Inhibition of Proteasome Activity Upregulates IL-6 Expression in RPE Cells through the Activation of P38 MAPKs

Figure 1

Proteasome inhibition upregulated IL-6 mRNA production in RPE. ARPE-19 cells were cultured in the presence of MG132 for 1, 4, and 8 h. Levels of mRNA for IL-6 were assessed by real-time RT-PCR analysis. GAPDH mRNA was used as a control to normalize the total mRNA levels. The results are the mean ± SD of two independent experiments.