Repressed Wnt Signaling Accelerates the Aging Process in Mouse Eyes

Figure 5

Exfoliation-like material is LOXL1-positive. LOXL1 immunostaining of control corneas (a) revealed LOXL1-positive bands on the corneal endothelium (a, c). KR/sFRP1 corneas exhibited increased LOXL1 expression in the corneal epithelium. LOXL1-positive aggregates can be found in the anterior chamber (arrow in b). These findings are highly consistent with PEX syndrome phenotypes.