Journal of Ophthalmology

Genetic/Epigenetic Modulation, Ocular Diseases, and Therapeutic Prospective


Publishing date
22 Nov 2013
Status
Published
Submission deadline
05 Jul 2013

Lead Editor
Guest Editors

1Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA

2Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China


Genetic/Epigenetic Modulation, Ocular Diseases, and Therapeutic Prospective

Description

Complex eye diseases often have significant genetic components. Previous work exploring the genetic contributions of ocular diseases has implicated numerous genomic regions and a variety of candidate genes as the modulators of the disease susceptibility, including age-related macular degeneration, diabetic retinopathy, glaucoma, and high myopia. It is apparent that a significant portion of the heritability of ocular disease cannot be explained through these mechanisms. The field of epigenetics pursues the study of heritable changes in gene expression or cellular phenotypes caused by mechanisms other than changes in the underlying DNA sequence. In general, epigenetic changes pertain to DNA methylation and histone modification, though recently this concept has expanded to include the microRNA regulation of gene expression. Aberrant epigenetic changes are associated with genomic instability and have been implicated in various human diseases. Recent advances in biology and medicine have introduced new technologies to study the genetics/epigenetic mechanisms of the ocular diseases. Knowledge and understanding of these conditions have led to the development of animal models and promising therapies.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the genetic/epigenetic modulation of ocular diseases and to develop strategies to treat these conditions. Potential topics include, but are not limited to:

  • Genetic epidemiological studies on single nucleotide polymorphisms, copy-number variation, epigenetic markers, and circulating microRNA with ocular diseases
  • Functional genomics of candidate genes in ocular diseases
  • Compound screening and clinical trials based on the modulation of disease genes and epigenetic status in ocular diseases

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jop/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jop/epig/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 980608
  • - Editorial

Genetic/Epigenetic Modulation, Ocular Diseases, and Therapeutic Prospective

Jingsheng Tuo | Lai Wei | Nan Hu
  • Special Issue
  • - Volume 2013
  • - Article ID 453934
  • - Research Article

Systems Biology Profiling of AMD on the Basis of Gene Expression

Mones S. Abu-Asab | Jose Salazar | ... | Chi-Chao Chan
  • Special Issue
  • - Volume 2013
  • - Article ID 354798
  • - Research Article

RNA Interference Targeting Connective Tissue Growth Factor Inhibits the Transforming Growth Factor-β2 Induced Proliferation in Human Tenon Capsule Fibroblasts

Jiaona Jing | Ping Li | ... | Huaijin Guan
  • Special Issue
  • - Volume 2013
  • - Article ID 641596
  • - Research Article

An Extensive Replication Study on Three New Susceptibility Loci of Primary Angle Closure Glaucoma in Han Chinese: Jiangsu Eye Study

Haihong Shi | Rongrong Zhu | ... | Huaijin Guan
  • Special Issue
  • - Volume 2013
  • - Article ID 869101
  • - Research Article

RNA Interference Targeting Snail Inhibits the Transforming Growth Factor β2-Induced Epithelial-Mesenchymal Transition in Human Lens Epithelial Cells

Ping Li | Jiaona Jing | ... | Huaijin Guan
  • Special Issue
  • - Volume 2013
  • - Article ID 925267
  • - Review Article

Vascular Adhesion Protein 1 in the Eye

Wenting Luo | Fang Xie | ... | Dawei Sun
Journal of Ophthalmology
 Journal metrics
Acceptance rate37%
Submission to final decision92 days
Acceptance to publication35 days
CiteScore1.780
Impact Factor1.580
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