Research Article

Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy

Table 3

Structural measurements obtained with Spectralis OCT in patients with type 2 diabetes mellitus (DM2) with glycated hemoglobin (HbA1C) ≤7% and >7%, respectively.

HbA1C ≤ 7HbA1C > 7
MeanSDMeanSD

Macular thickness
Central279.0314.53271.7123.060.142
Inner superior338.6614.24331.6414.730.066
Inner nasal342.0613.73332.8616.520.022
Inner inferior334.0313.83328.9615.630.188
Inner temporal325.7813.39320.6816.060.185
Outer superior294.6313.73288.7915.450.127
Outer nasal311.5612.84302.5014.550.013
Outer inferior281.3112.96277.0415.510.249
Outer temporal282.8113.66277.0714.050.115

pRNFL Glaucoma
Average98.199.1593.3614.530.124
Superior123.9116.59113.3421.030.034
Nasal75.4411.8969.1117.220.100
Inferior125.5814.87121.8822.800.454
Temporal67.4410.5269.118.850.512
Superotemporal134.0017.98129.9325.580.474
Inferotemporal136.8415.54133.1125.050.485
Superonasal113.8122.1196.7520.570.003
Inferonasal114.3122.63110.6425.360.556

pRNFL Axonal Analytics
Average99.699.2394.1814.670.083
Superior124.3915.78115.3621.290.065
Nasal77.1912.8570.9317.480.117
Inferior128.4716.06122.1123.830.225
Temporal68.4411.4168.3910.620.988
Superonasal113.5020.12100.7120.990.019
Inferonasal117.3824.35111.5425.380.367
Superotemporal135.2819.50130.0025.050.363
Inferotemporal139.5615.96132.6825.540.210
Papillomacular bundle52.258.4854.438.110.315
Nasal/temporal index1.160.281.050.300.147

Bold letters indicate . Asterisks mark significant values according to Bonferroni corrections for multiple comparisons. DM2, type 2 diabetes mellitus; pRNFL: peripapillary retinal nerve fiber layer; SD, standard deviation.