Comparative Results of “Epi-Off” Conventional versus “Epi-Off” Accelerated Cross-Linking Procedure at 5-year Follow-Up

Table 3

Topographical parameter evolution in both groups.

Parameter		S-CXL	value compared to baseline	A-CXL	value compared to baseline	value between groups
TP	Preoperative	462.419 ± 34.36		463.565 ± 35.53		0.832
	1 year	445.698 ± 38.90	0.0022	450.052 ± 33.34	0.0168	0.4416
	2 years	444.043 ± 38.98	0.0008	447.223 ± 33.25	0.0039	0.574
	3 years	442.677 ± 38.9	0.0003	441.527 ± 41.7	0.0006	0.8532
	4 years	441.419 ± 38.97	0.0001	441.263 ± 42.02	0.0006	0.9863
	5 years	441.15 ± 38.9	0.0001	441.132 ± 42.23	0.0006	0.9518
Vol C	Preoperative	57.452 ± 6.55		57.069 ± 3.46		0.6463
	1 year	56.173 ± 6.55	0.018	55.803 ± 3.28	0.0221	0.6547
	2 years	56.136 ± 6.53	0.0179	55.464 ± 3.27	0.0038	0.4151
	3 years	56.103 ± 6.55	0.0162	55.064 ± 3.63	0.0007	0.2182
	4 years	56.104 ± 6.55	0.0162	55.059 ± 3.64	0.0006	0.2179
	5 years	56.093 ± 6.56	0.0159	55.058 ± 3.64	0.0006	0.2236
IVA	Preoperative	0.900 ± 0.41		1.001 ± 0.32		0.0825
	1 year	0.760 ± 0.4	0.0199	0.851 ± 0.32	0.005	0.1149
	2 years	0.752 ± 0.39	0.0123	0.843 ± 0.32	0.0028	0.0851
	3 years	0.743 ± 0.41	<0.0001	0.832 ± 0.34	0.0015	0.1131
	4 years	0.735 ± 0.4	<0.0001	0.821 ± 0.34	0.0008	0.115
	5 years	0.730 ± 0.41	<0.0001	0.815 ± 0.32	0.0004	0.217
ISV	Preoperative	79.354 ± 29.53		89.578 ± 27.53		0.222
	1 year	75.569 ± 29.57	0.0383	84.078 ± 26.84	0.0214	0.0541
	2 years	74.58 ± 29.55	0.0271	82.165 ± 26.22	0.0091	0.0892
	3 years	73.741 ± 29.58	0.0197	81.066 ± 26.67	0.0055	0.0964
	4 years	73.661 ± 29.59	0.0154	80.889 ± 26.44	0.0558	0.0731
	5 years	73.466 ± 29.6	0.0124	80.678 ± 26.84	0.0558	0.057
IHA	Preoperative	30.817 ± 21.3		34.315 ± 23.59		0.3141
	1 year	27.439 ± 20.57	0.0262	29.074 ± 20.15	0.0215	0.8265
	2 years	27.083 ± 20.41	0.0223	28.774 ± 21.25	0.0219	0.7823
	3 years	26.801 ± 20.35	0.019	28.362 ± 20.63	0.0103	0.6216
	4 years	26.553 ± 20.3	0.0164	28.023 ± 21.02	0.0101	0.6782
	5 years	26.315 ± 20.28	0.0141	27.974 ± 21.22	0.0101	0.7348
BAD_D	Preoperative	7.806 ± 3.15		8.663 ± 2.15		0.455
	1 year	7.593 ± 3.14	0.0445	8.220 ± 2.22	0.0397	0.1372
	2 years	7.548 ± 3.15	0.0057	8.170 ± 2.08	0.0352	0.1409
	3 years	7.51 ± 3.15	0.0152	8.150 ± 2.19	0.0164	0.13
	4 years	7.481 ± 3.15	0.0148	8.109 ± 2.38	0.0134	0.1136
	5 years	7.462 ± 3.18	0.0045	8.048 ± 2.07	0.0088	0.1064
ART Max	Preoperative	175.021 ± 67.32		169.881 ± 55.36		0.594
	1 year	163.892 ± 66.99	0.2599	152.052 ± 48.59	0.0365	0.1994
	2 years	161.924 ± 66.99	0.1852	148.644 ± 48.68	0.0131	0.1506
	3 years	160.451 ± 67.09	0.141	146.292 ± 48.34	0.0026	0.0763
	4 years	159.344 ± 67.07	0.1133	145.287 ± 48.08	0.0026	0.0918
	5 years	158.86 ± 67.12	0.1028	144.092 ± 48.12	0.0026	0.1093