High Concentration of Glucose Increases Reactive Oxygen Species Generation and Apoptosis Induced by Endoplasmic Reticulum Stress Pathway in Rabbit Corneal Epithelial Cells

Figure 4

The expressions of ER stress-related molecules in RECEs. The expressions of Akt, p-Akt, PERK, p-PERK, CHOP, and β-actin were detected by western blot assay (a). The expressions of p-PERK and CHOP in the HCG group increased significantly than those in the OPC group and the NCG group, while p-Akt expression decreased significantly ( versus OPC and versus NCG). The expressions of p-PERK and CHOP in the HCG + NAC group decreased significantly than that in the HCG group, while p-Akt expression increased significantly ( versus HCG). Statistical analysis (b) was represented as mean ± SD ( and ).

(a)

(b)