Research Article
Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration
Table 2
Functional analysis for the DEGs in in RPE/choroid between AMD patients and age-matched healthy controls.
| Top diseases and biological functions | valuea | No. of genes |
| Diseases and disorders | Cancer | 5.96E-16-2.41E-03 | 299 | Organismal injury and abnormalities | 5.96E-16-2.41E-03 | 301 | Ophthalmic disease | 9.88E-16-2.26E-03 | 58 | Hereditary disorder | 2.26E-15-2.26E-03 | 75 | Neurological disease | 2.26E-15-2.17E-03 | 126 |
| Molecular and cellular functions | Cell morphology | 1.01E-12-2.19E-03 | 56 | Cellular movement | 1.82E-10-2.19E-03 | 84 | Cellular compromise | 6.25E-10-1.88E-03 | 27 | Cellular development | 1.48E-09-2.25E-03 | 32 | Cellular growth and proliferation | 1.48E-09-2.25E-03 | 46 |
| Physiological system development and function | Nervous system development and function | 7.04E-14-1.88E-03 | 88 | Embryonic development | 1.01E-12-2.06E-03 | 55 | Organ development | 1.01E-12-1.86E-03 | 48 | Organ morphology | 1.01E-12-1.69E-03 | 58 | Organismal development | 1.01E-12-2.37E-03 | 87 |
|
|
aRange of p values indicates a higher level functions that contained multiple lower level functions.
|