|
| Disease | Main changes |
|
| Cataract | Lower surface roughness in the anterior side of the ALC and higher surface roughness in their posterior side |
| Lower Young’s modulus |
| Ultrastructure morphology changes in intumescent white cataracts |
| Trypan blue staining | Decrease in elasticity and an increase in stiffness |
| No difference in CCC strength |
| Aniridia | Thinner and more fragile |
| Degenerative changes (degeneration, necrosis, and loss) and proliferative changes (proliferation and double layer) of the lens epithelium |
| Climatic droplet keratopathy | Plateau or “bag” or herniation-like of the lens capsule |
| Exfoliation syndrome | Abnormal fibrillar extracellular material deposition |
| Diffuse intracellular and extracelluar edema, transparent vacuoles, apoptotic cells, and destroyed epithelial cells |
| More affinity to trypan blue |
| True exfoliation syndrome | Thickened delaminated structure, perpendicular fibrils, and vesicular degeneration in the ALC |
| Double delamination and pigment deposition on the detached membrane |
| Alport syndrome | Marked thinning and vertical dehiscence of the ALC |
| Spontaneous rupture of the ALC |
| Silicone oil tamponade | Surface irregularities, pits, and depressions in the posterior surface of the ALC |
| LECs with apoptotic changes and cytoplasmic vacuoles |
| Increased mechanical resistance of the ALC |
|
