Association of Genes in the High-Density Lipoprotein Metabolic Pathway with Polypoidal Choroidal Vasculopathy in Asian Population: A Systematic Review and Meta-Analysis
Table 2
Meta-analysis of CETP/LIPC/LPL/ABCA1/ABCG1 polymorphisms in PCV.
Region
Gene
Polymorphism
Ethnicity
Associated versus reference allele
Number of cohorts
Sample size (case/control)
OR (95% CI)
Z score
value
I2 (%)
value of Begg’s test
value of Egger’s test
16q21
CETP
rs3764261
Asia
T versus G
4
1355/1493
1.46 (1.28–1.665)
5.64
0
0
0.308
0.415
Chinese
T versus G
3
774/700
1.528 (1.268–1.841)
4.46
0
0
>0.999
0.071
9q31
ABCA1
rs1883025
Chinese
T versus C
3
781/775
0.968 (0.828–1.131)
0.41
0.679
78.2
>0.999
0.745
9q31
LIPC
rs493258
Asia
G versus A
3
1064/1272
1.041 (0.907–1.195)
0.57
0.565
0
>0.999
0.867
15q22
LIPC
rs10468017
Chinese
T versus C
3
774/700
0.849 (0.7–1.028)
1.68
0.094
0
>0.999
0.465
15q22
LPL
rs12678919
Asia
G versus A
3
1122/1218
0.972 (0.814–1.161)
0.32
0.751
0
>0.999
0.799
21q22
ABCG1
rs57137919
Asia
A versus G
4
860/1467
1.168 (1.016–1.343)
2.18
0.029
61.5
>0.999
0.808
16q21
CETP
rs2303790
Asia
G versus A
5
1312/5479
1.57 (1.258–1.96)
3.99
0
0
>0.999
0.527
Summary of the allelic associations of CETP/LIPC/LPL/ABCA1/ABCG1 polymorphisms in PCV. PCV: polypoidal choroidal vasculopathy; AMD: age-related macular degeneration; OR: odds ratio; CI: confidence intervals.
