Research Article

Lack of Association of Bone Morphogenetic Protein 2 Gene Haplotypes with Bone Mineral Density, Bone Loss, or Risk of Fractures in Men

Table 3

Basic haplotypes of SNP1 and SNP3 at BMP2 gene in men with osteoporosis and controls.

HaplotypeCases no., freq.Control no., freq.Odds ratioChi value

T-A0.3440.4310.69 (0.46–1.04)3.160.07
T-T0.6510.5651.43 (0.96–2.15)3.090.08
G-A0.000.0040.8090.36
G-T0.0050.00019.01 (19.01–65938)*0.9840.321

D′ prime is 0.989 ( value = 0.0264) suggesting that there is a significant linkage disequilibrium between SNP1 and SNP3 but caution is warranted as numbers are small.
*This range is due to the small numbers involved.