Journal of Ophthalmology

Review Article

Biomaterial Influence on Intraocular Lens Performance: An Overview

Table 1

Posterior capsule opacification (PCO) and neodymium:YAG (Nd:YAG) rates of several scientific articles published between 2000 and 2014.
AuthorsIOL modelIOL characteristicsEyes (n)Study designFollow-upPCO rates (%) valueNd:YAG rates value
Kucuksumer et al. [29]Acrysof MA60BM (Alcon)3-piece, hydrophobic acrylic32Contralateral & randomized study1 year93.7% grade 0
6.3% grade 1		<0.0010%—
MemoryLens3-piece, hydrophilic acrylic3240.6% grade 0
28.1 grade 1
25% grade 2
6.3% grade 3		0%
Acrysof MA60BM (Alcon)3-piece, hydrophobic acrylic21Contralateral & randomized study3 years80.9% grade 0
14.4% grade 1
4.7% grade 2		<0.050%0.46
MemoryLens3-piece, hydrophilic acrylic214.7% grade 0
52.4% grade 1
19% grade 2
9.5% grade 3
14.4% grade 4		19%
Oner et al. [33]Acrysof MA30BA (Alcon)3-piece, rectangular-edge hydrophobic acrylic80Consecutive series16–22 months8.70%<0.0514.30%—
Opsia-Agena 550Round-edge, PMMA7724.70%26.30%
Hayashi et al. [39]MZ60BD (Alcon)Single-piece, PMMA90Prospective & randomized studyUp to 2 years—<0.000128.90%—
SI-30NB (AMO)Silicone83—14.40%
Acrysof MA60BM (Alcon)3-piece, hydrophobic acrylic96—4.20%
Schauersberger et al. [44]Acrysof (Alcon)3-piece, square-edge, hydrophobic acrylic25Prospective study3 years85% grade 0
15% grade 1		0.323——
CeeOn 911A (AMO)3-piece, square-edge, silicone2595% grade 0
5% grade 1		—
Abhilakh Missier et al. [19]AcrySof MA30BA/MA60BM (Alcon)3-piece, hydrophobic acrylic107Retrospective & contralateral study3 years19.6% grade 0
53.3% grade 1
16.8% grade 2
10.3% grade 3		<0.00012.8%<0.05
AA4203VF (Staar)Plate haptic, silicone1076.5% grade 0
26.2% grade 1
22.4% grade 2
44.9% grade 3		23.1%
Bender et al. [21]812A/Storz P497UV (Pharmacia)PMMA63Retrospective study6 months21.9%/27.2%<0.0001——
AcrySof MA30/SA31 (Alcon)3-piece/1-piece, hydrophobic acrylic3310.5%/6.2%
SI-31 (AMO)Silicone2215.30%
Hydroview H61 (B&L)Hydrophilic acrylic2265.00%
812A/Storz P497UV (Pharmacia)1-piece, PMMA63Retrospective study2 years32.9%/45.5%——
AcrySof MA30/SA31 (Alcon)3-piece/1-piece, hydrophobic acrylic3317.8%/18.4%
SI-31 (AMO)Silicone2217.80%
Hydroview H61 (B&L)Hydrophilic acrylic2262.20%
Prosdocimo et al. [42]CeeOn Edge (AMO)3-piece, sharp-edge, silicone40Prospective study18 months10% without VA lost0.03360%—
Acrysof (Alcon)3-piece, square sharp-edge, hydrophobic acrylic3829% without VA lost
3% with VA lost		3%
Auffarth et al. [20]—Hydrophilic acrylic294Retrospective study3 years37%<0.00131.10%<0.001
—PMMA38428.30%19.30%
—Hydrophobic acrylic4218.90%7.10%
—Silicone42621.60%16.20%
K. Hayashi and H. Hayashi [26]Hydroview H60M (B&L)3-piece, hydrophilic acrylic95Prospective randomized contralateral study24 months——28%<0.0001
Acrysof MA60BM (Alcon)3-piece, hydrophobic acrylic95—2%
Heatley et al. [27]Centerflex 570H (Rayner)Single-piece, square-edge, hydrophilic acrylic53Prospective randomized contralateral study1 year50.30%<0.0012.60%—
AcrySof SA60AT (Alcon)Single-piece, square-edge, hydrophobic acrylic534.90%0%
Kugelberg et al. [30]BL27 (B&L)Single-piece, square-edge, hydrophilic acrylic60Prospective randomized study1 year18.20%<0.0013.50%>0.05
AcrySof SA60AT (Alcon)Single-piece, square-edge, hydrophobic acrylic604.65%6.80%
Hancox et al. [13]AcrySof SN60AT (Alcon)1-piece, hydrophobic acrylic36Prospective randomized contralateral study24 months8.83%<0.0001——
AF-1 YA-60BB (Hoya)Hydrophobic acrylic3632.44%
Hayashi et al. [40]Acrysof MA60AC (Alcon)3-piece, round optic, hydrophobic acrylic45Prospective randomized contralateral study12 months—0.50042.20%>0.999
AR40e (AMO)3-piece, round optic, hydrophobic acrylic45—2.20%
Kohnen et al. [41]CeeOn Edge 911A (AMO) versus Acrysof MA60BM (Alcon)Sharp-edge, silicone versus sharp-edge, hydrophobic acrylic139Prospective randomized contralateral study37 months——2.1% versus 2.1% 
CeeOn Edge 911A (AMO) versus PhacoFlex SI40NBSharp-edge, silicone versus round optic edge, silicone108—5.7% versus 17% 
Kugelberg et al. [31]BL27 (B&L)Hydrophlic acrylic60Prospective randomized study2 years——42%<0.001
AcrySof SA60AT (Alcon)Hydrophobic acrylic60—10%
Boureau et al. [23]AcrySof SA60AT (Alcon)1-piece, sharp-edge, hydrophobic acrylic250Restrospective study2.9 years13.60%<0.00112%<0.001
AR40e (AMO)3-piece, sharp-edge, acrylic hydrophobic25426.80%25.20%
XL-Stabi (Zeiss)1-piece, sharp-edge, acrylic hydrophilic26352.90%51%
Ronbeck et al. [43]809C (Pharmacia)Round-edge, PMMA54Prospective randomized study5 years100% 54%<0.05
SI-40NB (AMO)Round-edge, silicone4812% 29%
Acrysof MA60BM (Alcon)Sharp-edge, acrylic hydrophobic5018% 8%
Vock et al. [46]Acrysof MA60BM (Alcon)3-piece, sharp-edge, hydrophobic acrylic98Retrospective study10 years91% grade 0
4% grade 1
4% grade 2
1% grade 3		0.00007342%0.007
SI-30NB/SI-40NB (AMO)3-piece, round optic edge, silicone4461% grade 0
30% grade 1
9% grade 2
0% grade 3		18%
Vock et al. [45]CeeOn 911A (AMO)3-piece, sharp-edge, silicone22Randomized and contralateral study6 years—0.00169%0.01
Acrysof MA60BM (Alcon)3-piece, sharp-edge, hydrophobic acrylic22—27.20%
Gauthier et al. [25]AcrySof ReSTOR (Alcon)Hydrophobic acrylic160Retrospective bilateral study2 years——8.80%0.0001
Acri.Lisa (Zeiss)Hydrophilic acrylic with hydrophobic surface152—37.20%
Iwase et al. [28]AcrySof SA60AT1-piece, sharp-edge, hydrophobic acrylic63Prospective randomized and contralateral study2 years—<0.0012%<0.01
Meridian HP60M (B&L)1-piece, double square-edge, hydrophilic acrylic63—13%
Vasavada et al. [34]Acrysof IQ SN60WF (Alcon) versus C-flex 570C (Rayner)Hydrophobic acrylic versus hydrophilic acrylic66Prospective randomized and contralateral study3 years—00% versus 12.9%0.04
Acrysof IQ SN60WF (Alcon) versus Akreos Adapt (B&L)Hydrophobic acrylic versus hydrophilic acrylic62—00% versus 16.1%0.02
Zemaitiene and Jasinskas [47]Acrysof MA30BA (Alcon)3-piece, hydrophobic acrylic31Prospective randomized study3 years—0.9959%NS
Acrysof SA30AL (Alcon)1-piece, hydrophobic acrylic31—3.10%
CeeOn 911A (AMO)3-piece, silicone30—0%
Chang et al. [24]Acrysof SA60AT (Alcon)1-piece, hydrophobic acrylic40Prospective randomized study5–7 years—0.553522%>0.05
Sensar AR40e (AMO)3-piece, hydrophobic acrylic40—10%
Leydolt et al. [14]iMics1 NY-60 (Hoya)1-piece, sharp-edge optimized, hydrophobic acrylic100Prospective, randomized and contralateral study3 years—<0.00135.60%0.001
Acrysof SN60WF (Alcon)1-piece, sharp-edge, hydrophobic acrylic100—13.70%
Morgan-Warren and Smith [32]Hoya FY60AD (HOYA)3-piece, round-edge, hydrophobic acrylic315Retrospective comparative study2 years——8.90%0.03
Hoya PY60AD (HOYA)3-piece, sharp-edge, hydrophobic acrylic254—4.30% 
Acrysof SN60WF (Alcon)1-piece, sharp hydrophobic acrylic696—1.40%0.007
Bourdiol Ducasse et al. [22]Acrysof SN60WF (Alcon)1-piece, square-edge, hydrophobic acrylic126Retrospective study2-3 years——10.30%
Akreos AO-MI60 (B&L)1-piece, square-edge, hydrophilic acrylic89—36%
Hoya YA-60BB (Hoya)3-piece, square-edge, hydrophobic acrylic85—24.90%
Cullin et al. [37]AcrySof SN60 (Alcon)Hydrophobic acrylic375Retrospective study41.5 months——7.50%<0.001
Akreos Adapt (B&L)Hydrophilic acrylic350—17.70%
Tecnis Acryl Z9003 (AMO)Hydrophobic acrylic801—3.70%
Fong et al. [38]
AcrySof SA60AT (Alcon)1-piece, square-edge, hydrophobic acrylic1016Prospective cohort study
3 years
34.40%—
——
MA50BM (Alcon)3-piece, square-edge, hydrophobic acrylic6750.80%—
Sensar AR40e (AMO)3-piece, round-edge, hydrophobic acrylic15638.50%—
Akreos Adapt (B&L)/Quatrix (Croma)Square-edge, hydrophilic acrylic10164.40%—
Ronbeck and Kugelberg [12]809C (Pharmacia)Round-edge, HSM PMMA61Prospective randomized study12 years——57.40%
SI-40NB (AMO)round-edge, silicone59—28.80%
Acrysof MA60BM (Alcon)Sharp-edge, hydrophobic acrylic59—32.20%