Efficacy of Osthole in Management of Hypoperfused Retina

Figure 2

Retina histopathology and morphology results. Retina histopathology and morphology of each group after sacrifice. Scale bar: 50 μm. Retinal thickness in each group at days 5, 10, and 15 after drug administration (a). Bars indicate average thickness ± SEM (). ; . Osthole-IG group retina were thicker than in the other groups at day 15. Osthole-PI group retinal thickness was comparable to the control group retinal thickness at day 5, though the effect was not sustained at day 15. The number of ganglion cells (RGCs) (b) and the thickness of the inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL), and outer nuclear (ONL) layers also present with the same results (c).

(a)

(b)

(c)