Association of Genes in the High-Density Lipoprotein Metabolic Pathway with Polypoidal Choroidal Vasculopathy in Asian Population: A Systematic Review and Meta-Analysis

Yuan, Ming-zhen; Han, Ruo-an; Zhang, Chen-xi; Chen, You-xin

doi:https://doi.org/10.1155/2018/9538671

Journal of Ophthalmology

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Genetics in Ophthalmology

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Review Article | Open Access

Volume 2018 | Article ID 9538671 | https://doi.org/10.1155/2018/9538671

Association of Genes in the High-Density Lipoprotein Metabolic Pathway with Polypoidal Choroidal Vasculopathy in Asian Population: A Systematic Review and Meta-Analysis

Ming-zhen Yuan,¹Ruo-an Han,¹Chen-xi Zhang,¹and You-xin Chen¹

Academic Editor: Lev Prasov

Received18 Nov 2017

Accepted29 Mar 2018

Published06 Jun 2018

Abstract

Purpose. To assess the association of genes in the high-density lipoprotein metabolic pathway (HDLMP) with polypoidal choroidal vasculopathy (PCV) and the genetic difference in the HDLMP between PCV and age-related macular degeneration (AMD). Methods. We performed a literature search in EMBASE, PubMed, and Web of Science for genetic studies on 7 single nucleotide polymorphisms (SNPs) from 5 genes in the HDLMP including cholesteryl ester transfer protein (CETP), hepatic lipase (LIPC), lipoprotein lipase (LPL), ATP-binding cassette transporter A1 (ABCA1), and ATP-binding cassette transporter G1 (ABCG1) in PCV. All studies were published before September 30, 2017, without language restriction. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) of each polymorphism were estimated. We also compared the association profiles between PCV and AMD and performed a sensitivity analysis. Results. Our result is based on 43 articles. After excluding duplicates and articles without complete information, 7 studies were applicable to meta-analysis. 7 polymorphisms were meta-analyzed: CETP rs2303790/rs3764261, LIPC rs10468017/rs493258, LPL rs12678919, ABCA1 rs1883025, and ABCG1 rs57137919. We found that in Asian population, CETP rs3764261 (T allele; OR = 1.46; 95% CI: 1.28–1.665, ), CETP rs2303790 (G allele; OR = 1.57; 95% CI: 1.258–1.96, ), and ABCG1 rs57137919 (A allele; OR = 1.168; 95% CI: 1.016–1.343, ) were significantly associated with PCV, and ABCG1 rs57137919 (A allele; OR = 1.208, 95% CI: 1.035–1.411, ) has different effects in PCV and AMD. The other 4 polymorphisms in LIPC/LPL/ABCA1 had no significant association with PCV (). The sensitivity analysis validated the significance of our analysis. Conclusions. Our study revealed 7 polymorphisms in 5 genes. Among them, CETP (rs3764261/rs2303790) and ABCG1 (rs57137919) were the major susceptibility genes for PCV in Asian population and ABCG1 (rs57137919) showed allelic diversity between PCV and AMD. Since the size for PCV and AMD was small, we need to study these genes genotyping in larger samples.

1. Introduction

Polypoidal choroidal vasculopathy (PCV) is a choroidal vascular disease of first described in the early 1980s as polypoidal subretinal vascular lesions associated with serous or hemorrhagic detachment of the retinal pigment epithelium (RPE) [1]. Later, PCV is regarded as a particular type of choroidal neovascularization (CNV) characterized by the distinct presence of polypoidal vascular lesions and a branching vascular network. PCV can be clearly demonstrated and diagnosed by indocyanine green angiography [2]. From a clinical perspective, PVC is considered as a subtype of AMD because of some similarities like neovascularization, subretinal hemorrhage and fluid, pigment epithelial detachment (PED), vision loss owing to bleeding, leakage, scar formation, and other similarities in phenotypic features [3–6]. Genetically, PCV and AMD also have the common susceptible genes, such as high temperature required factor A1 gene (HTRA1) and the complementary factor H gene (CFH) [7]. However, many controversial studies demonstrate that PCV should be classified as a distinct disease entity of AMD for their different epidemiological, clinical characteristics, natural history, and treatment outcomes [8–11]. Moreover, recent researches in the field of genetics suggest that PCV may not be as closely related to AMD, such as its differential risk to a mutation in FGD6, viralicidic activity 2-like (SKIV2L), complement component 3 (C3), elastin (ELN), and apolipoprotein E (APOE) [12–16]. These literatures make for a question whether PCV is a subtype of AMD or a distant disease from AMD.

Many studies have indicated lipid deposition in Bruch’s membrane and soft drusen, and the amount of lipid was lower in the peripheral area than in the macula of human eyes [17]. A number of population-based studies revealed the association between drusen and the AMD, and drusen are regarded as one of the determinant factors of both early and late AMD [18, 19]. In addition, some studies indicated that the prevalence of drusen under RPE was lower in PCV than in AMD [20, 21], which pointed out that absence of drusen may be one of the important criteria to diagnose PCV. However, some clinical studies insisted that drusen were frequently seen in PCV [22, 23], and several studies reported that drusen were observed in 20% to 27% of unaffected [21, 24]. Therefore, whether drusen plays a functional role in the occurrence and development is still up for debate. As we know, lipids stand for over 40% of the drusen volume [25]; therefore, many academics studied the vital function of lipids in the pathogenesis of PCV and AMD. Due to the different ethnic groups and lifestyles of individuals, the strength of such relevances is widely variable [26–28]; therefore, many studies investigated the effect between gene variations in the HDLMP and risk factors on PCV and AMD. Genetic studies in the HDLMP with PCV and AMD have identified susceptibility single nucleotide polymorphisms (SNPs) in multiple genes, including rs3764261/rs2303790 in CETP, rs493258/rs10468017 in LIPC, rs12678919 in LPL, rs1883025 in ABCA1, and rs57137919 in ABCG1.

Thus far, some studies have studied the impact of lipid metabolism-related and systemic lipoprotein genes in PCV. Here, in order to give the comprehensive analysis of effects and solve the controversies, we conduct meta-analysis and report a systematic review by summing up all published articles of genetic associations in the HDLMP of PCV. This study (1) conducted an investigation of which genetic variants of the HDLMP are meaningfully associated with PCV and their effect sizes and (2) analyzed whether there were differences between genetic risks of the HDLMP in PCV and AMD.

2. Methods

2.1. Search Strategy

We searched EMBASE, PubMed, and Web of Science using the following MeSH terms and free words: (polypoidal choroidal vasculopathy or polypoidal choroidal vascular disease or polypoidal choroidal vascular diseases or PCV) and (cholesteryl ester transfer protein or CETP or hepatic lipase or LIPC or lipoprotein lipase or LPL or ATP-binding cassette transporter A1 or ABCA1 or ATP-binding cassette transporter G1 or ABCG1). All searched articles were published before September 30, 2017, without language restriction. We also screened the reference lists of all eligible studies, reviews, and meta-analyses to ensure that any relevant studies were not omitted. We also searched all reported genome-wide association studies of PCV including the supplementary materials to maximize the usable data. The detail of search strategy is revealed in Table S1.

2.2. Inclusion and Exclusion Criteria

We included those studies that satisfied the following criteria in the meta-analysis: (1) case-control studies, cohort studies, or population-based studies that evaluated the association of gene variants of CETP/LIPC/LPL/ABCA1/ABCG1 with PCV or its subtypes and (2) allele or genotype counts and/or frequencies being presented or able to be calculated from the data in the study. Case reports, conference reports, reviews, animal studies, and reports with insufficient information were excluded (Table S2).

2.3. Data Extraction and Quality Assessment

Two reviewers (Y. M. z. and Y. J. y.) independently reviewed and extracted data from studies on the association between CETP/LIPC/LPL/ABCA1/ABCG1 SNPs and PCV. If there were any differences between them, another two reviewers would help to resolve it (Z. C. x. and H. R. a.) after thorough discussion. The following information was extracted from each article: the name of first author, publication year, ethnicity of the study population, study design, genotyping method, sample size, demographics, allele and genotype distribution (Table 1), and the results of the Hardy–Weinberg equilibrium (HWE) test in controls (Table S3). We assessed the quality of individual studies using the Newcastle–Ottawa Scale [29]. Briefly, 9 quality indicators were used; if a study fulfilled 1 indicator, we assigned a “yes” under this item or a “no.” Thus, the quality score for each study might be between 0 and 9 (Table S4).

2.4. Statistical Analysis

We conducted meta-analysis for each polymorphism which had been reported in ≥2 studies or cohorts. The association was evaluated by different genetic models, including allelic, heterozygous, and homozygous models. For each study, the odds ratio (OR) with 95% confidence interval (95% CI) was calculated to evaluate the strength of association between the each SNP and PCV risk. Moreover, we used the I² value to quantify the proportion of the variability in effect estimates, which is due to heterogeneity rather than sampling error. The I² value was shown as of no (0–25%), low (25–50%), moderate (50–75%), or high heterogeneity (75–100%) [30]. The I² test was to assess heterogeneity among studies. The potential publication bias was assessed visually in a funnel plot of log (OR) against its standard error, and the degree of asymmetry was evaluated using Begg’s test and Egger’s test ( was considered to be statistically significant). We undertook the sensitivity analysis to examine the influence by removing the unreliable study [31]. The software STATA (version 12.0, StataCorp LP, College Station, TX) was used for the meta-regression analysis. A pooled value of less than 0.05 was considered statistically significant.

3. Results

3.1. Eligibility and Characteristics of Included Studies

Figure 1 illustrates the study inclusion of this meta-analysis. A total of 43 articles published before September 30, 2017, were identified in the EMBASE, PubMed, and Web of Science databases. Of these, we excluded 20 articles because they were duplicates. For the remaining 23 studies, the full texts were retrieved. After reviewing the full texts, we excluded another 16 reports, among which 5 studies were reviews, 4 were not related to PCV, 4 were conference abstracts, 1 was not about the genetic studies, 1 did not separate PCV from AMD, and 1 was not the case-control study. Finally, 7 articles were eligible for the meta-analysis [32–38], involving 3342 PCV cases versus 8256 controls and 2761 PCV cases versus 2660 AMD cases. The main traits of the included studies are summed up in Table 1. Patients from each study received complete ophthalmic examinations, including fluorescein angiography and ICGA. Polypoidal choroidal vasculopathy was diagnosed on the basis of choroidal polypoidal lesions shown by ICGA. All studies adopted a case-control design. These studies were performed in various populations, including Chinese (6 studies), Japanese (3 studies), and Korean (1 study). In all studies, valid genotyping approaches were used, including polymerase chain reaction, TaqMan genotyping assay, and BeadChip.

3.2. Risk of Bias Assessment in Eligible Studies

As shown in Table S4, all eligible studies clearly described the diagnostic criteria for PCV and AMD. Patients with other macular diseases like central serous chorioretinopathy, myopic choroidal neovascularization, angioid streaks, presumed ocular histoplasmosis, or with CNV and PCV in the same or fellow eye were excluded. In all studies, comprehensive ophthalmic examinations were performed on the control subjects. One study used control subjects recruited from the community [32], and the others used hospital-recruited controls. Two studies were diverse-ethnic population study [37, 38]. One study did not provide the sex and age of cohorts. There was no ethnic difference between cases and controls. Confounding factors were matched between cases and controls in 7 studies. The scores for the quality assessment ranged from 5 to 7. All the studies informed HWE in controls.

3.3. Meta-Analysis of CETP/LIPC/LPL/ABCA1/ABCG1 Polymorphisms in PCV

Totally 17 SNPs had been studied in PCV in the literature (Figure 2). However, only 7 SNPs (CETP rs2303790/rs3764261, LIPC rs10468017/rs493258, LPL rs12678919, ABCA1 rs1883025, and ABCG1 rs57137919) in PCV were reported in more than one study and thus eligible for meta-analysis (details can be seen in Table S5). Summary of the allelic associations of these polymorphisms is shown in Table 2. The other 10 SNPs reported in only one report but performed no association with PCV [33, 36].

(a)

(b)

(c)

(d)

(e)

(f)

(g)

CETP rs3764261 is the most widely investigated SNP in PCV, with a number of 1355 cases and 1493 controls studied for the meta-analysis [32, 33, 35, 36]. The results showed statistically significant association between CETP rs3764261 and PCV in Asian population (Table 2). As for the allelic model, the odds ratio (OR) for the risk allele T was 1.46 (95% confidence interval (CI): 1.28–1.665, , I² = 0%). In the subgroup analysis by ethnicity, still significant association was detected in Chinese (OR = 1.528, 95% CI: 1.268–1.841, , I² = 0%). Also, CETP rs2303790 [33, 38] and ABCG1 rs57137919 [35, 37] showed significant associations with PCV in the allelic model. As for CETP rs2303790, the frequency of the G allele was significantly higher in PCV patients than in controls, conferring a 1.57-fold increased risk toward PCV (95% CI: 1.258–1.96, , I² = 0). As for ABCG1 rs57137919, the frequency of the A allele was significantly higher in PCV patients than in controls, conferring a 1.168-fold increased risk (95% CI: 1.016–1.343, , I² = 61.5%). Through quality assessment and sensitivity analysis, we found the heterogeneity derived from the data of Shantou population [37]. After excluding the data of Shantou population, the result showed that the pooled allelic OR was significantly elevated (A allele; OR = 1.313, 95% CI: 1.113–1.548, , I² = 0%). Regarding the other 4 SNPs, LIPC rs10468017/rs493258, LPL rs12678919, and ABCA1 rs1883025, the pooled ORs were not statistically significant in PCV in the allelic (). As for ABCA1 rs1883025 (T allele; OR = 0.968, 95% CI: 0.828–1.131, , I² = 78.2%), quality assessment and sensitivity analysis showed that the study of Zhang et al. was of higher risk of causing bias than the other cohorts [33]. Therefore, we excluded the study and also found that the pooled allelic OR was not significant (T allele; OR = 1.1, 95% CI: 0.926–1.335, , I² = 0%).

3.4. Meta-Analysis of CETP/LIPC/LPL/ABCA1/ABCG1 Polymorphisms Compared between PCV and AMD

We identified 6 studies in which both PCV and AMD were assessed for associations with a total of 7 SNPs in 5 genes (i.e., CETP rs2303790/rs3764261, LIPC rs10468017/rs493258, LPL rs12678919, ABCA1 rs1883025, and ABCG1 rs57137919) (Table 3 and Figure 3). Only 1 SNP (ABCG1 rs57137919) showed significant difference between PCV and AMD (A allele; OR = 1.208, 95% CI: 1.035–1.411, , I² = 0%) [35, 37]. The other 6 SNPs, namely, CETP rs2303790/rs3764261, LIPC rs10468017/rs493258, LPL rs12678919, and ABCA1 rs1883025, were evaluated in 2 to 3 cohorts and showed no significant differences between PCV and AMD (). As for CETP rs3764261 (T allele; OR = 1.17, 95% CI: 0.971–1.409, , I² = 33.6%), quality assessment and sensitivity analysis showed that the study of Liu et al. was of higher risk of causing bias than the other cohorts [35]. Therefore, we ruled out the cohort, and then the pooled allelic OR of the result was significant (T allele; OR = 1.301, 95% CI: 1.033–1.638, , I² = 0%) [33, 36].

(a)

(b)

(c)

(d)

(e)

(f)

(g)

3.5. Publication Bias Analysis

In theory, due to the limited number of available studies, it is not suitable for publication bias analysis. But in order to make this meta-analysis more powerful and more creditable, we used funnel plots and Begg’s/Egger’s test to detect publication bias. Begg’s test and Egger’s test suggested an absence of publication bias in the all SNPs () (Tables 2 and 3). The shape of the funnel plots did not reveal any evidence of obvious asymmetry (Figures S1 and S2).

4. Discussion

In the systematic review and meta-analysis, we have summarized the association profiles of genes in the HDLMP in PCV and assessed the genetic difference in the HDLMP between PCV and AMD for the first time (i.e., CETP, LIPC, LPL, ABCA1, and ABCG1). We found significant association between reported CETP rs2303790/rs3764261, ABCG1 rs57137919, and PCV. Also, we identified ABCG1 rs57137919 showing significant differences between PCV and AMD. In contrast, LIPC rs10468017/rs493258, LPL rs12678919, and ABCA1 rs1883025 were not statistically significant in PCV and reported SNPs in 4 genes in the HDLMP (i.e., CETP, LIPC, LPL, and ABCA1) showed no significant differences between PCV and AMD.

CETP can make oxidized lipids transfer from the outer segments of the photoreceptors or other membranes to HDL-like lipoprotein particles. The particles are internalized by RPE and excreted back into the circulation via ABCG1 transporters through Bruch’s membrane [39]. ABCG1 was relevant to an increased macrophage apoptosis, which may be due to the accumulation of oxysterol in macrophages caused by decreased ABCG1-mediated cholesterol efflux [40]. ABCA1 was expressed in the retina and retinal pigment epithelium [41], and ABCA1 can form nascent HDL by mediating the efflux of cholesterol and phospholipids to lipid-poor apolipoproteins [42, 43]. Also, several studies have demonstrated ABCA1 was significantly related to the progression of drusen, but the association between large drusen and geographic atrophy/neovascular was not significant [44]. Besides, LIPC gene is a critical enzyme in HDL metabolism which has the function of encoding hepatic triglyceride lipase and catalyzing the hydrolysis of phospholipids, monoglycerides, diglycerides, triglycerides, and acylCoA thioesters [45, 46]. LPL gene encodes LPL which can play an important role in HDL metabolism. LPL can not only facilitate triglyceride hydrolysis but also serve as a ligand/bridging factor for receptor-mediated lipoprotein uptake [47]. Besides, lipoproteins derived from plasma have been proved to be the crucial upstream source of fatty acids within Bruch’s membrane and supply an energy source to the retina [48–50] as well as perform significant roles in the transportation of vitamin C, vitamin E, lutein, and zeaxanthin for use by photoreceptors [51, 52]. Therefore, dysfunction of CETP, LIPC, LPL, ABCA1, and ABCG1 may cause accumulation of oxidized lipids in the retina, and the unreasonable products could induce inflammation and vascular anomaly, which play a crucial role in the development of PCV and AMD via lipid metabolism [53, 54].

In the studies (including 3 in Chinese [33, 35, 36] and 1 in Japanese [32]), we found that CETP rs3764261 was to be associated with PCV in Asian population with an odds ratio of 1.46 (95% CI: 1.28–1.665, , I² = 0%) for the T allele. Apart from CETP rs3764261, we also found that CETP rs2303790 was associated with PCV in Asian population [33, 38] (G allele; OR = 1.57, 95% CI: 1.258–1.96, , I² = 0). Therefore, CETP rs3764261/rs2303790 provided an increased risk for PCV in Asian population. Through the analysis of the studies in which both PCV and AMD were assessed for associations with CETP, we found CETP rs2303790 showed no significant difference between PCV and AMD. However, as for CETP rs3764261, two studies dedicated that CETP rs3764261 was significantly associated with an increased risk for PCV, but no association was found with AMD(T allele; OR = 1.301, 95% CI: 1.033–1.638, , I² = 0%) [33, 40], but one study showed that CETP rs3764261 is a susceptibility gene for PCV and AMD [35]. According to the article of GWAS and meta-analysis published by Cheng et al., the minor allele at CETP rs3764261 variant was proved to be a risk factor to the development of AMD in Asian population [55]. However, several recent studies indicated that CETP rs3764261 was related to a decreased risk of AMD in Chinese population and Lithuanian population [56, 57]. Therefore, it is still disputed whether CETP rs3764261 has different effects in PCV and AMD, and we need further studies in which both PCV and AMD are assessed for associations with CETP to confirm it.

From the studies [35, 37], for ABCG1 rs57137919, the frequency of the A allele in PCV patients was significantly higher than in controls (OR = 1.168, 95% CI: 1.016–1.343, , I² = 61.5%). Interestingly, we found the result had the heterogeneity. Through quality assessment and sensitivity analysis, we found the heterogeneity derived from the data of Shantou population. After reading the related articles, we found all the studies used TaqMan genotyping assays, as well as the same inclusion criteria and exclusion criteria. Therefore, we speculate that there may be racial differences between Shantou population and others, but we need further studies to prove the view and find the causes of heterogeneity. Also, we found the significant difference between PCV and AMD in ABCG1 rs57137919 (G allele; OR = 1.208, 95% CI: 1.035–1.411, , I² = 0%). In one of the studies, Li et al. studied the relevance of ABCG1 rs57137919 to PCV and AMD in Hong Kong, Shantou, and Osaka study subjects, and the results showed that the association of ABCG1 rs57137919 with PCV was significant in the Hong Kong cohort, but not in the Shantou or the Osaka cohort. Also, they indicated that the association of ABCG1 rs57137919 with AMD was not significant in the Hong Kong, Shantou, and Osaka cohorts. In another study, Liu et al. provided putative evidence of a role of ABCG1 rs57137919 in the vascularized complication of PCV. Because there were only two studies about relevance of ABCG1 rs57137919 to PCV and AMD, we need further replication studies in other ethnic populations to confirm the role of ABCG1 in PCV and AMD.

From our meta-analysis, we found other 4 SNPs (LIPC rs10468017/rs493258, LPL rs12678919, and ABCA1 rs1883025) were not statistically significant in PCV and AMD. Besides, the associations of eleven SNPs in CETP/LIPC/ABCA1/ABCG1 were reported in only 1 study [33, 36–38] (details can be seen in Table S5). Among these SNPs, Zhang et al. discovered that the rs5882 variant in CETP was significantly associated with PCV (G allele; ), but not with AMD (G allele; ), and suggested the need to find biological clues about the different underlying HDL pathways by separating PCV from AMD so as to explore the pathogenesis of PCV and AMD [33].

Another recent study reported that LIPC rs1532085 conferred an increased risk for PCV (A allele; ), but not AMD (A allele; ). Also, this study found hyperlipidemia is a risk factor for PCV [36]. Recently, Li et al. have newly identified ABCG1 rs225396 to be associated with PCV (T allele; ) and AMD (T allele; ) in Chinese and Japanese subjects, which pointed out ABCG1 as a new susceptibility gene for PCV and AMD [37]. In 2017, Qiao et al. reported that the strongest PCV-associated SNP, CETP rs183130 (T allele; ), was in high LD with the currently studied SNP rs3764261 in Europeans, and similar association patterns were shown in AMD at CETP rs183130 (T allele; ). Also, they found that the most significant association signals recognized in Europeans were at rs5817082, rs1864163, and rs17231506 in CETP, but only rs17232506 showed significant association with PCV and AMD [38]. However, all the results above were reported in only 1 study, and they were challenged by pretty small sample sizes, so we need more researches with independent cohorts to verify these association findings.

In conclusion, our systematic review and meta-analysis has provided an overview of the association profiles of genes in the HDLMP in PCV for the first time and assessed the genetic difference in the HDLMP between PCV and AMD. The results suggest that CETP (rs3764261/rs2303790) and ABCG1 (rs57137919) are the major susceptibility genes for PCV in the Asian population, and ABCG1 (rs57137919) has different effects in PCV and AMD in the Asian population. However, due to the small pooled sample size for PCV and AMD, further studies of these genes in larger samples are warranted to confirm the association of gene variations in the HDLMP with PCV in other populations such as Caucasian and Australian. Moreover, further studies should focus on the genotype-phenotype correlations and the relevance of genotype to therapy in PCV, which may provide us the clues about the pathogenesis of PCV.

Conflicts of Interest

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Supplementary Materials

Table S1: the search strategy applied in all databases. Table S2: lists of included/excluded studies with reasons. Table S3: Hardy–Weinberg equilibrium of polymorphisms in control subjects. Table S4: quality assessment of each study based on the Newcastle–Ottawa Scale. Table S5: the number of studies for CETP/LIPC/LPL/ABCA1/ABCG1 polymorphisms in PCV. Figure S1: funnel plot of 7 SNPs in PCV in the allelic model. Figure S2: funnel plot of 7 SNPs compared between PCV and AMD in the allelic model. (Supplementary Materials)

References

L. A. Yannuzzi, J. Sorenson, R. F. Spaide et al., “Idiopathic polypoidal choroidal vasculopathy (IPCV),” Retina, vol. 10, no. 1, pp. 1–8, 1990.
View at: Publisher Site | Google Scholar
C. S. Tan, W. K. Ngo, L. W. Lim et al., “A novel classification of the vascular patterns of polypoidal choroidal vasculopathy and its relation to clinical outcomes,” British Journal of Ophthalmology, vol. 98, no. 11, pp. 1528–1533, 2014.
View at: Publisher Site | Google Scholar
S. Honda, W. Matsumiya, and A. Negi, “Polypoidal choroidal vasculopathy: clinical features and genetic predisposition,” Ophthalmologica, vol. 231, no. 2, pp. 59–74, 2014.
View at: Publisher Site | Google Scholar
A. Laude, P. D. Cackett, E. N. Vithana et al., “Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: same or different disease?” Progress in Retinal and Eye Research, vol. 29, no. 1, pp. 19–29, 2010.
View at: Publisher Site | Google Scholar
L. A. Yannuzzi, D. W. Wong, B. S. Sforzolini et al., “Polypoidal choroidal vasculopathy and neovascularized age-related macular degeneration,” Archives of Ophthalmology, vol. 117, no. 11, pp. 1503–1510, 1999.
View at: Publisher Site | Google Scholar
J. Z. Kuo, T. Y. Wong, and F. S. Ong, “Genetic risk, ethnic variations and pharmacogenetic biomarkers in age-related macular degeneration and polypoidal choroidal vasculopathy,” Expert Review of Ophthalmology, vol. 8, no. 2, pp. 127–140, 2013.
View at: Publisher Site | Google Scholar
X. Y. Liang, T. Y. Lai, D. T. Liu et al., “Differentiation of exudative age-related macular degeneration and polypoidal choroidal vasculopathy in the ARMS2/HTRA1 locus,” Investigative Opthalmology and Visual Science, vol. 53, no. 6, pp. 3175–3182, 2012.
View at: Publisher Site | Google Scholar
D. R. Goldman, K. B. Freund, C. A. McCannel et al., “Peripheral polypoidal choroidal vasculopathy as a cause of peripheral exudative hemorrhagic chorioretinopathy: a report of 10 eyes,” Retina, vol. 33, no. 1, pp. 48–55, 2013.
View at: Publisher Site | Google Scholar
I. Mantel, A. Schalenbourg, and L. Zografos, “Peripheral exudative hemorrhagic chorioretinopathy: polypoidal choroidal vasculopathy and hemodynamic modifications,” American Journal of Ophthalmology, vol. 153, no. 5, pp. 910–922, 2012.
View at: Publisher Site | Google Scholar
S. Honda, H. Imai, K. Yamashiro et al., “Comparative assessment of photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: a multicenter study in Hyogo prefecture, Japan,” Ophthalmologica, vol. 223, no. 5, pp. 333–338, 2009.
View at: Publisher Site | Google Scholar
W. Matsumiya, S. Honda, S. Kusuhara et al., “Effectiveness of intravitreal ranibizumab in exudative age-related macular degeneration (AMD): comparison between typical neovascular AMD and polypoidal choroidal vasculopathy over a 1 year follow-up,” BMC Ophthalmology, vol. 13, no. 1, p. 10, 2013.
View at: Publisher Site | Google Scholar
L. Huang, H. Zhang, C. Y. Cheng et al., “A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy,” Nature Genetics, vol. 48, no. 6, pp. 640–647, 2016.
View at: Publisher Site | Google Scholar
K. Liu, T. Y. Lai, S. W. Chiang et al., “Gender specific association of a complement component 3 polymorphism with polypoidal choroidal vasculopathy,” Scientific Reports, vol. 4, no. 1, p. 7018, 2014.
View at: Publisher Site | Google Scholar
K. Liu, L. J. Chen, P. O. Tam et al., “Associations of the C2-CFB-RDBP-SKIV2L locus with age-related macular degeneration and polypoidal choroidal vasculopathy,” Ophthalmology, vol. 120, no. 4, pp. 837–843, 2013.
View at: Publisher Site | Google Scholar
N. Gotoh, S. Kuroiwa, T. Kikuchi et al., “Apolipoprotein E polymorphisms in Japanese patients with polypoidal choroidal vasculopathy and exudative age-related macular degeneration,” American Journal of Ophthalmology, vol. 138, no. 4, pp. 567–573, 2004.
View at: Publisher Site | Google Scholar
N. Kondo, S. Honda, K. Ishibashi et al., “Elastin gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy,” Investigative Opthalmology and Visual Science, vol. 49, no. 3, pp. 1101–1105, 2008.
View at: Publisher Site | Google Scholar
F. G. Holz, G. Sheraidah, D. Pauleikhoff et al., “Analysis of lipid deposits extracted from human macular and peripheral Bruch’s membrane,” Archives of Ophthalmology, vol. 112, no. 3, pp. 402–406, 1994.
View at: Publisher Site | Google Scholar
R. Reynolds, B. Rosner, and J. M. Seddon, “Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration,” Ophthalmology, vol. 117, no. 10, pp. 1989–1995, 2010.
View at: Publisher Site | Google Scholar
L. Hyman, A. P. Schachat, Q. He et al., “Hypertension, cardiovascular disease, and age-related macular degeneration. Age-related macular degeneration risk factors study group,” Archives of Ophthalmology, vol. 118, no. 3, pp. 351–358, 2000.
View at: Publisher Site | Google Scholar
Y. Hirami, M. Mandai, M. Takahashi et al., “Association of clinical characteristics with disease subtypes, initial visual acuity, and visual prognosis in neovascular age-related macular degeneration,” Japanese Journal of Ophthalmology, vol. 53, no. 4, pp. 396–407, 2009.
View at: Publisher Site | Google Scholar
I. Maruko, T. Iida, M. Saito et al., “Clinical characteristics of exudative age-related macular degeneration in Japanese patients,” American Journal of Ophthalmology, vol. 144, no. 1, pp. 15–22, 2007.
View at: Publisher Site | Google Scholar
T. Mathis, L. Kodjikian, M. Mauget-Faysse et al., “Polypoidal choroidal vasculopathy occurring in the context of large colloid drusen,” Ophthalmic Surgery, Lasers and Imaging Retina, vol. 47, no. 12, pp. 1154–1156, 2016.
View at: Publisher Site | Google Scholar
D. Iwama, A. Tsujikawa, M. Sasahara et al., “Polypoidal choroidal vasculopathy with drusen,” Japanese Journal of Ophthalmology, vol. 52, no. 2, pp. 116–121, 2008.
View at: Publisher Site | Google Scholar
I. D. Ladas, A. A. Rouvas, M. M. Moschos et al., “Polypoidal choroidal vasculopathy and exudative age-related macular degeneration in Greek population,” Eye, vol. 18, no. 5, pp. 455–459, 2004.
View at: Publisher Site | Google Scholar
L. Wang, M. E. Clark, D. K. Crossman et al., “Abundant lipid and protein components of drusen,” PLoS One, vol. 5, no. 4, Article ID e10329, 2010.
View at: Publisher Site | Google Scholar
R. Klein, T. Peto, A. Bird et al., “The epidemiology of age-related macular degeneration,” American Journal of Ophthalmology, vol. 137, no. 3, pp. 486–495, 2004.
View at: Publisher Site | Google Scholar
U. Chakravarthy, T. Y. Wong, A. Fletcher et al., “Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis,” BMC Ophthalmology, vol. 10, no. 1, p. 31, 2010.
View at: Publisher Site | Google Scholar
B. J. Cho, J. W. Heo, T. W. Kim et al., “Prevalence and risk factors of age-related macular degeneration in Korea: the Korea National Health and Nutrition Examination Survey 2010-2011,” Investigative Opthalmology and Visual Science, vol. 55, no. 2, pp. 1101–1108, 2014.
View at: Publisher Site | Google Scholar
D. Yuan, D. Yuan, S. Yuan et al., “The age-related maculopathy susceptibility 2 polymorphism and polypoidal choroidal vasculopathy in Asian populations: a meta-analysis,” Ophthalmology, vol. 120, no. 10, pp. 2051–2057, 2013.
View at: Publisher Site | Google Scholar
J. P. Higgins, S. G. Thompson, J. J. Deeks et al., “Measuring inconsistency in meta-analyses,” BMJ, vol. 327, no. 7414, pp. 557–560, 2003.
View at: Publisher Site | Google Scholar
A. Thakkinstian, G. J. McKay, M. McEvoy et al., “Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: a HuGE review and meta-analysis,” American Journal of Epidemiology, vol. 173, no. 12, pp. 1365–1379, 2011.
View at: Publisher Site | Google Scholar
I. Nakata, K. Yamashiro, T. Kawaguchi et al., “Association between the cholesteryl ester transfer protein gene and polypoidal choroidal vasculopathy,” Investigative Opthalmology and Visual Science, vol. 54, no. 9, pp. 6068–6073, 2013.
View at: Publisher Site | Google Scholar
X. Zhang, M. Li, F. Wen et al., “Different impact of high-density lipoprotein-related genetic variants on polypoidal choroidal vasculopathy and neovascular age-related macular degeneration in a Chinese Han population,” Experimental Eye Research, vol. 108, pp. 16–22, 2013.
View at: Publisher Site | Google Scholar
F. Li, Y. Li, M. Li et al., “ABCA1 rs1883025 polymorphism shows no association with neovascular age-related macular degeneration or polypoidal choroidal vasculopathy in a Northern Chinese population,” Ophthalmic Research, vol. 51, no. 4, pp. 210–215, 2014.
View at: Publisher Site | Google Scholar
K. Liu, L. J. Chen, T. Y. Lai et al., “Genes in the high-density lipoprotein metabolic pathway in age-related macular degeneration and polypoidal choroidal vasculopathy,” Ophthalmology, vol. 121, no. 4, pp. 911–916, 2014.
View at: Publisher Site | Google Scholar
Q. Meng, L. Huang, Y. Sun et al., “Effect of high-density lipoprotein metabolic pathway gene variations and risk factors on neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in China,” PLoS One, vol. 10, no. 12, Article ID e143924, 2015.
View at: Publisher Site | Google Scholar
L. Ma, K. Liu, M. Tsujikawa et al., “Association of ABCG1 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in Chinese and Japanese,” Investigative Opthalmology and Visual Science, vol. 57, no. 13, pp. 5758–5763, 2016.
View at: Publisher Site | Google Scholar
Q. Fan, C. Cheung, L. J. Chen et al., “Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians,” Journal of Human Genetics, vol. 62, no. 12, pp. 1049–1055, 2017.
View at: Publisher Site | Google Scholar
I. R. Rodriguez and I. M. Larrayoz, “Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration,” Journal of Lipid Research, vol. 51, no. 10, pp. 2847–2862, 2010.
View at: Publisher Site | Google Scholar
F. Liu, W. Wang, Y. Xu et al., “ABCG1 rs57137919G>a polymorphism is functionally associated with varying gene expression and apoptosis of macrophages,” PLoS One, vol. 9, no. 6, Article ID e97044, 2014.
View at: Publisher Site | Google Scholar
K. G. Duncan, K. Hosseini, K. R. Bailey et al., “Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium,” British Journal of Ophthalmology, vol. 93, no. 8, pp. 1116–1120, 2009.
View at: Publisher Site | Google Scholar
G. Schmitz and T. Langmann, “Structure, function and regulation of the ABC1 gene product,” Current Opinion in Lipidology, vol. 12, no. 2, pp. 129–140, 2001.
View at: Publisher Site | Google Scholar
S. Yokoyama, “ABCA1 and biogenesis of HDL,” Journal of Atherosclerosis and Thrombosis, vol. 13, no. 1, pp. 1–15, 2006.
View at: Publisher Site | Google Scholar
Y. Yu, R. Reynolds, B. Rosner et al., “Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models,” Investigative Opthalmology and Visual Science, vol. 53, no. 3, pp. 1548–1556, 2012.
View at: Publisher Site | Google Scholar
B. M. Neale, J. Fagerness, R. Reynolds et al., “Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC),” Proceedings of the National Academy of Sciences, vol. 107, no. 16, pp. 7395–7400, 2010.
View at: Publisher Site | Google Scholar
J. Lee, J. Zeng, G. Hughes et al., “Association of LIPC and advanced age-related macular degeneration,” Eye, vol. 27, no. 2, pp. 265–270, 2013.
View at: Publisher Site | Google Scholar
W. Chen, D. Stambolian, A. O. Edwards et al., “Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration,” Proceedings of the National Academy of Sciences, vol. 107, no. 16, pp. 7401–7406, 2010.
View at: Google Scholar
I. A. Pikuleva and C. A. Curcio, “Cholesterol in the retina: the best is yet to come,” Progress in Retinal and Eye Research, vol. 41, pp. 64–89, 2014.
View at: Publisher Site | Google Scholar
L. Bretillon, G. Thuret, S. Gregoire et al., “Lipid and fatty acid profile of the retina, retinal pigment epithelium/choroid, and the lacrimal gland, and associations with adipose tissue fatty acids in human subjects,” Experimental Eye Research, vol. 87, no. 6, pp. 521–528, 2008.
View at: Publisher Site | Google Scholar
L. Wang, C. M. Li, M. Rudolf et al., “Lipoprotein particles of intraocular origin in human Bruch membrane: an unusual lipid profile,” Investigative Opthalmology and Visual Science, vol. 50, no. 2, pp. 870–877, 2009.
View at: Publisher Site | Google Scholar
E. Loane, J. M. Nolan, and S. Beatty, “The respective relationships between lipoprotein profile, macular pigment optical density, and serum concentrations of lutein and zeaxanthin,” Investigative Opthalmology and Visual Science, vol. 51, no. 11, pp. 5897–5905, 2010.
View at: Publisher Site | Google Scholar
C. A. Curcio, M. Johnson, J. D. Huang et al., “Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins,” Progress in Retinal and Eye Research, vol. 28, no. 6, pp. 393–422, 2009.
View at: Publisher Site | Google Scholar
J. G. Hollyfield, V. L. Bonilha, M. E. Rayborn et al., “Oxidative damage-induced inflammation initiates age-related macular degeneration,” Nature Medicine, vol. 14, no. 2, pp. 194–198, 2008.
View at: Publisher Site | Google Scholar
P. X. Shaw, L. Zhang, M. Zhang et al., “Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids,” Proceedings of the National Academy of Sciences, vol. 109, no. 34, pp. 13757–13762, 2012.
View at: Publisher Site | Google Scholar
C. Y. Cheng, K. Yamashiro, L. J. Chen et al., “New loci and coding variants confer risk for age-related macular degeneration in East Asians,” Nature Communications, vol. 6, p. 6063, 2015.
View at: Google Scholar
D. Wang, J. Zhou, X. Hou et al., “CETP gene may be associated with advanced age-related macular degeneration in the Chinese population,” Ophthalmic Genetics, vol. 36, no. 4, pp. 303–308, 2015.
View at: Publisher Site | Google Scholar
R. Liutkeviciene, A. Vilkeviciute, G. Streleckiene et al., “Associations of cholesteryl ester transfer protein (CETP) gene variants with predisposition to age-related macular degeneration,” Gene, vol. 636, pp. 30–35, 2017.
View at: Publisher Site | Google Scholar

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Copyright © 2018 Ming-zhen Yuan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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