COL11A1 Polymorphisms Are Associated with Primary Angle-Closure Glaucoma Severity

Table 5

SNP allele frequencies and associations for the top 3 SNPs in subgroup analysis of mild/moderate/severe PACG cases versus controls.

SNP	CHR	MA	MAF control	Mild (N = 22)			Moderate (N = 10)			Severe (N = 19)
				MAF		OR (95% CI)	MAF		OR (95% CI)	MAF		OR (95% CI)
rs1676486	1	A	0.19	0.2	0.797	1.098 (0.540–2.233)	0.45	0.018	2.416 (1.284–4.544)	0.39	0.011	2.119 (1.204–3.729)
rs3753841	1	G	0.26	0.23	0.722	0.892 (0.471–1.687)	0.55	0.009	2.158 (1.287–3.618)	0.5	0.006	1.962 (1.239–3.106)
rs12138977	1	C	0.18	0.14	0.549	0.773 (0.329–1.814)	0.45	0.007	2.550 (1.344–4.839)	0.45	0.001	2.535 (1.465–4.386)

Chi-square tests and logistic regression were used.