Assessment of Global and Local Alterations in Retinal Layer Thickness in Ins2 (Akita) Diabetic Mice by Spectral Domain Optical Coherence Tomography

Figure 1

Examples of SD-OCT images acquired in wild-type (a and b) and Akita (c and d) mice. Individual retinal layers are labeled: nerve fiber layer (NFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), external limiting membrane (ELM), inner segments (IS), inner segment ellipsoid (ISe), outer segments (OS), retinal pigment epithelium (RPE), and choroid. Segmentation lines outlining 4 retinal cell layer interfaces are displayed, corresponding to the vitreous/internal limiting membrane (ILM); INL/OPL; ONL/ISe; and OS/RPE. Inner retinal thickness (IRT), outer retinal thickness (ORT), total retinal thickness (TRT), and photoreceptor outer segment length (OSL) are indicated by vertical arrows.

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