Scientific Basis for the Potential Use of Melatonin in Bone Diseases: Osteoporosis and Adolescent Idiopathic Scoliosis

Figure 3

Summary of the main experimental approaches carried out in humans to clarify the role of melatonin on the AIS. Left, (doted rectangle), studies of changes in melatonin production. Yellow labels are the screening of polymorphisms in genes related with pineal function. White labels identify studies of possible changes in melatonin metabolism or response of target tissues. As in Figure 2, effective (green lines) and noneffective (red lines) results are indicated. Modified from Moreau et al. [73].