Journal of Ophthalmology

Zeaxanthin and Lutein in the Management of Eye Diseases


Status
Published

Lead Editor

1Chung Shan Medical University, Taichung, Taiwan

2Fordham University, New York, USA

3Nanjing Medical University, Nanjing, China

4University of Florida, Florida, USA

5Jagiellonian University in Krakow, Krakow, Poland


Zeaxanthin and Lutein in the Management of Eye Diseases

Description

Zeaxanthin and lutein, two carotenoid pigments of the xanthophyll subclass, are present in a high concentration in the retina, especially in the macular area. They work as a filter protecting the macula from the blue light and also as an antioxidant and free radical scavenger to reduce oxidative stress-induced damage in the eye. Many observational and interventional studies have indicated that lutein and zeaxanthin might reduce the risk of various eye diseases, especially the age-related macular degeneration. In vitro and in vivo studies indicated that they can protect various ocular cells against oxidative damage.

Recent studies have shown that, in addition to traditional mechanisms, lutein and zeaxanthin can influence the viability and function of cells through various signal pathways or transcription factors; for example, they can affect immune responses and inflammation, inhibit laser-induced choroidal revascularization and hypoxia-induced accumulation of VEGF in ocular cells, and also have anticancer effects in several malignant tumors, such as uveal melanoma. This special issue will collect the results of recent studies regarding the effects of lutein, zeaxanthin, and relevant carotenoids, such as mesozeaxanthin and astaxanthin, on the eye in different in vivo or in vitro experimental models and the results of management of various ocular diseases by these molecules.

Potential topics include, but are not limited to:

  • Chemistry and biochemistry of lutein and zeaxanthin related to their biofunctions in the eye
  • Bioavailability and metabolism of lutein and zeaxanthin related to the eye
  • Absorption, transport, and distribution of lutein and zeaxanthin and related carotenoids especially the levels of these carotenoids in various ocular tissues
  • Clinical measurement of macular pigment optic density in normal individuals and patients with various ocular diseases
  • Epidemiological studies on the food uptake and blood levels of lutein and zeaxanthin and their relationship with the occurrence of various ocular diseases
  • The photophysics and photobiology of lutein, zeaxanthin, and related carotenoids
  • The effects of lutein and zeaxanthin as a filter of blue light and as an antioxidant for protecting various ocular cells against oxidative stress-induced damage in vitro
  • Protective effects of lutein and zeaxanthin on experimental animal models with various ocular diseases
  • Effects of lutein and zeaxanthin on ocular immune reaction, inflammation, angiogenesis, and various ocular tumors in vitro or in the experiment animal eye models
  • Clinical effects of supplementation of lutein and zeaxanthin on visual performance
  • Clinical effects of supplementation of lutein and zeaxanthin in patients with various ocular diseases, including but not limited to age-related macular degeneration and cataract

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 4915916
  • - Editorial

Zeaxanthin and Lutein in the Management of Eye Diseases

Shun-Fa Yang | Joan E. Roberts | ... | Tadeusz Sarna
  • Special Issue
  • - Volume 2016
  • - Article ID 9035745
  • - Clinical Study

Increased Macular Pigment Optical Density and Visual Acuity following Consumption of a Buttermilk Drink Containing Lutein-Enriched Egg Yolks: A Randomized, Double-Blind, Placebo-Controlled Trial

Sanne M. van der Made | Elton R. Kelly | ... | Tos T. J. M. Berendschot
  • Special Issue
  • - Volume 2016
  • - Article ID 8341439
  • - Research Article

Effects of Lutein on Hyperosmoticity-Induced Upregulation of IL-6 in Cultured Corneal Epithelial Cells and Its Relevant Signal Pathways

Shih-Chun Chao | Chan-Wei Nien | ... | Hung-Yu Lin
  • Special Issue
  • - Volume 2016
  • - Article ID 8734309
  • - Research Article

Nonlethal Levels of Zeaxanthin Inhibit Cell Migration, Invasion, and Secretion of MMP-2 via NF-κB Pathway in Cultured Human Uveal Melanoma Cells

Ming-Chao Bi | Nicole Hose | ... | E. Song
  • Special Issue
  • - Volume 2016
  • - Article ID 3690140
  • - Review Article

Zeaxanthin: Review of Toxicological Data and Acceptable Daily Intake

James A. Edwards
  • Special Issue
  • - Volume 2015
  • - Article ID 865179
  • - Review Article

Lutein, Zeaxanthin, and meso-Zeaxanthin in the Clinical Management of Eye Disease

Nicole K. Scripsema | Dan-Ning Hu | Richard B. Rosen
  • Special Issue
  • - Volume 2015
  • - Article ID 687173
  • - Review Article

The Photobiology of Lutein and Zeaxanthin in the Eye

Joan E. Roberts | Jessica Dennison
  • Special Issue
  • - Volume 2015
  • - Article ID 392305
  • - Research Article

Effects of Zeaxanthin on Growth and Invasion of Human Uveal Melanoma in Nude Mouse Model

Xiaoliang L. Xu | Dan-Ning Hu | ... | Richard Rosen
  • Special Issue
  • - Volume 2015
  • - Article ID 523027
  • - Review Article

Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies?

Chunyan Xue | Richard Rosen | ... | Dan-Ning Hu
  • Special Issue
  • - Volume 2015
  • - Article ID 152854
  • - Research Article

Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways

Shih-Chun Chao | Tommaso Vagaggini | ... | Hung-Yu Lin
Journal of Ophthalmology
 Journal metrics
Acceptance rate36%
Submission to final decision73 days
Acceptance to publication31 days
CiteScore2.800
Impact Factor1.447
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