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Journal of Ophthalmology
Volume 2019, Article ID 5970659, 6 pages
Research Article

Risk Factors for Persistent or Recurrent Central Serous Chorioretinopathy

Jia Yu,1,2,3,4 Gezhi Xu,1,2,3,4 Qing Chang,1,2,3,4 Xiaofeng Ye,1,2,3,4 Lei Li,1,2,3,4 Chunhui Jiang,1,2,3,4 and Qi Zhao5

1Department of Ophthalmology, Eye & Ear Nose Throat Hospital of Fudan University, Shanghai 200031, China
2Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China
3NHC Key Laboratory of Myopia (Fudan University), Shanghai 200031, China
4Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai 200031, China
5Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China

Correspondence should be addressed to Qing Chang; moc.nuyila@gnahcgnq

Received 25 December 2018; Revised 23 May 2019; Accepted 11 June 2019; Published 14 August 2019

Academic Editor: Enrico Peiretti

Copyright © 2019 Jia Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To investigate the risk factors for persistent or recurrent central serous chorioretinopathy (CSC). Materials and Methods. Consecutive treatment-naïve CSC patients were included from January 2017 to October 2018. All patients were asked to complete questionnaires, addressing previously described risk factors for the development of CSC. Patients were divided into two groups: those with acute CSC, who were in the first episode, with spontaneous resolution of subretinal fluid within 3 months, and with no recurrence within 1 year; and those with persistent or recurrent CSC, the remaining patients. Results. In total, 138 patients were enrolled: 20 (14.5%) with acute CSC and 118 (85.5%) with persistent or recurrent CSC. Using multivariate analysis, male sex (odds ratio (OR), 95% confidence interval: 5.63 [1.02–31.02]; ), older age (OR: 1.14 [1.03–1.25]; ), and higher Insomnia Severity Index score (OR: 1.30 [1.05–1.60]; ) were found to be independently associated with persistent or recurrent CSC. Conclusions. Male sex, age, and sleep disorders are risk factors for persistent or recurrent CSC in the natural history. These patients may require early photodynamic therapy. Treatment for sleep disorders is strongly recommended. All CSC patients may require careful and periodic follow-up.