Multiple Gene Polymorphisms Associated with Exfoliation Syndrome in the Uygur Population

Table 3

Allele association analysis with these SNPs.

SNP	XFS/XFG	Control			OR (95% CI)
TBC1D21
rs16958445
Allele
G	432	583	3.025	0.082	1.369 (0.960–1.953)
A	70	69
ATXN2
rs7137828
Allele
T	429	531	3.272	0.070	0.7467 (0.544–1.025)
C	73	121
APOE
rs429358
Allele
T	452	587
C	50	65	<0.001	0.996	0.999 (0.677–1.473)
rs7412
Allele
C	468	610
T	34	42	0.051	0.822	1.055 (0.661–1.685)
CLU
rs2279590
Allele
C	351	455
T	151	197	0.002	0.961	0.994 (0.771–1.280)
AFAP1
rs11732100
Allele
C	402	524
T	100	128	0.015	0.903	1.018 (0.760–1.364)
TXNRD2
rs35934224
Allele
C	446	574
T	56	78	0.180	0.671	0.924 (0.642–1.331)
CACNA1A
rs4926244
Allele
T	401	515
C	101	137	0.138	0.710	0.947 (0.710–1.263)
ABCA1
rs2472493
Allele
A	301	391
G	201	261	<0.001	0.998	1.000 (0.789–1.269)
LOXL1
rs41435250
Allele
G	379	552
T	123	100	15.280	<0.001	1.791 (1.334–2.405)
rs893818
Allele
G	418	442
A	84	210	35.780	<0.001	0.423 (0.318–0.563)
GAS7
rs9897123
Allele
C	249	341
T	253	311	0.827	0.363	1.114 (0.883–1.406)
CNTNAP2
rs2107856
Allele
G	299	390
T	203	262	0.008	0.930	1.011 (0.797–1.281)
rs2141388
Allele
C	301	391
T	201	261	<0.001	0.998	1.000 (0.789–1.269)

G allele of rs41435250 of LOXL1 was the risk allele for the disorder. In contrast, G allele of rs893818 of LOXL1 was the protective allele for the disorder. Other alleles of SNPs showed no statistical significance.