|
| Connexin type | Angiogenic factors | Comment |
|
| Cx43 | VEGF [32] | Cx43 facilitated the transport of VEGF from glioblastoma to endothelial cells |
| Cx43 GJ | VEGF [31] | BM-MNC promoted VEGF uptake into HUVEC through gap junction-mediated pathway |
| CX43 HC | VEGF [22] | Inhibition of Cx43 prevented the release of VEGF from human adult retinal pigment epithelial cells |
| Cx43 HC and GJ | VEGF [38] | Inhibition of Cx43 upregulated VEGF mRNA expression |
| Cx43 GJ | VEGF [39] | Inhibition of Cx43 blocked the effect of VEGF on endothelial progenitor cells homing and reendothelialization |
| Cx43 | VEGF [24, 25] | Suppression of Cx43 reduced VEGF secretion from human endometrial stromal cells |
| Cx43 | VEGF [36] | Suppression of Cx43 expression in human breast cancer cells increased VEGF expression |
| Cx43 | VEGF [40] | Inhibition of Cx43 gap junction function upregulated mRNA and protein expression of VEGF in gingival fibroblasts |
| Cx43 | VEGF [23] | During oxidative stress conditions, overexpression of Cx43 in retinal pigment epithelial cells reduced gene and protein expression of VEGF |
| Cx43 | VEGF [35] | Downregulation of Cx43 alleviated angiogenesis and VEGF secretion from endothelial progenitor cells |
| Cx43 | VEGF [37] | Downregulation of Cx43 in tumor cells promoted VEGF expression leading to angiogenesis |
| Cx43 | VEGF [28] | Suppression of Cx43 expression in mouse brain microvascular endothelial cells reduced the expression of VEGF |
| Cx43 | bFGF [41] | Downregulation of Cx43 expression decreased bFGF expression in prolactinoma cells |
| Cx43 | bFGF and VEGF [42] | Overexpression of Cx43 in MSCs promoted the release of VEGF and bFGF from infarcted heart |
| Cx43 | MMP2 and MMP9 [43] | Inhibition of the function of Cx43 in HUVECs downregulated MMP2 and MMP9 expression |
| Cx43 | MMP9 [44] | Inhibition of Cx43 reduced MMP9 expression in MDA-MB-231 breast cancer cells |
| Cx43 | Claudin-5 and ZO-1 [45] | Downregulation of Cx43 decreased the expression of Claudin-5 and ZO-1, thus increasing vascular permeability |
| Cx43 | Claudin-5 and ZO-1 [28] | Cx43 stabilized blood vessels during chronic cerebral hypoperfusion. The expression of ZO-1 and Claudin-5 in Cx43+/− mice was downregulated |
| Cx43 | Claudin-5 and ZO-1 [46] | Overexpression of Cx43 promoted vascular growth and vascular leakage |
| Cx43 | VE-cadherin [47] | Downregulating Cx43 increased vascular leakage by decreasing expression of VE-cadherin |
|
