TY - JOUR A2 - Engelke, Klaus AU - Craig, Zelieann R. AU - Marion, Samuel L. AU - Funk, Janet L. AU - Bouxsein, Mary L. AU - Hoyer, Patricia B. PY - 2010 DA - 2010/06/29 TI - Retaining Residual Ovarian Tissue following Ovarian Failure Has Limited Influence on Bone Loss in Aged Mice SP - 157323 VL - 2010 AB - Previous work showed that retaining residual ovarian tissue protects young mice from accelerated bone loss following ovarian failure. The present study was designed to determine whether this protection is also present in aged animals. Aged (9–12 months) C57BL/6Hsd female mice were divided into: CON (vehicle), VCD (160 mg/kg; 15d), or OVX (ovariectomized). Lumbar BMD was monitored by DXA and μCT used to assess vertebral microarchitecture. BMD was not different between VCD and CON at any time point but was lower (P<.05) than baseline, starting 1 month after ovarian failure in VCD and OVX mice. Following μCT analysis there were no differences between CON and VCD, but OVX mice had lower bone volume fraction, trabecular thickness, and a trend for decreased connectivity density. These findings provide evidence that retention of residual ovarian tissue may protect aged follicle-depleted mice from accelerated bone loss to a lesser extent than that observed in young mice. SN - 2090-8059 UR - https://doi.org/10.4061/2010/157323 DO - 10.4061/2010/157323 JF - Journal of Osteoporosis PB - SAGE-Hindawi Access to Research KW - ER -