Review Article

Does Cataract Surgery Improve the Progression of Age-Related Macular Degeneration? A Meta-Analysis

Table 1

Characteristics of articles included in this meta-analysis.

AuthorPublish yearStudy designNo. of cases/controlLocationAdjustment/matchAMD classificationFollow-upOR/RR/HRCIAge

Pollack1996Cohort47/47AsiaEarly AMD1 yearRR = 4.5001.027–19.7260.05480.4 (67–94)

Lintje Ho2008Cohort6032EuropeAge, sex, follow-up time, and the correlation between eyesAMD5.7 (2.8–9.7)OR = 1.260.85–1.86≥55
Early AMDOR = 1.310.88–1.95
Dry AMDOR = 3.441.68–7.08
Wet AMDOR = 0.930.35–2.49

Jie Jin Wang2003Cohort6019Oceania and North America (BDES and BMES)Baseline age, gender, smoking status (current, past, and never), and preexisting early-stage ARM lesions at baselineLate AMD5 yearsOR = 5.72.4–13.6
Dry AMDOR = 4.51.4–14.7
Wet AMDOR = 4.91.9–12.4
North America (BDES)Late AMDOR = 7.32.6–20.4
Dry AMDOR = 4.71.4–16.1
Wet AMDOR = 6.81.9–24.3
Oceania (BMES)Late AMDOR = 4.21.0–17.5
Dry AMDOR = 7.61.1–55.0
Wet AMDOR = 3.10.7–13.2

Sudha Cugati2006Cohort1952Oceania (BMES)Age, gender, smokingEarly AMD10 yearsOR = 1.250.69–2.25≥49
Age, gender, smoking, and presence of early ARM lesionsLate AMDOR = 3.311.11–9.87
Dry AMDOR = 2.340.51–10.8
Wet AMDOR = 3.421.07–10.91

Jau-Der Ho2018Cohort3465/10395AsiaPatient’s geographical location, urbanization level, monthly income, diabetes, hypertension, and cardiovascular and hyperlipidaemiaWet AMD5 yearsHR = 2.681.55–4.66<0.0170.2 ± 9.6

Helena Buch2005Cohort359EuropeAge, sexAMD14 yearsOR = 1.30.7–2.482.4 ± 4.63 (75–95)
Late AMDOR = 1.60.8–3.2

Emily Y. Chew2009Cohort6037America (AREDS)Age, gender, race, smoking, AREDS treatment group, and eye-specific AMD severity statusWet AMD5 yearsOR = 0.760.44–1.300.3155–80
Dry MDOR = 0.550.31–0.990.047

Jie Jin Wang2012Cohort1178Oceania (CSAMD)Baseline early AMD in models for late AMD outcome (paired comparison)Late AMD3 yearsOR = 0.740.23–2.36≥65
Early AMDOR = 1.070.74–1.65
Jie Jin Wang2016Cohort2029Baseline early AMD in models for late AMD outcome (paired comparison)Late AMD5 yearsOR = 0.70.4–1.2
Early AMDOR = 0.70.5–1.1

Ronald Klein2002Cohort2764North America (BDES)Age, sex, vitamin use, smoking, drinking, and systolic blood pressureAMD10 yearsRR = 1.971.29–3.02<0.0143–86
Early AMDRR = 1.360.82–2.230.23
Late AMDRR = 3.811.89–7.69<0.01
Wet AMDRR = 4.311.71–10.9<0.01
Dry AMDRR = 3.181.33–7.60<0.01

Klein, B. E.2012Cohort3275North America (BDES)Age, sex, education, smoking, drinking, cardiovascular disease, diabetes, and diastolic blood pressureEarly AMD20 yearsOR = 1.060.81–1.380.743–86
3585Late AMDOR = 1.961.28–3.020.002

Ronald Klein1998Cohort3684North America (BDES)Age, smoking, beer consumption, drinking, pulse pressure, hypertension, and vitamin useEarly AMD5 yearsOR = 1.730.93–3.210.0843–86
Late AMDOR = 2.801.03–7.630.04≥65
Wet AMDOR = 1.670.39–7.180.49≥65
Dry AMDOR = 3.490.80–15.160.1≥65
AMDOR = 2.571.61–4.11<0.00143–86