Research Article
Clinical and Genetic Features of Tubulointerstitial Nephritis and Uveitis Syndrome with Long-Term Follow-Up
| | Case | Type | Steroid | Secondary glaucoma | Recurrence | Last follow-up data | Follow-up (months) | HLA | | Topical | Subconjunctival | Systemic (initial dose)
[dose after recurrence] | Blood test Cr (mg/dl) | Urinalysis β2-MG (μg/L) | HLA-A | HLA-B | HLA-C | HLA-DQ | HLA-DR |
| | 1 | Definite | + | − | +
(15 mg) | − | − | 0.69 | n.d. | 23 | A24:02
A26:01 : 01 | B40:02 : 01
B48:01 : 01 | C03:04 : 01
C08:03 : 01 | DQA103 : 01 : 01
DQA103 : 03
DQB103 : 02 : 01 DQB104 : 01 : 01 | DRB104 : 05
DRB108 : 02
DPB102 : 02
DPB105 : 01 | | 2 | Probable | + | + | − | − | − | 0.49 | 54 | 47 | A31 | B60/B55 | − | − | DRB104
DRB114 | | 3 | Definite | + | − | +
(30 mg)
[80 mg]
[80 mg] | − | 3 and 6 months | 0.50 | 125 | 86 | A2/A31 | B7/B40 | − | DQA101
DQA103
DQB105
DQB104 | DRB101
DRB104 | | 4 | Probable | + | + | +
(60 mg)
[20 mg] | + | 3 months | 0.70 | 94 | 69 | A11 | B54(22)/B35 | Cw1/Cw3 | − | DR4 | | 5 | Probable | + | − | − | − | − | 0.70 | 102 | 46 | A24/A26 | B7/B56 | C0401
C0702 | − | DRB101
DRB104 |
|
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n.d.: not done; β2-MG: β2 microglobulin.
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