Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration

Table 1

Overview of pharmacological models for retinal degeneration.

Substance	Disease	Affected cell types	Cell death	Animal mode
NMDA	Glaucoma	RGC	Apoptosis	Chick [25, 26], carp [27, 28], mudpuppy [29, 30], avian [31], turtle [32, 33], mouse, rat [34, 35], rabbit [36, 37], cat [38], bovine [39], and zebrafish [40, 41]
MNU	Retinitis pigmentosa	Photoreceptor	Apoptosis; Apoptosis/necrosis	Mouse [42–44], rat [45–47], hamsters [48], rabbit [49], pig [50], cat [51], shrew [52], and monkey [53]
NAIO3	AMD	RPE (primary); photoreceptor (secondary)	Apoptosis	Mice [42, 54], rat [55, 56], cat [57], rabbit [58, 59], sheep [60], pig [61], and monkey [62]
STZ	DR	Perithelial cell	Necrosis	Mice [63, 64], rat [65, 66], zebrafish [67, 68], rabbit [69], dog [70], monkey [71], and pig [72, 73]