Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy
Table 3
Structural measurements obtained with Spectralis OCT in patients with type 2 diabetes mellitus (DM2) with glycated hemoglobin (HbA1C) ≤7% and >7%, respectively.
HbA1C ≤ 7
HbA1C > 7
Mean
SD
Mean
SD
Macular thickness
Central
279.03
14.53
271.71
23.06
0.142
Inner superior
338.66
14.24
331.64
14.73
0.066
Inner nasal
342.06
13.73
332.86
16.52
0.022
Inner inferior
334.03
13.83
328.96
15.63
0.188
Inner temporal
325.78
13.39
320.68
16.06
0.185
Outer superior
294.63
13.73
288.79
15.45
0.127
Outer nasal
311.56
12.84
302.50
14.55
0.013
Outer inferior
281.31
12.96
277.04
15.51
0.249
Outer temporal
282.81
13.66
277.07
14.05
0.115
pRNFL Glaucoma
Average
98.19
9.15
93.36
14.53
0.124
Superior
123.91
16.59
113.34
21.03
0.034
Nasal
75.44
11.89
69.11
17.22
0.100
Inferior
125.58
14.87
121.88
22.80
0.454
Temporal
67.44
10.52
69.11
8.85
0.512
Superotemporal
134.00
17.98
129.93
25.58
0.474
Inferotemporal
136.84
15.54
133.11
25.05
0.485
Superonasal
113.81
22.11
96.75
20.57
0.003
Inferonasal
114.31
22.63
110.64
25.36
0.556
pRNFL Axonal Analytics
Average
99.69
9.23
94.18
14.67
0.083
Superior
124.39
15.78
115.36
21.29
0.065
Nasal
77.19
12.85
70.93
17.48
0.117
Inferior
128.47
16.06
122.11
23.83
0.225
Temporal
68.44
11.41
68.39
10.62
0.988
Superonasal
113.50
20.12
100.71
20.99
0.019
Inferonasal
117.38
24.35
111.54
25.38
0.367
Superotemporal
135.28
19.50
130.00
25.05
0.363
Inferotemporal
139.56
15.96
132.68
25.54
0.210
Papillomacular bundle
52.25
8.48
54.43
8.11
0.315
Nasal/temporal index
1.16
0.28
1.05
0.30
0.147
Bold letters indicate . Asterisks mark significant values according to Bonferroni corrections for multiple comparisons. DM2, type 2 diabetes mellitus; pRNFL: peripapillary retinal nerve fiber layer; SD, standard deviation.