/20 | 0 | 5 | 7.0 | 4.0 | Paracentral | 350 | LP | Fusarium | R | 10 | INJ = 2 | 500 | 24 | Y | LP | — | 6 | 3.5 | 2.0 | Peripheral | 188 | 20/40 | Alternaria | S | 21 | INJ = 1 | 476 | 10 | N | 20/25 | 0 | 7 | 8.0 | 5.0 | Paracentral | 392 | 20/2000 | Fusarium | S | 18 | INJ = 2 | 340 | 14 | Y | 20/50 | 1.5 | 8 | 5.0 | 3.0 | Peripheral | 270 | 20/2000 | Fusarium | S | 18 | INJ = 1 | 456 | 11 | Y | 20/32 | 2.0 | 9 | 4.0 | 2.0 | Peripheral | 236 | 20/50 | Alternaria | S | 21 | INJ = 1 | 500 | 7 | Y | 20/25 | 0.5 | 10 | 6.5 | 4.0 | Paracentral | 344 | 20/80 | Fusarium | S | 23 | INJ = 2 | 383 | 28 | N | 20/32 | 0 | 11 | 5.5 | 3.5 | Paracentral | 348 | 20/160 | Fusarium | R | 0 | INJ = 1 | 329 | 9 | N | 20/32 | 2.0 | 12 | 4.5 | 2.5 | Paracentral | 300 | 20/63 | Fusarium | I | 12 | INJ = 1 | 358 | 8 | N | 20/25 | 1.0 | 13 | 7.5 | 5.5 | Paracentral | 360 | 20/63 | Alternaria | S | 15 | INJ = 2 | 334 | 25 | Y | 20/25 | 1.0 | 14 | 5.0 | 3.0 | Paracentral | 304 | 20/100 | Fusarium | R | 0 | INJ = 3, LKP | — | 32 | — | 20/25 | 3.0 |
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BCVA: best-corrected visual acuity; LP: light projection; Vori: voriconazole; R: resistance; I: intermediary; S: sensitive; INJ: number of intrastromal voriconazole injection; NV: neovascularization; Astig: astigmatism.
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