Comparison of SNP Genotypes Related to Proliferative Vitreoretinopathy (PVR) across Slovenian and European Subpopulations
Table 2
Genotype distributions of 4 SNPs in Slovenian patients with PVR and 96 healthy controls. Inheritance models and odds ratios (ORs) were determined.
Gene
SNP
Genotype
Genotype frequency in healthy controls (%)
Genotype frequency in cases (%)
Inheritance model
OR (95% CI)
value
IL1A
rs17561
CC
49 (51)
49 (43.39)
Codominant (CC-CA/AA)
3.00 (0.77–11.75)
0.036
C/A
CA
38 (40)
59 (52.29)
AA
9 (9)
3 (2.7)
ND
0 (0)
2 (1.8)
Total number of participants
96 (100)
113 (100)
IL2
rs2069763
CC
39 (41)
52 (46.0)
Recessive (CC/CA-AA)
1.51 (0.71–3.18)
0.28
C/A
CA
39 (41)
46 (40.7)
AA
18 (19)
15 (13.3)
Total number of participants
96 (100)
113 (100)
LTA
rs2229094
CC
8 (8.3)
15 (9.8)
Additive
1.15 (0.78–1.70)
0.49
T/C
TC
33 (34.4)
55 (36.0)
TT
55 (57.3)
79 (51.6)
ND
0 (0)
4 (2.6)
Total number of participants
96 (100)
153 (100)
TNF
rs1800629
GG
74 (77)
96 (62.7)
Overdominant (GG-AA/AG)
0.48
0.014
G/A
AG
20 (21)
54 (35.3)
0.27–0.87
AA
2 (2)
3 (2.0)
Total number of participants
96 (100)
153 (100)
Abbreviations: OR: odds ratio; 95% CI: 95% confidence interval; ND: patients, in which genotype could not be identified. Inheritance models: additive: each copy of the rare variant modifies the risk; dominant: a single copy of the frequent variant is enough to modify the risk; recessive: two copies of the variant allele are necessary to change the risk; overdominant: heterozygosity modifies the risk. In case of IL2, the inheritance model could be also additive (OR, 1.23; 95% CI, 0.84–1.80; ).
