Atropine 0.01% for the Control of Myopia in Chinese Children: Effect on Accommodation Functions and Pupil Size
Table 3
Ophthalmological parameters at follow-up visits†.
Atropine group
Control group
value
Mean (SD), n = 37
Mean (SD), n = 24
Spherical equivalent (D)
Mean change over 6 mos
−0.30 (0.42)
−0.60 (0.43)
<0.001
Axial length (mm)
Mean change over 3 mos
0.12 (0.12)
0.19 (0.14)
0.004
Mean change over 6 mos
0.24 (0.16)
0.35 (0.20)
0.001
Accommodation amplitude (D)
Monocular
Mean change over 3 mos
0.5 (2.7)
0.7 (2.1)
0.75
Mean change over 6 mos
0.6 (2.2)
0.5 (2.3)
0.80
Binocular
Mean change over 3 mos
0.1 (2.1)
0.3 (1.8)
0.62
Mean change over 6 mos
−0.2 (1.9)
0.1 (2.3)
0.57
Accommodation facility (cpm)
Monocular
Mean change over 3 mos
2.0 (3.3)
3.7 (3.0)
<0.01
Mean change over 6 mos
4.2 (4.0)
5.7 (3.6)
0.03
Binocular
Mean change over 3 mos
1.7 (3.6)
3.5 (3.1)
0.03
Mean change over 6 mos
4.0 (4.0)
5.0 (3.5)
0.29
Pupil diameter (mm)
Mean change over 3 mos
0.8 (0.7)
−0.1 (0.5)
<0.01
Mean change over 6 mos
0.7 (0.7)
0.1 (0.5)
0.01
Near BCVA (logMAR)
Mean change over 3 mos
0.00 (0.00)
0 (0.00)
-
Mean change over 6 mos
0.00 (0.00)
0 (0.00)
-
Distant BCVA (logMAR)
Mean change over 3 mos
−0.01 (0.02)
−0.00 (0.01)
0.62
Mean change over 6 mos
−0.00 (0.02)
−0.00 (0.02)
0.57
Near stereoacuity (log (seconds of arc))
Mean change over 3 mos
0.0 (0.2)
0.0 (0.1)
0.22
Mean change over 6 mos
0.0 (0.2)
0.0 (0.1)
0.82
Intraocular pressure (mmHg)
Mean change over 3 mos
0.6 (2.5)
0.2 (2.0)
0.37
Mean change over 6 mos
−0.3 (2.8)
0.1 (2.6)
0.52
D = diopter; BCVA = best-corrected visual acuity; logMAR = logarithm of the minimum angle of resolution; cpm = cycles per minute. †Repeated-measure analyses were performed for the ophthalmic parameters, with treatment group, time, and the interaction between time and group included in the model. Significant at 0.05.