Casein Kinase 2-Interacting Protein-1 Alleviates High Glucose-Reduced Autophagy, Oxidative Stress, and Apoptosis in Retinal Pigment Epithelial Cells via Activating the p62/KEAP1/NRF2 Signaling Pathway

Figure 1

CKIP-1 expression is reduced in high glucose-triggered ARPE-19 cells. The mRNA (a) and protein (b) and (c) expressions of CKIP-1 were detected by RT-PCR and Western blots, respectively. (d) ROS generation was measured by the ROS kit.  < 0.001 vs. NG. NG, normal glucose (5.5 mM); MG, mannitol (20 mM); HG, high glucose (25 mM).

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