Washout Duration of Prostaglandin Analogues: A Systematic Review and Meta-analysis

Table 2

Pre-and postwashout IOP of prostaglandin analogues in research studies 1997–2012, n = 8 studies.

References	Study design	Study location	Medication	N	Treatment (weeks)	Washout (weeks)	IOP
							Baseline		Afterwashout		value
							Mean	SD	Mean	SD
Aung et al. [18]	RCT	Singapore	Latanoprost	27	4	3	22.8	2.08	22.2	3.12	0.4095
			Unoprostone	29	4	3	24.3	3.23	20.9	2.70	<0.001
Kobayashi et al. [19]	RCT	Japan	Latanoprost	20	13.3 ± 5.6	4	23.6	1.6	19.5	1.2	<0.001
Larsson [20]	RCT	Sweden	Latanoprost	27	4	4	23.6	1.04	23.8	1.04	0.4830
Linden et al. [21]	Prospective case series	Sweden	Latanoprost	26	26–52	2	—	—	—	—	—
Sehi et al. [22]	RCT	US	Latanoprost	68	—	4	18.8	4.7	18.0	4.3	0.3023
Sit et al. [23]	Prospective open label	US	Travoprost	20	—	41–63 (hrs)	21.5	2.9	19.6	2.6	0.0354
Stewart et al. [22, 23]	Prospective open label	US	Latanoprost	17	—	4	—	—	—	—	—
Walters et al. [24]	RCT	US	Latanoprost	36	—	4	23.6	2.1	23.6	0.3	1
			Bimatoprost	37	—	4	24.1	2.6	24.1	0.1	1

RCT: randomized control trial; value: Student’s t test comparing pre- and postwashout IOP.