Multiple Gene Polymorphisms Associated with Exfoliation Syndrome in the Uygur Population
Table 4
Genotype association analysis with these SNPs.
Gene/SNP
XFS/XFG
Control
p
OR (95% CI)
Adjusted-P
Adjusted-OR (95% CI)
TBC1D21
rs16958445
Genotype
GG
189
259
0.532
1.138 (0.758–1.71)
0.114
1.465 (0.913–2.351)
GA
54
65
0.033
5.481 (1.151–26.110)
0.043
5.439 (1.053–28.090)
AA
8
2
ATXN2
rs7137828
Genotype
TT
183
224
0.705
0.929 (0.635–1.360)
0.955
1.013 (0.654–1.569)
TC
63
83
0.027
0.322 (0.118–0.879)
0.030
0.299 (0.100–0.891)
CC
5
19
APOE
rs429358
Genotype
TT
202
263
0.910
1.025 (0.673–1.560)
0.532
1.171 (0.714–1.920)
TC
48
61
0.727
0.651 (0.059–7.230)
0.773
0.697 (0.060–8.091)
CC
1
2
rs7412
Genotype
CC
219
286
0.907
1.031 (0.619–1.717)
0.873
1.049 (0.585–1.882)
CT
30
38
0.790
1.306 (0.183–9.344)
0.887
1.172 (0.132–10.400)
TT
2
2
CLU
rs2279590
Genotype
CC
126
159
0.604
0.912 (0.644–1.292)
0.298
0.807 (0.538–1.209)
CT
99
137
0.760
1.094 (0.616–1.943)
0.171
1.586 (0.819–3.071)
TT
26
30
AFAP1
rs11732100
Genotype
CC
162
208
0.678
0.927 (0.649–1.324)
0.922
0.979 (0.650–1.477)
CT
78
108
0.442
1.412 (0.585–3.407)
0.576
0.711 (0.215–2.350)
TT
11
10
TXNRD2
rs35934224
Genotype
CC
203
252
0.118
0.709 (0.461–1.091)
0.175
0.710 (0.433–1.165)
CT
40
70
0.142
2.483 (0.737–8.362)
0.258
2.245 (0.553–9.114)
TT
8
4
CACNA1A
rs4926244
Genotype
TT
165
205
0.349
0.840 (0.584–1.209)
0.224
0.774 (0.512–1.170)
TC
71
105
0.684
1.165 (0.559–2.426)
0.826
0.901 (0.356–2.282)
CC
15
16
ABCA1
rs2472493
Genotype
AA
91
115
0.713
0.934 (0.650–1.343)
0.831
0.955 (0.626–1.457)
AG
119
161
0.888
1.036 (0.631–1.702)
0.906
0.966 (0.544–1.716)
GG
41
50
LOXL1
rs41435250
Genotype
GG
145
233
0.006
1.663 (1.158–2.388)
0.071
1.478 (0.966–2.259)
GT
89
86
0.003
3.902 (1.580–9.640)
0.003
5.276 (1.748–15.930)
TT
17
7
rs893818
Genotype
GG
171
154
<0.001
0.511 (0.358–0.729)
<0.001
0.4449 (0.293–0.676)
GA
76
134
<0.001
0.095 (0.033–0.272)
<0.001
0.119 (0.039–0.356)
AA
4
38
GAS7
rs9897123
Genotype
CC
62
82
0.739
0.934 (0.625–1.396)
0.440
0.833 (0.523–1.325)
CT
125
177
0.335
1.263 (0.785–2.033)
0.808
0.935 (0.542–1.612)
TT
64
67
CNTNAP2
rs2107856
Genotype
GG
89
117
0.917
1.02 (0.709–1.467)
0.687
1.091 (0.715–1.665)
GT
121
156
0.947
1.017 (0.622–1.664)
0.537
1.194 (0.681–2.094)
TT
41
53
rs2141388
Genotype
CC
91
118
0.981
0.996 (0.692–1.431)
0.772
1.064 (0.698–1.624)
CT
119
155
0.990
1.003 (0.614–1.639)
0.570
1.177 (0.672–2.060)
TT
41
53
The genotypes AA for rs16958445 of TBC1D21 and GG/TT for rs41435250 of LOXL1 were risk genotypes for the disease. The genotypes CC for rs7137828 of ATXN2 and GG/AA for rs893818 of LOXL1 were protective genotypes for the disease.
