Journal of Ophthalmology / 2019 / Article / Tab 1

Review Article

Timolol 0.1% in Glaucomatous Patients: Efficacy, Tolerance, and Quality of Life

Table 1

Therapeutic efficacy of 0.1% timolol gel.

Ref.No. of patientsMethodsIOP changes (%)IOP change (mmHg)Conclusion

222101st line compared to 0.5% timolol solution−27% after 12 weeks
()
−6.3/−7No difference between treatment
()
32175 (350 eyes)1st line preservative-free 0.1% timolol gel vs 0.1% timogel gel with preservative−31% after 12 weeks−5.63/
−5.63
Comparable in both groups (NS)
3368 (110 eyes)1st line or replacement for 0.5% timolol solution or combination with latanoprost−27% at 6 month
additional drop
−13% total drop −38%
−6.3
−2.6
−11, 3


341111st line (53 pts) or replacement for a beta-blocker (58 pts)−25% at 12 weeks
additional drop −13%
−6
−3.41

3586 (119 eyes)1st line (53 pts) or replacement for a poorly tolerated or ineffective beta-blocker (33 pts)−25% at 3 months additional fall
−11% after 3 months
−9.1
−4.5
Comparable efficacy to timolol 0.5%
3630 (54 eyes)Replacement for latanosprost due to poor compliance−30% on latanoprost
−25% on timolol gel
16.15
–16.5
Comparable efficacy
37551st line—comparison of 0.1% timolol gel and solutionIOP reduction 1 to 2 mmHg greater with the gel formulation ()

Ref. = reference; No. = number; IOP = intraocular pressure; p = p value.

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