Fixed Regimen Treatment in Unselected Naïve Patients Cohort with Neovascular Age-Related Macular Degeneration

Table 2

Prevalence of eyes with hemorrhage, RPE atrophy, subretinal fibrosis, and dry macula at baseline, after the loading dose (LD), and at final follow-up period (12 mo).

	Baseline n (%)	LD n (%)	pa	12 mo n (%)	pb	pc
Hemorrhage	54 (43.9)	20 (16.3)	<0.0001	10 (8.1)	0.0782	<0.0001
RPE atrophy	13 (10.6)	32 (26.0)	0.0027	45 (35.6)	0.0986	<0.0001
Fibrosis	3 (2.4)	9 (7.3)	0.1361	16 (13.0)	0.2048	0.0031
Dry macula	12 (9.8)	76 (61.8)	<0.0001	83 (67.5)	1	<0.0001

RPE: retinal pigment epithelium; LD: loading dose; 12 mo: final follow-up; n(%), number of eyes (percentage), pa: differences baseline vs. LD; pb: differences LD vs. 12 mo; and pc: differences baseline vs. 12 mo.