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Journal of Osteoporosis
Volume 2011, Article ID 293808, 6 pages
Review Article

A Review on Current Osteoporosis Research: With Special Focus on Disuse Bone Loss

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong

Received 14 March 2011; Revised 26 June 2011; Accepted 29 June 2011

Academic Editor: Merry Jo Oursler

Copyright © 2011 Roy Yuen-chi Lau and Xia Guo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Osteoporosis is a multifactorial skeletal disorder characterized by decreased bone mass and deteriorated microarchitecture that lead to increased risk of fracture. The disuse osteoporosis refers to bone mass decrements under conditions of decreased mechanical loading, including decreased ground force reaction, muscular contraction, and microgravity-related bone loss in astronauts after space flights. Although there are many effective treatments available for primary osteoporosis, there is a lack of effective treatments for disuse osteoporosis. This is because that the aetiology, pathophysiology, and resultant pathology of disuse osteoporosis differ from those of primary osteoporosis. The objective of this paper is to examine the unique pathology and underlying pathophysiology of disuse osteoporosis.