Clinical Study

Atropine 0.01% for the Control of Myopia in Chinese Children: Effect on Accommodation Functions and Pupil Size

Table 3

Ophthalmological parameters at follow-up visits†.

Atropine groupControl group value
Mean (SD), n = 37Mean (SD), n = 24

Spherical equivalent (D)
 Mean change over 6 mos−0.30 (0.42)−0.60 (0.43)<0.001
Axial length (mm)
 Mean change over 3 mos0.12 (0.12)0.19 (0.14)0.004
 Mean change over 6 mos0.24 (0.16)0.35 (0.20)0.001
Accommodation amplitude (D)
 Monocular
  Mean change over 3 mos0.5 (2.7)0.7 (2.1)0.75
  Mean change over 6 mos0.6 (2.2)0.5 (2.3)0.80
 Binocular
  Mean change over 3 mos0.1 (2.1)0.3 (1.8)0.62
  Mean change over 6 mos−0.2 (1.9)0.1 (2.3)0.57
Accommodation facility (cpm)
 Monocular
  Mean change over 3 mos2.0 (3.3)3.7 (3.0)<0.01
  Mean change over 6 mos4.2 (4.0)5.7 (3.6)0.03
 Binocular
  Mean change over 3 mos1.7 (3.6)3.5 (3.1)0.03
  Mean change over 6 mos4.0 (4.0)5.0 (3.5)0.29
Pupil diameter (mm)
 Mean change over 3 mos0.8 (0.7)−0.1 (0.5)<0.01
 Mean change over 6 mos0.7 (0.7)0.1 (0.5)0.01
Near BCVA (logMAR)
 Mean change over 3 mos0.00 (0.00)0 (0.00)-
 Mean change over 6 mos0.00 (0.00)0 (0.00)-
Distant BCVA (logMAR)
 Mean change over 3 mos−0.01 (0.02)−0.00 (0.01)0.62
 Mean change over 6 mos−0.00 (0.02)−0.00 (0.02)0.57
Near stereoacuity (log (seconds of arc))
 Mean change over 3 mos0.0 (0.2)0.0 (0.1)0.22
 Mean change over 6 mos0.0 (0.2)0.0 (0.1)0.82
Intraocular pressure (mmHg)
 Mean change over 3 mos0.6 (2.5)0.2 (2.0)0.37
 Mean change over 6 mos−0.3 (2.8)0.1 (2.6)0.52

D = diopter; BCVA = best-corrected visual acuity; logMAR = logarithm of the minimum angle of resolution; cpm = cycles per minute. Repeated-measure analyses were performed for the ophthalmic parameters, with treatment group, time, and the interaction between time and group included in the model. Significant at 0.05.