Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer

Table 2

Clinical classification of neurotrophic keratopathy based on the Mackie classification.

Stage	Clinical findings
I	Corneal epithelial irregularity
	Gaule spots
	Superficial punctuate keratopathy
	Increase viscosity of tear mucus
	Decrease break-up time
	Superficial corneal neovascularization
	Stromal scarring
	Dellen
II	Persistent corneal epithelial defect with smooth and rolled epithelium edges
	Descemet’s membrane folds
	Stroma swelling
	Anterior chamber inflammatory reaction (±hypopyon)
III	Corneal ulcer
	Stromal melting
	Corneal perforation