Notch Signaling Pathway Is Involved in bFGF-Induced Corneal Lymphangiogenesis and Hemangiogenesis

Figure 1

bFGF-induced lymphangiogenesis and hemangiogenesis. (a) Control group: microscopic pictures of corneal neovascularization were examined on days 1, 3, 7, and 14 after PBS pellet implantation (). bFGF group: microscopic pictures of corneal neovascularization were examined on days 1, 3, 7, and 14 after bFGF pellet implantation () (bar, 1000 μm). Sites of pellet implantation. (b) bFGF group: the staining of corneal flat mounts for hemangiogenesis (CD31, green) were examined on days 1, 3, 7, and 14 after bFGF or PBS pellet implantation () (bar, 200 μm). (c) bFGF group: the staining of corneal flat mounts for lymphangiogenesis (LYVE-1, red) was examined on days 1, 3, 7, and 14 after bFGF or PBS pellet implantation () (bar, 400 μm). (d) Quantitative analysis of lymphangiogenesis and hemangiogenesis on the indicated days after PBS implantation (n = 4–6) (). Quantitative analysis of lymphangiogenesis and hemangiogenesis on the indicated days after bFGF implantation (n = 5–8). ; .

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