Journal of Osteoporosis / 2010 / Article / Tab 2

Research Article

A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity

Table 2

Ex vivo microcomputed tomography measures of bone microarchitectural changes in treated mice.

μCT parameters (units) Treatments (n=6/group)
SHMOVXS + VO + GSVGPooled SEMP-value

L5 Vertebral body: trabecular
BV/TV, (%)18.4a12.4c15.1ab14.5bc15.7b0.6<0.0001
BV, (mm3)0.472a0.354b0.394ab0.396ab0.426ab0.019<0.005
Tb.N, (mm-1)3.32a2.77b2.94ab2.76b2.97ab0.116<0.05
Tb.Th, (μm)55a47b55a56a55a1<0.0001
Tb.Sp, (μm)30536734236734116NS
Distal femur: trabecular
BV/TV, (%)2.622.052.391.902.000.08NS
BV, (mm3)0.0660.0570.0620.460.530.01NS
Tb.N, (mm-1)2.211.942.011.912.070.20NS
Tb.Th, (μm)41424443402NS
Tb.Sp, (μm)44652250052448322NS
Midshaft femur: cortical
Area (mm2)0.838a0.770b0.829ab0.806ab0.837a0.014<0.05
Ct.Th, (μm)200a176b194a192a196a0.003<0.001
BV (mm3)0.242a0.222b0.239a0.231ab0.241a0.004<0.05

Data represent the group means. P-values are for one-way ANOVA tests. Different letters indicate means that are statistically different based on Tukey-Kramer post hoc test.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.