The Role of Intravitreal Anti-VEGF Agents in Rabbit Eye Model of Open-Globe Injury

Figure 2

B-ultrasonic exam of rabbit eyes at 28 days after open-globe injury. (a) For anti-VEGF treatments, Ranibizumab or Conbercept was injected intravitreally at 0.5 hours after OGI. B scan and histopathological examinations were performed 28 days after OGI. (b) There was no abnormal echo in normal rabbit eyes. (c) Vitreous opacity and strands (white arrow) were detected in rabbit eyes with stage 1 intravitreal proliferation. (d) Vitreous opacity and epiretinal membrane formation (white arrow) were observed in rabbit eyes with stage 2 intravitreal proliferation, without any sign of retinal detachment. (e) Distribution diagram of proliferation stage in OGI, RBZ, and CNB groups. RBZ, OGI with intravitreal Ranibizumab; CNB, OGI with intravitreal Conbercept.

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