Retinal and Corneal Toxicity and Pharmacokinetic Analysis of Intraocular Injection of Ganciclovir in Rabbit Eyes

Figure 10

Transmission electron microscopy of the retina of a rabbit eye on the first day after intravitreal injection of 2 mg/0.1 mL GCV. (a, b) All retinal layers exhibited significant edema at different magnifications. (c) Bubble-like structures were found in the retinal nerve fiber layer. (d, e) The intercellular space was dilated in the inner/outer nuclear layer. (f) Photoreceptors were swollen and loosely arranged, and photoreceptor outer segments were decreased in number.

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