Journal of Ophthalmology

Retinal Degenerations: Genetics, Mechanism and Therapies


Publishing date
01 Jan 2011
Status
Published
Submission deadline
01 Jul 2010

Lead Editor

1Department of Ophthalmology, University of California, San Diego, La Jolla, CA 92093, USA

2Department of Ophthalmology, University of Alberta, Edmonton, AB, Canada AB T5H 3V9

3Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA


Retinal Degenerations: Genetics, Mechanism and Therapies

Description

Retinal degenerations are genetically heterogeneous and include a broad spectrum of phenotypes. Recent advances in biology and medicine have introduced new technologies to study the genetics of retinal degenerations and the mechanisms underlying their pathology. Knowledge and understanding of these conditions have led to the development of animal models, successful therapies, and novel tools to characterize these clinical conditions and provide better care to patients.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular pathology underlying retinal degenerations, the development of strategies to treat these conditions, and the evaluation of outcomes. We are particularly interested in articles describing the new modalities for clinical characterization of retinal dystrophies and measuring outcomes from treatment trials; advances in molecular genetics and molecular diagnostics; new insights into retinal degenerations using animal models; current concepts in the treatment of retinal degeneration using neuroprotection, small molecules, SiRNA, stem cells, and viral and nonviral gene therapy strategies.

Potential topics include, but not limited to:

  • Recent developments in inherited retinal degenerative disease research
  • Advances in genetics of retinal dystrophies
  • Latest technologies for clinical evaluation and measuring outcomes
  • Role of inflammation in retinal degeneration
  • Retinal disease mechanism using model systems
  • Role of modifiers in retinal dystrophies
  • Recent advances in ocular drug delivery

Before submission, authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jop/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 764873
  • - Editorial

Retinal Degenerations: Genetics, Mechanisms, and Therapies

Ian M. MacDonald | Muna I. Naash | Radha Ayyagari
  • Special Issue
  • - Volume 2011
  • - Article ID 531380
  • - Review Article

Variables and Strategies in Development of Therapeutic Post-Transcriptional Gene Silencing Agents

Jack M. Sullivan | Edwin H. Yau | ... | Heba E. Abdelmaksoud
  • Special Issue
  • - Volume 2011
  • - Article ID 906943
  • - Review Article

The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness

Kristina Narfström | Koren Holland Deckman | Marilyn Menotti-Raymond
  • Special Issue
  • - Volume 2011
  • - Article ID 806783
  • - Review Article

Conditional Gene Targeting: Dissecting the Cellular Mechanisms of Retinal Degenerations

Yun-Zheng Le
  • Special Issue
  • - Volume 2011
  • - Article ID 179412
  • - Review Article

Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside

Rajeshwari D. Koilkonda | John Guy
  • Special Issue
  • - Volume 2011
  • - Article ID 292040
  • - Review Article

Effects of Calcium Ion, Calpains, and Calcium Channel Blockers on Retinitis Pigmentosa

Mitsuru Nakazawa
  • Special Issue
  • - Volume 2011
  • - Article ID 417217
  • - Review Article

An Update on the Genetics of Usher Syndrome

José M. Millán | Elena Aller | ... | Carmen Ayuso
  • Special Issue
  • - Volume 2011
  • - Article ID 506137
  • - Review Article

Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection

Yoko Ozawa | Toshihide Kurihara | ... | Hideyuki Okano
  • Special Issue
  • - Volume 2011
  • - Article ID 391384
  • - Research Article

Mouse Model Resources for Vision Research

Jungyeon Won | Lan Ying Shi | ... | Patsy M. Nishina
  • Special Issue
  • - Volume 2011
  • - Article ID 753547
  • - Review Article

Current Concepts in the Treatment of Retinitis Pigmentosa

Maria A. Musarella | Ian M. MacDonald
Journal of Ophthalmology
 Journal metrics
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Acceptance rate10%
Submission to final decision129 days
Acceptance to publication18 days
CiteScore3.400
Journal Citation Indicator0.630
Impact Factor1.9
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