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Journal of Osteoporosis
Volume 2011, Article ID 108324, 4 pages
http://dx.doi.org/10.4061/2011/108324
Research Article

Age-Related Changes in Bone Remodelling and Structure in Men: Histomorphometric Studies

Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

Received 13 April 2011; Accepted 22 August 2011

Academic Editor: Pawel Szulc

Copyright © 2011 Juliet Compston. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Histomorphometric studies of the age-related changes in bone remodelling and structure in men are relatively sparse and mainly limited to the iliac crest. The available data indicate that loss of trabecular bone is predominantly due to decreased formation at the level of individual bone remodelling units and that an increase in remodelling rate does not play a major role. The main structural consequence of the changes in bone remodelling is trabecular thinning. In cortical bone, an age-related reduction in cortical width and increase in porosity have been demonstrated at several skeletal sites. However, the alterations in bone remodelling responsible for these changes remain to be established.