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Journal of Osteoporosis
Volume 2011, Article ID 536735, 14 pages
http://dx.doi.org/10.4061/2011/536735
Review Article

Similarities in Acquired Factors Related to Postmenopausal Osteoporosis and Sarcopenia

1Department of Orthopedics, Traumatology and Hand Surgery, Kuopio University Hospital, 70211 Kuopio, Finland
2Bone and Cartilage Research Unit (BCRU), University of Eastern Finland, 70211 Kuopio, Finland

Received 27 April 2011; Revised 29 June 2011; Accepted 1 July 2011

Academic Editor: Jun Iwamoto

Copyright © 2011 Joonas Sirola and Heikki Kröger. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. The World Health Report, “Making a difference,” 1999, http://www.who.int/whr/1999/en/index.html.
  2. A. Oksuzyan, K. Juel, J. W. Vaupel, and K. Christensen, “Men: good health and high mortality. Sex differences in health and aging,” Aging Clinical and Experimental Research, vol. 20, no. 2, pp. 91–102, 2008. View at Google Scholar · View at Scopus
  3. A. Case and C. Paxson, “Sex differences in morbidity and mortality,” Demography, vol. 42, no. 2, pp. 189–214, 2005. View at Google Scholar · View at Scopus
  4. H. G. Burger, G. E. Hale, D. M. Robertson, and L. Dennerstein, “A review of hormonal changes during the menopausal transition: focus on findings from the Melbourne Women's Midlife Health Project,” Human Reproduction Update, vol. 13, no. 6, pp. 559–565, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. L. R. Nelson and S. E. Bulun, “Estrogen production and action,” Journal of the American Academy of Dermatology, vol. 45, no. 3, pp. S116–S124, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. S. R. Cummings and L. J. Melton, “Osteoporosis I: epidemiology and outcomes of osteoporotic fractures,” Lancet, vol. 359, no. 9319, pp. 1761–1767, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Palacios, R. S. Borrego, and A. Forteza, “The importance of preventive health care in post-menopausal women,” Maturitas, vol. 52, no. 1, supplement, pp. S53–S60, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Abellan Van Kan, “Epidemiology and consequences of sarcopenia,” Journal of Nutrition, Health and Aging, vol. 13, no. 8, pp. 708–712, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. L. J. Melton III, E. A. Chrischilles, C. Cooper, A. W. Lane, and B. L. Riggs, “Perspective: how many women have osteoporosis?” Journal of Bone and Mineral Research, vol. 7, no. 9, pp. 1005–1010, 1992. View at Google Scholar · View at Scopus
  10. I. H. Rosenberg and R. Roubenoff, “Stalking sarcopenia,” Annals of Internal Medicine, vol. 123, no. 9, pp. 727–728, 1995. View at Google Scholar · View at Scopus
  11. R. N. Baumgartner, K. M. Koehler, D. Gallagher et al., “Epidemiology of sarcopenia among the elderly in New Mexico,” American Journal of Epidemiology, vol. 147, no. 8, pp. 755–763, 1998. View at Google Scholar · View at Scopus
  12. I. Janssen, R. N. Baumgartner, R. Ross, I. H. Rosenberg, and R. Roubenoff, “Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women,” American Journal of Epidemiology, vol. 159, no. 4, pp. 413–421, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. L. J. Melton III, S. Khosla, C. S. Crowson, M. K. O'Connor, W. M. O'Fallon, and B. L. Riggs, “Epidemiology of sarcopenia,” Journal of the American Geriatrics Society, vol. 48, no. 6, pp. 625–630, 2000. View at Google Scholar · View at Scopus
  14. I. Janssen, S. B. Heymsfield, and R. Ross, “Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability,” Journal of the American Geriatrics Society, vol. 50, no. 5, pp. 889–896, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Sirola, M. Tuppurainen, T. Rikkonen, R. Honkanen, H. Koivumaa-Honkanen, and H. Kröger, “Correlates and predictors of self-rated health and ambulatory status among elderly women—cross-sectional and 10 years population-based cohort study,” Maturitas, vol. 65, no. 3, pp. 244–252, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. I. Janssen, D. S. Shepard, P. T. Katzmarzyk, and R. Roubenoff, “The healthcare costs of sarcopenia in the United States,” Journal of the American Geriatrics Society, vol. 52, no. 1, pp. 80–85, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. N. F. Ray, J. K. Chan, M. Thamer, and L. J. Melton, “Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995. Report from the National Osteoporosis Foundation,” Journal of Bone and Mineral Research, vol. 12, no. 1, pp. 24–35, 1997. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Dennison, Z. Cole, and C. Cooper, “Diagnosis and epidemiology of osteoporosis,” Current Opinion in Rheumatology, vol. 17, no. 4, pp. 456–461, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. S. R. Cummings and L. J. Melton, “Epidemiology and outcomes of osteoporotic fractures,” Lancet, vol. 359, no. 9319, pp. 1761–1767, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. A. J. Cruz-Jentoft, J. P. Baeyens, J. M. Bauer et al., “Sarcopenia: European consensus on definition and diagnosis Report of the European Working Group on Sarcopenia in older people,” Age and Ageing, vol. 39, pp. 412–423, 2010. View at Google Scholar
  21. R. N. Baumgartner and D. L. Waters, “Sarcopenia and sarcopenic obesity,” in Principles and Practice of Geriatric Meidcine, M. S. J. Pathy, Ed., pp. 909–933, John Wiley and Sons, London, UK, 2006. View at Google Scholar
  22. T. Lang, T. Steeper, P. Cawthon, K. Baldwin, D. R. Taafe, and T. B. Harris, “Sarcopenia: etiology, clinical consequences, intervention and assessement,” Osteoporosis International, vol. 21, pp. 543–559, 2010. View at Google Scholar
  23. B. H. Goodpaster, S. W. Park, T. B. Harris et al., “The loss of skeletal muscle strength, mass, and quality in older adults. The Health, Aging and Body Composition Study,” Journal of Gerontology Series A, vol. 61, no. 10, pp. 1059–1064, 2006. View at Google Scholar · View at Scopus
  24. T. J. Doherty, “Invited review: aging and sarcpenia,” Journal of Applied Physiology, vol. 95, pp. 140–145, 2003. View at Google Scholar
  25. B. C. Clark and T. M. Manini, “Sarcopenia dynapenia,” Journals of Gerontology Series A, vol. 63, no. 8, pp. 829–834, 2008. View at Google Scholar · View at Scopus
  26. M. J. Delmonico, T. B. Harris, J. S. Lee et al., “Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women,” Journal of the American Geriatrics Society, vol. 55, no. 5, pp. 769–774, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Rolland, S. Czerwinski, G. A. Van Kan et al., “Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives,” Journal of Nutrition, Health and Aging, vol. 12, no. 7, pp. 433–450, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. I. Janssen, S. B. Heymsfield, R. N. Baumgartner, and R. Ross, “Estimation of skeletal muscle mass by bioelectrical impedance analysis,” Journal of Applied Physiology, vol. 89, no. 2, pp. 465–471, 2000. View at Google Scholar · View at Scopus
  29. U. G. Kyle, L. Genton, D. O. Slosman, and C. Pichard, “Fat-free and fat mass percentiles in 5225 healthy subjects aged 15 to 98 years,” Nutrition, vol. 17, no. 7-8, pp. 534–541, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Roubenoff, R. N. Baumgartner, T. B. Harris et al., “Application of bioelectrical impedance analysis to elderly populations,” Journals of Gerontology Series A, vol. 52, no. 3, pp. M129–M136, 1997. View at Google Scholar · View at Scopus
  31. U. G. Kyle, L. Genton, L. Karsegard, D. O. Slosman, and C. Pichard, “Single prediction equation for bioelectrical impedance analysis in adults aged 20–94 years,” Nutrition, vol. 17, no. 3, pp. 248–253, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Y. Chien, T. Y. Huang, and Y. T. Wu, “Prevalence of sarcopenia estimated using a bioelectrical impedance analysis prediction equation in community-dwelling elderly people in Taiwan,” Journal of the American Geriatrics Society, vol. 56, no. 9, pp. 1710–1715, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Visser, B. H. Goodpaster, S. B. Kritchevsky et al., “Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons,” Journals of Gerontology Series A, vol. 60, no. 3, pp. 324–333, 2005. View at Google Scholar · View at Scopus
  34. Y. Rolland, V. Lauwers-Cances, M. Cournot et al., “Sarcopenia, calf circumference, and physical function of elderly women: a cross-sectional study,” Journal of the American Geriatrics Society, vol. 51, no. 8, pp. 1120–1124, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Sirola, T. Rikkonen, H. Kröger et al., “Factors related to postmenopausal muscle performance: a cross-sectional population-based study,” European Journal of Applied Physiology, vol. 93, no. 1-2, pp. 102–107, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Al Snih, K. S. Markides, K. J. Ottenbacher, and M. A. Raji, “Hand grip strength and incident ADL disability in elderly Mexican Americans over a seven-year period,” Aging Clinical and Experimental Research, vol. 16, no. 6, pp. 481–486, 2004. View at Google Scholar · View at Scopus
  37. T. Rantanen, S. Volpato, L. Ferrucci, E. Heikkinen, L. P. Fried, and J. M. Guralnik, “Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism,” Journal of the American Geriatrics Society, vol. 51, no. 5, pp. 636–641, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Brown, D. R. Sinacore, E. F. Binder, and W. M. Kohrt, “Physical and performance measures for the identification of mild to moderate frailty,” Journals of Gerontology Series A, vol. 55, no. 6, pp. M350–M355, 2000. View at Google Scholar · View at Scopus
  39. D. Callahan, E. Phillips, R. Carabello, W. R. Frontera, and R. A. Fielding, “Assessment of lower extremity muscle power in functionally-limited elders,” Aging Clinical and Experimental Research, vol. 19, no. 3, pp. 194–199, 2007. View at Google Scholar · View at Scopus
  40. J. A. Neder, L. E. Nery, G. T. Shinzato, M. S. Andrade, C. Peres, and A. C. Silva, “Reference values for concentric knee isokinetic strength and power in nonathletic men and women from 20 to 80 years old,” Journal of Orthopaedic and Sports Physical Therapy, vol. 29, no. 2, pp. 116–126, 1999. View at Google Scholar · View at Scopus
  41. B. H. Goodpaster, C. L. Carlson, M. Visser et al., “Attenuation of skeletal muscle and strength in the elderly: the health ABC study,” Journal of Applied Physiology, vol. 90, no. 6, pp. 2157–2165, 2001. View at Google Scholar · View at Scopus
  42. A. B. Newman, C. L. Haggerty, B. Goodpaster et al., “Strength and muscle quality in a well-functioning cohort of older adults. The Health, Aging and Body Composition Study,” Journal of the American Geriatrics Society, vol. 51, no. 3, pp. 323–330, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. W. J. Evans, S. Bhasin, E. Cress et al., “Functional outcomes for clinical trials in frail older persons: time to be moving,” Journals of Gerontology Series A, vol. 63, no. 2, pp. 160–164, 2008. View at Google Scholar
  44. J. M. Guralnik, E. M. Simonsick, L. Ferrucci et al., “A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission,” Journals of Gerontology, vol. 49, no. 2, pp. M85–M94, 1994. View at Google Scholar · View at Scopus
  45. S. Mathias, U. S. L. Nayak, and B. Isaacs, “Balance in elderly patients: the “get-up and go” test,” Archives of Physical Medicine and Rehabilitation, vol. 67, no. 6, pp. 387–389, 1986. View at Google Scholar · View at Scopus
  46. J. F. Bean, D. K. Kiely, S. LaRose, J. Alian, and W. R. Frontera, “Is stair climb power a clinically relevant measure of leg power impairments in at-risk older adults?” Archives of Physical Medicine and Rehabilitation, vol. 88, no. 5, pp. 604–609, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. NIH, “Osteoporosis. NIH consensus development conference consensus statement,” US Department of Health and Human Services, National Institutes of Health, vol. 5, no. 3, pp. 1–6, 1984. View at Google Scholar
  48. S. R. Cummings, D. M. Black, M. C. Nevitt et al., “Bone density at various sites for prediction of hip fractures,” Lancet, vol. 341, no. 8837, pp. 72–75, 1993. View at Publisher · View at Google Scholar · View at Scopus
  49. H. Kröger, J. Huopio, R. Honkanen et al., “Prediction of fracture risk using axial bone mineral density in a perimenopausal population: a prospective study,” Journal of Bone and Mineral Research, vol. 10, no. 2, pp. 302–306, 1995. View at Google Scholar · View at Scopus
  50. R. Honkanen, H. Kröger, M. Tuppurainen, E. Alhava, and S. Saarikoski, “Fractures and low axial bone density in perimenopausal women,” Journal of Clinical Epidemiology, vol. 48, no. 7, pp. 881–888, 1995. View at Publisher · View at Google Scholar · View at Scopus
  51. J. Huopio, H. Kröger, R. Honkanen, S. Saarikoski, and E. Alhava, “Risk factors for perimenopausal fractures: a prospective study,” Osteoporosis International, vol. 11, no. 3, pp. 219–227, 2000. View at Publisher · View at Google Scholar · View at Scopus
  52. B. J. Riis, M. A. Hansen, A. M. Jensen, K. Overgaard, and C. Christiansen, “Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture: a 15-year follow-up study,” Bone, vol. 19, no. 1, pp. 9–12, 1996. View at Publisher · View at Google Scholar · View at Scopus
  53. M. A. Hansen, K. Overgaard, B. J. Riis, and C. Christiansen, “Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study,” British Medical Journal, vol. 303, no. 6808, pp. 961–964, 1991. View at Google Scholar · View at Scopus
  54. K. E. Ensrud, L. Palermo, D. M. Black et al., “Hip and calcaneal bone loss increase with advancing age: longitudinal results from the study of osteoporotic fractures,” Journal of Bone and Mineral Research, vol. 10, no. 11, pp. 1778–1787, 1995. View at Google Scholar · View at Scopus
  55. “Osteoporosis: review of the evidence for prevention, diagnosis and treatment and costeffectiveness analysis (1998) Status report developed by the National Osteoporosis Foundation,” Osteoporosis International, vol. 8, supplement 4, 1998.
  56. J. A. Kanis, O. Johnell, A. Oden, H. Johansson, and E. McCloskey, “FRAX and the assessment of fracture probability in men and women from the UK,” Osteoporosis International, vol. 19, no. 4, pp. 385–397, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. S. R. Cummings, M. C. Nevitt, W. S. Browner et al., “Risk factors for hip fracture in white women,” New England Journal of Medicine, vol. 332, no. 12, pp. 767–773, 1995. View at Publisher · View at Google Scholar
  58. “NIH Consensus Developement Palnel on Osteoporosis Prevention,” Journal of the American Medical Association, vol. 14, no. 285, pp. 785–795, 2001.
  59. D. Karasik and D. P. Kiel, “Genetics of the musculoskeletal system: a pleiotropic approach,” Journal of Bone and Mineral Research, vol. 23, no. 6, pp. 788–802, 2008. View at Publisher · View at Google Scholar · View at Scopus
  60. T. Douchi, T. Oki, S. Nakamura, H. Ijuin, S. Yamamoto, and Y. Nagata, “The effect of body composition on bone density in pre- and postmenopausal women,” Maturitas, vol. 27, no. 1, pp. 55–60, 1997. View at Publisher · View at Google Scholar · View at Scopus
  61. M. Visser, D. P. Kiel, J. Lagois et al., “Muscle mass and fat mass in relation to bone mireal density in very old men and women. The Framingham Heart Study,” Applied Radiation and Isotopes, vol. 49, pp. 745–747, 1998. View at Google Scholar
  62. H. Blain, A. Vuillemin, A. Teissier, B. Hanesse, F. Guillemin, and C. Jeandel, “Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over,” Gerontology, vol. 47, no. 4, pp. 207–212, 2001. View at Publisher · View at Google Scholar · View at Scopus
  63. M. C. Walsh, G. R. Hunter, and M. B. Livingstone, “Sarcopenia in premenopausal and postmenopausal women with osteopenia, osteoporosis and normal bone mineral density,” Osteoporosis International, vol. 17, no. 1, pp. 61–67, 2006. View at Publisher · View at Google Scholar · View at Scopus
  64. S. Gillette-Guyonnet, F. Nourhashemi, S. Lauque, H. Grandjean, and B. Vellas, “Body composition and osteoporosis in elderly women,” Gerontology, vol. 46, no. 4, pp. 189–193, 2000. View at Google Scholar · View at Scopus
  65. H. M. Frost, “Bone “mass” and the “mechanostat”: a proposal,” Anatomical Record, vol. 219, no. 1, pp. 1–9, 1987. View at Google Scholar · View at Scopus
  66. O. M. Pearson and D. E. Lieberman, “The aging of Wolff's “law”: ontogeny and responses to mechanical loading in cortical bone,” American Journal of Physical Anthropology, vol. 39, pp. 63–99, 2004. View at Google Scholar · View at Scopus
  67. T. Matsuoka, P. E. Ahlberg, N. Kessaris et al., “Neural crest origins of the neck and shoulder,” Nature, vol. 436, no. 7049, pp. 347–355, 2005. View at Publisher · View at Google Scholar · View at Scopus
  68. S. E. Churchill, “Particulate versus integrated evolution of the upper body in late pleistocene humans: a test of two models,” American Journal of Physical Anthropology, vol. 100, no. 4, pp. 559–583, 1996. View at Publisher · View at Google Scholar · View at Scopus
  69. D. Karasik and D. P. Kiel, “Evidence for pleiotropic factors in genetics of the musculoskeletal system,” Bone, vol. 46, no. 5, pp. 1226–1237, 2010. View at Publisher · View at Google Scholar · View at Scopus
  70. V. Gilsanz, T. A. L. Wren, M. Sanchez, F. Dorey, S. Judex, and C. Rubin, “Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD,” Journal of Bone and Mineral Research, vol. 21, no. 9, pp. 1464–1474, 2006. View at Publisher · View at Google Scholar · View at Scopus
  71. F. Lauretani, S. Bandinelli, B. Bartali et al., “Axonal degeneration affects muscle density in older men and women,” Neurobiology of Aging, vol. 27, no. 8, pp. 1145–1154, 2006. View at Publisher · View at Google Scholar · View at Scopus
  72. A. M. Qureshi, F. E. A. McGuigan, D. G. Seymour, J. D. Hutchison, D. M. Reid, and S. H. Ralston, “Association between COLIA1 Sp1 alleles and femoral neck geometry,” Calcified Tissue International, vol. 69, no. 2, pp. 67–72, 2001. View at Publisher · View at Google Scholar · View at Scopus
  73. F. Rivadeneira, J. J. Houwing-Duistermaat, T. J. Beck et al., “The influence of an insulin-like growth factor I gene promoter polymorphism on hip bone geometry and the risk of nonvertebral fracture in the elderly. The Rotterdam study,” Journal of Bone and Mineral Research, vol. 19, no. 8, pp. 1280–1290, 2004. View at Publisher · View at Google Scholar · View at Scopus
  74. J. B. J. Van Meurs, F. Rivadeneira, M. Jhamai et al., “Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men,” Journal of Bone and Mineral Research, vol. 21, no. 1, pp. 141–150, 2006. View at Publisher · View at Google Scholar · View at Scopus
  75. M. J. Khoury, L. L. McCabe, and E. R. B. McCabe, “Population screening in the age of genomic medicine,” New England Journal of Medicine, vol. 348, no. 1, pp. 50–58, 2003. View at Publisher · View at Google Scholar · View at Scopus
  76. K. Tiainen, S. Sipilä, M. Alén et al., “Shared genetic and environmental effects on strength and power in older female twins,” Medicine and Science in Sports and Exercise, vol. 37, no. 1, pp. 72–78, 2005. View at Publisher · View at Google Scholar
  77. K. M. Tiainen, M. Perola, V. M. Kovanen et al., “Genetics of maximal walking speed and skeletal muscle characteristics in older women,” Twin Research and Human Genetics, vol. 11, no. 3, pp. 321–334, 2008. View at Publisher · View at Google Scholar
  78. H. Xu, J. R. Long, Y. J. Yang, F. Y. Deng, and H. W. Deng, “Genetic determination and correlation of body weight and body mass index (BMI) and cross-sectional geometric parameters of the femoral neck,” Osteoporosis International, vol. 17, no. 11, pp. 1602–1607, 2006. View at Publisher · View at Google Scholar · View at Scopus
  79. E. Seeman, J. L. Hopper, N. R. Young, C. Formica, P. Goss, and C. Tsalamandris, “Do genetic factors explain associations between muscle strength, lean mass, and bone density? A twin study,” American Journal of Physiology, vol. 270, no. 2, pp. E320–E327, 1996. View at Google Scholar · View at Scopus
  80. T. M. Mikkola, S. Sipilä, T. Rantanen et al., “Muscle cross-sectional area and structural bone strength share genetic and environmental effects in older women,” Journal of Bone and Mineral Research, vol. 24, no. 2, pp. 338–345, 2009. View at Publisher · View at Google Scholar · View at Scopus
  81. L. Larsson, G. Grimby, and J. Karlsson, “Muscle strength and speed of movement in relation to age and muscle morphology,” Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, vol. 46, no. 3, pp. 451–456, 1979. View at Google Scholar · View at Scopus
  82. G. Grimby and B. Saltin, “Mini-review: the aging muscle,” Clinical Physiology, vol. 3, no. 3, pp. 209–218, 1983. View at Google Scholar · View at Scopus
  83. V. A. Hughes, W. R. Frontera, R. Roubenoff, W. J. Evans, and M. A. Fiatarone Singh, “Longitudinal changes in body composition in older men and women: role of body weight change and physical activity,” American Journal of Clinical Nutrition, vol. 76, no. 2, pp. 473–481, 2002. View at Google Scholar · View at Scopus
  84. A. A. Vandervoort, “Aging of the human neuromuscular system,” Muscle and Nerve, vol. 25, no. 1, pp. 17–25, 2002. View at Publisher · View at Google Scholar · View at Scopus
  85. R. Roubenoff and V. A. Hughes, “Sarcopenia: current concepts,” Journals of Gerontology Series A, vol. 55, no. 12, pp. M716–M724, 2000. View at Google Scholar · View at Scopus
  86. J. E. Morley et al., “Sarcopenia,” Journal of Laboratory and Clinical Medicine, vol. 137, pp. 231–243, 2001. View at Google Scholar
  87. W. Evans, “Functional and metabolic consequences of sarcopenia,” Journal of Nutrition, vol. 127, no. 5, pp. 998S–1003S, 1997. View at Google Scholar · View at Scopus
  88. M. M. Samson, I. B. A. E. Meeuwsen, A. Crowe, J. A. G. Dessens, S. A. Duursma, and H. J. J. Verhaar, “Relationships between physical performance measures, age, height and body weight in healthy adults,” Age and Ageing, vol. 29, no. 3, pp. 235–242, 2000. View at Google Scholar · View at Scopus
  89. S. K. Phillips, K. M. Rook, N. C. Siddle, S. A. Bruce, and R. C. Woledge, “Muscle weakness in women occurs at an earlier age than in men, but strength is preserved by hormone replacement therapy,” Clinical Science, vol. 84, no. 1, pp. 95–98, 1993. View at Google Scholar · View at Scopus
  90. T. Douchi, S. Yamamoto, S. Nakamura et al., “The effect of menopause on regional and total body lean mass,” Maturitas, vol. 29, no. 3, pp. 247–252, 1998. View at Publisher · View at Google Scholar · View at Scopus
  91. V. Messier, R. Rabasa-Lhoret, S. Barbat-Artigas, B. Elisha, A. D. Karelis, and M. Aubertin-Leheurde, “Menopause and sarcopenia: apotential role for sex hormones,” Maturitas, vol. 68, pp. 331–336, 2011. View at Google Scholar
  92. M. Iannuzzi-Sucich, K. M. Prestwood, and A. M. Kenny, “Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women,” Journals of Gerontology Series A, vol. 57, no. 12, pp. M772–M777, 2002. View at Google Scholar · View at Scopus
  93. M. Brown, “Skeletal muscle and bone: effect of sex steroids and aging,” American Journal of Physiology, vol. 32, no. 2, pp. 120–126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  94. R. Roubenoff, “Catabolism of aging: is it an inflammatory process?” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 6, no. 3, pp. 295–299, 2003. View at Publisher · View at Google Scholar · View at Scopus
  95. J. P. Greeves, N. T. Cable, T. Reilly, and C. Kingsland, “Changes in muscle strength in women following the menopause: a longitudinal assessment of the efficacy of hormone replacement therapy,” Clinical Science, vol. 97, no. 1, pp. 79–84, 1999. View at Publisher · View at Google Scholar · View at Scopus
  96. S. Sipilä, D. R. Taaffe, S. Cheng, J. Puolakka, J. Toivanen, and H. Suominen, “Effects of hormone replacement therapy and high-impact physical exercise on skeletal muscle in post-menopausal women: a randomized placebo-controlled study,” Clinical Science, vol. 101, no. 2, pp. 147–157, 2001. View at Publisher · View at Google Scholar · View at Scopus
  97. M. B. Sørensen, A. M. Rosenfalck, L. Højgaard, and B. Ottesen, “Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy,” Obesity Research, vol. 9, no. 10, pp. 622–626, 2001. View at Google Scholar · View at Scopus
  98. Z. Chen, T. Bassford, S. B. Green et al., “Postmenopausal hormone therapy and body composition - A substudy of the estrogen plus progestin trial of the Women's Health Initiative,” American Journal of Clinical Nutrition, vol. 82, no. 3, pp. 651–656, 2005. View at Google Scholar · View at Scopus
  99. R. D. Hansen, C. Raja, R. J. Baber, D. Lieberman, and B. J. Allen, “Effects of 20-mg oestradiol implant therapy on bone mineral density, fat distribution and muscle mass in postmenopausal women,” Acta Diabetologica, vol. 40, no. 1, pp. S191–S195, 2003. View at Publisher · View at Google Scholar · View at Scopus
  100. A. M. Kenny, L. Dawson, A. Kleppinger, M. Iannuzzi-Sucich, and J. O. Judge, “Prevalence of sarcopenia and predictors of skeletal muscle mass in nonobese women who are long-term users of estrogen-replacement therapy,” Journals of Gerontology Series A, vol. 58, no. 5, pp. 436–440, 2003. View at Google Scholar
  101. M. J. Ousler, M. Kassem, R. Turner, B. L. Riggs, and T. C. Spelsberg, “Regulation of bone cell function by gonadal steroids,” in Osteoprosis, R. Marcus, D. Feldman, and J. Kelsey, Eds., pp. 237–253, Academic Press, San Diego, Calif, USA, 1996. View at Google Scholar
  102. S. C. Manolagas, “The role of IL-6 type cytokines and their receptors in bone a,” Annals of the New York Academy of Sciences, vol. 840, pp. 194–204, 1998. View at Google Scholar · View at Scopus
  103. B. L. Riggs, S. Khosla, and L. J. Melton III, “Sex steroids and the construction and conservation of the adult skeleton,” Endocrine Reviews, vol. 23, no. 3, pp. 279–302, 2002. View at Publisher · View at Google Scholar · View at Scopus
  104. S. Adami, D. Gatti, F. Bertoldo et al., “The effects of menopause and estrogen replacement therapy on the renal handling of calcium,” Osteoporosis International, vol. 2, no. 4, pp. 180–185, 1992. View at Publisher · View at Google Scholar · View at Scopus
  105. J. M. Pouilles, F. Tremollieres, and C. Ribot, “The effects of menopause on longitudinal bone loss from the spine,” Calcified Tissue International, vol. 52, no. 5, pp. 340–343, 1993. View at Google Scholar · View at Scopus
  106. J. M. Pouilles, F. Tremollieres, and C. Ribot, “Effect of menopause on femoral and vertebral bone loss,” Journal of Bone and Mineral Research, vol. 10, no. 10, pp. 1531–1536, 1995. View at Google Scholar · View at Scopus
  107. M. Tuppurainen, R. Honkanen, H. Kröger, S. Saarikoski, and E. Alhava, “Osteoporosis risk factors, gynaecological history and fractures in perimenopausal women—the results of the baseline postal enquiry of the Kuopio Osteoporosis Risk Factor and Prevention Study,” Maturitas, vol. 17, no. 2, pp. 89–100, 1993. View at Google Scholar · View at Scopus
  108. H. Kröger, M. Tuppurainen, R. Honkanen, E. Alhava, and S. Saarikoski, “Bone mineral density and risk factors for osteoporosis—a population-based study of 1600 perimenopausal women,” Calcified Tissue International, vol. 55, no. 1, pp. 1–7, 1994. View at Publisher · View at Google Scholar · View at Scopus
  109. H. G. Ahlborg, O. Johnell, B. E. Nilsson, S. Jeppsson, G. Rannevik, and M. K. Karlsson, “Bone loss in relation to menopause: a prospective study during 16 years,” Bone, vol. 28, no. 3, pp. 327–331, 2001. View at Publisher · View at Google Scholar · View at Scopus
  110. J. C. Prior, “Perimenopause: the complex endocrinology of the menopausal transition,” Endocrine Reviews, vol. 19, no. 4, pp. 397–428, 1998. View at Google Scholar · View at Scopus
  111. S. Harris and B. Dawson-Hughes, “Rates of change in bone mineral density of the spine, heel, femoral neck and radius in healthy postmenopausal women,” Bone and Mineral, vol. 17, no. 1, pp. 87–95, 1992. View at Publisher · View at Google Scholar · View at Scopus
  112. M. A. Hansen, K. Overgaard, and C. Christiansen, “Spontaneous postmenopausal bone loss in different skeletal areas—followed up for 15 years,” Journal of Bone and Mineral Research, vol. 10, no. 2, pp. 205–210, 1995. View at Google Scholar · View at Scopus
  113. R. Young, H. May, S. Murphy, C. Grey, and J. E. Compston, “Rates of bone loss in peri- and postmenopausal women: a 41 year, prospective, population-based study,” Clinical Science, vol. 91, no. 3, pp. 307–312, 1996. View at Google Scholar · View at Scopus
  114. M. Ito, T. Nakamura, K. Tsurusaki, M. Uetani, and K. Hayashi, “Effects of menopause on age-dependent bone loss in the axial and appendicular skeletons in healthy Japanese women,” Osteoporosis International, vol. 10, no. 5, pp. 377–383, 1999. View at Publisher · View at Google Scholar · View at Scopus
  115. J. A. Pasco, E. Seeman, M. J. Henry, E. N. Merriman, G. C. Nicholson, and M. A. Kotowicz, “The population burden of fractures originates in women with osteopenia, not osteoporosis,” Osteoporosis International, vol. 17, no. 9, pp. 1404–1409, 2006. View at Publisher · View at Google Scholar
  116. R. Lindsay and J. F. Tohme, “Estrogen treatment of patients with established postmenopausal osteoporosis,” Obstetrics and Gynecology, vol. 76, no. 2, pp. 290–295, 1990. View at Google Scholar
  117. J. A. Cauley, D. G. Seeley, K. Ensrud, B. Ettinger, D. Black, and S. R. Cummings, “Estrogen replacement therapy and fractures in older women,” Annals of Internal Medicine, vol. 122, no. 1, pp. 9–16, 1995. View at Google Scholar
  118. D. L. Schneider, E. L. Barrett-Connor, and D. J. Morton, “Timing of postmenopausal estrogen for optimal bone mineral density. The Rancho Bernardo study,” Journal of the American Medical Association, vol. 277, no. 7, pp. 543–547, 1997. View at Google Scholar · View at Scopus
  119. M. H. Komulainen, H. Kröger, M. T. Tuppurainen et al., “HRT and Vit D in prevention of non-vertebral fractures in postmenopausal women; a 5 year randomized trial,” Maturitas, vol. 31, no. 1, pp. 45–54, 1998. View at Publisher · View at Google Scholar · View at Scopus
  120. D. M. Eddy, C. C. Johnston Jr., S. R. Cummings et al., “Osteoporosis: review of the evidence for prevention, diagnosis, and treatment and cost-effectiveness analysis. Status report,” Osteoporosis International, vol. 8, no. supplement 4, pp. S1–S82, 1998. View at Google Scholar
  121. G. Wells, P. Tugwell, B. Shea et al., “V. Meta-analysis of the efficacy of hormone replacement therapy in treating and preventing osteoporosis in postmenopausal women,” Endocrine Reviews, vol. 23, no. 4, pp. 529–539, 2002. View at Publisher · View at Google Scholar
  122. C. R. Russo, M. Ricca, and L. Ferrucci, “True osteoporosis and frailty-related osteopenia: two different clinical entities,” Journal of the American Geriatrics Society, vol. 48, no. 12, pp. 1738–1739, 2000. View at Google Scholar · View at Scopus
  123. S. Maggi, F. Lauretani, L. Ferrucci et al., “The quality of bone: a “magic natural alloy”,” Aging Clinical and Experimental Research, vol. 16, no. 3, pp. 3–9, 2004. View at Google Scholar · View at Scopus
  124. G. L. Jones and A. Sutton, “Quality of life in obese postmenopausal women,” Menopause International, vol. 14, no. 1, pp. 26–32, 2008. View at Publisher · View at Google Scholar · View at Scopus
  125. K. E. Dennis, “Postmenopausal women and the health consequences of obesity,” Journal of Obstetric, Gynecologic, and Neonatal Nursing, vol. 36, no. 5, pp. 511–519, 2007. View at Publisher · View at Google Scholar
  126. C. E. I. Lebrun, Y. T. Van Der Schouw, F. H. De Jong, D. E. Grobbee, and S. W. Lamberts, “Fat mass rather than muscle strength is the major determinant of physical function and disability in postmenopausal women younger than 75 years of age,” Menopause, vol. 13, no. 3, pp. 474–481, 2006. View at Publisher · View at Google Scholar
  127. H. B. Hubert, D. A. Bloch, and J. F. Fries, “Risk factors for physical disability in an aging cohort. The NHANES I Epidemiologic Followup Study,” Journal of Rheumatology, vol. 20, pp. 480–488, 1993. View at Google Scholar
  128. J. W. Davis, P. D. Ross, S. D. Preston, M. C. Nevitt, and R. D. Wasnich, “Strength, physical activity, and body mass index: relationship to performance-based measures and activities of daily living among older Japanese women in Hawaii,” Journal of the American Geriatrics Society, vol. 46, no. 3, pp. 274–279, 1998. View at Google Scholar · View at Scopus
  129. M. Visser, J. Langlois, J. M. Guralnik et al., “High body fatness, but not low fat-free mass, predicts disability in older men and women: the cardiovascular health study,” American Journal of Clinical Nutrition, vol. 68, no. 3, pp. 584–590, 1998. View at Google Scholar · View at Scopus
  130. A. Rissanen, M. Heliovaara, P. Knekt, A. Reunanen, A. Aromaa, and J. Maatela, “Risk of disability and mortality due to overweight in a Finnish population,” British Medical Journal, vol. 301, no. 6756, pp. 835–837, 1990. View at Google Scholar · View at Scopus
  131. N. Duvigneaud, L. Matton, K. Wijndaele et al., “Relationship of obesity with physical activity, aerobic fitness and muscle strength in Flemish adults,” Journal of Sports Medicine and Physical Fitness, vol. 48, no. 2, pp. 201–210, 2008. View at Google Scholar · View at Scopus
  132. M. Cesari, S. B. Kritchevsky, R. N. Baumgartner et al., “Sarcopenia, obesity, and inflammation—results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study,” American Journal of Clinical Nutrition, vol. 82, no. 2, pp. 428–434, 2005. View at Google Scholar · View at Scopus
  133. B. H. Goodpaster, S. Krishnaswami, H. Resnick et al., “Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women,” Diabetes Care, vol. 26, no. 2, pp. 372–379, 2003. View at Publisher · View at Google Scholar · View at Scopus
  134. B. H. Goodpaster, S. Krishnaswami, H. Resnick et al., “Thigh adipose tissue distribution id associated with insuloin resistance in obesity and type 2 diabetes mellitus,” The American Journal of Clinical Nutrition, vol. 71, pp. 885–892, 2000. View at Google Scholar
  135. D. L. Waters, C. R. Qualls, R. I. Dorin et al., “Altered growth hormone, cortical and leptin secretion in healthy elderly persons with sarcopenia and mixed body composition phenotyoes,” Journals of Gerontology Series A, vol. 63, pp. 536–541, 2008. View at Google Scholar
  136. R. N. Baumgartner, “Body composition in healthy aging,” Annals of the New York Academy of Sciences, vol. 904, pp. 437–448, 2000. View at Google Scholar · View at Scopus
  137. M. Zamboni, G. Mazzali, F. Fantin, A. Rossi, and V. Di Francesco, “Sarcopenic obesity: a new category of obesity in the elderly,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 18, no. 5, pp. 388–395, 2008. View at Publisher · View at Google Scholar
  138. E. Zoico, V. Di Francesco, J. M. Guralnik et al., “Physical disability and muscular strength in relation to obesity and different body composition indexes in a sample of healthy elderly women,” International Journal of Obesity, vol. 28, no. 2, pp. 234–241, 2004. View at Google Scholar · View at Scopus
  139. R. N. Baumgartner, S. J. Wayne, D. L. Waters, I. Janssen, D. Gallagher, and J. E. Morley, “Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly,” Obesity Research, vol. 12, no. 12, pp. 1995–2004, 2004. View at Google Scholar
  140. A. B. Newman, J. S. Lee, M. Visser et al., “Weight change and the conservation of lean mass in old age. The Health, Aging and Body Composition Study,” American Journal of Clinical Nutrition, vol. 82, no. 4, pp. 872–878, 2005. View at Google Scholar · View at Scopus
  141. T. N. Frimel, D. R. Sinacore, and D. T. Villareal, “Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults,” Medicine and Science in Sports and Exercise, vol. 40, no. 7, pp. 1213–1219, 2008. View at Publisher · View at Google Scholar · View at Scopus
  142. J. Sirola, T. Rikkonen, M. Tuppurainen, R. Honkanen, J. S. Jurvelin, and H. Kröger, “Maintenance of muscle strength may counteract weight-loss-related postmenopausal bone loss—a population-based approach,” Osteoporosis International, vol. 17, no. 5, pp. 775–782, 2006. View at Publisher · View at Google Scholar · View at Scopus
  143. N. Yoshimura, T. Hashimoto, S. Morioka, K. Sakata, T. Kasamatsu, and C. Cooper, “Determinants of bone loss in a rural Japanese community. The Taiji study,” Osteoporosis International, vol. 8, no. 6, pp. 604–610, 1998. View at Publisher · View at Google Scholar · View at Scopus
  144. T. V. Nguyen, P. N. Sambrook, and J. A. Eisman, “Bone loss, physical activity, and weight change in elderly women: the dubbo osteoporosis epidemiology study,” Journal of Bone and Mineral Research, vol. 13, no. 9, pp. 1458–1467, 1998. View at Publisher · View at Google Scholar · View at Scopus
  145. C. Brot, L. B. Jensen, and O. H. Sørensen, “Bone mass and risk factors for bone loss in perimenopausal Danish women,” Journal of Internal Medicine, vol. 242, no. 6, pp. 505–511, 1997. View at Google Scholar · View at Scopus
  146. C. De Laet, J. A. Kanis, A. Odén et al., “Body mass index as a predictor of fracture risk: a meta-analysis,” Osteoporosis International, vol. 16, no. 11, pp. 1330–1338, 2005. View at Publisher · View at Google Scholar · View at Scopus
  147. J. Sirola, H. Kröger, R. Honkanen et al., “Risk factors associated with peri- and postmenopausal bone loss: does HRT prevent weight loss-related bone loss?” Osteoporosis International, vol. 14, no. 1, pp. 27–33, 2003. View at Publisher · View at Google Scholar · View at Scopus
  148. H. Blain, A. Vuillemin, F. Guillemin et al., “Serum leptin level is a predictor of bone mineral density in postmenopausal women,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 3, pp. 1030–1035, 2002. View at Publisher · View at Google Scholar
  149. M. Yamauchi, T. Sugimoto, T. Yamaguchi et al., “Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women,” Clinical Endocrinology, vol. 55, no. 3, pp. 341–347, 2001. View at Publisher · View at Google Scholar · View at Scopus
  150. M. O. Premaor, L. Pilbrow, C. Tonkin, R. A. Parker, and J. Compston, “Obesity and fractures in postmenopausal women,” Journal of Bone and Mineral Research, vol. 25, no. 2, pp. 292–297, 2010. View at Publisher · View at Google Scholar · View at Scopus
  151. H. H. Bolotin, “A new perspective on the causal influence of soft tissue composition on DXA-measured in vivo bone mineral density,” Journal of Bone and Mineral Research, vol. 13, no. 11, pp. 1739–1746, 1998. View at Publisher · View at Google Scholar · View at Scopus
  152. F. Lauretani, S. Bandinelli, C. R. Russo et al., “Correlates of bone quality in older persons,” Bone, vol. 39, no. 4, pp. 915–921, 2006. View at Publisher · View at Google Scholar · View at Scopus
  153. D. N. Proctor, L. J. Melton, S. Khosla, C. S. Crowson, M. K. O’Connor, and B. L. Riggs, “Relative influence of physical activity, muscle mass and atrength on bone density,” Osteoporosis International, vol. 11, pp. 944–952, 2000. View at Google Scholar
  154. J. Rittweger, G. Beller, J. Ehrig et al., “Bone-muscle strength indices for the human lower leg,” Bone, vol. 27, no. 2, pp. 319–326, 2000. View at Publisher · View at Google Scholar · View at Scopus
  155. H. M. Frost, “Bone's mechanostat: a 2003 update,” Anatomical Record Part A, vol. 275, no. 2, pp. 1081–1101, 2003. View at Google Scholar · View at Scopus
  156. P. Kortebein, A. Ferrando, J. Lombeida, R. Wolfe, and W. J. Evans, “Effect of 10 days of bed rest on skeletal muscle in healthy older adults,” Journal of the American Medical Association, vol. 297, no. 16, pp. 1772–1774, 2007. View at Google Scholar · View at Scopus
  157. J. S. W. Lee, T. W. Auyeung, T. Kwok, E. M. C. Lau, P. C. Leung, and J. Woo, “Associated factors and health impact of sarcopenia in older Chinese men and women: a cross-sectional study,” Gerontology, vol. 53, no. 6, pp. 404–410, 2008. View at Publisher · View at Google Scholar · View at Scopus
  158. M. Sheffield-Moore, C. W. Yeckel, E. Volpi et al., “Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise,” American Journal of Physiology, vol. 287, pp. E513–E522, 2004. View at Publisher · View at Google Scholar
  159. A. R. Coggan, R. J. Spina, D. S. King et al., “Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women,” Journal of Applied Physiology, vol. 72, no. 5, pp. 1780–1786, 1992. View at Google Scholar · View at Scopus
  160. N. Charifi, F. Kadi, L. Féasson, and C. Denis, “Effects of endurance training on satellite cell frequency in skeletal muscle of old men,” Muscle and Nerve, vol. 28, no. 1, pp. 87–92, 2003. View at Publisher · View at Google Scholar · View at Scopus
  161. S. L. Charette, L. McEvoy, G. Pyka et al., “Muscle hypertrophy response to resistance training in older women,” Journal of Applied Physiology, vol. 70, no. 5, pp. 1912–1916, 1991. View at Google Scholar · View at Scopus
  162. D. L. Hasten et al., “Resistence exercise acuteky increases MHC and mioxed muscle protein synthesis rates in 78–84 and 23–32 yr olds,” American Journal of Physiology, vol. 265, pp. E620–E626, 1993. View at Google Scholar
  163. A. C. Jozsi, W. W. Campbell, L. Joseph, S. L. Davey, and W. J. Evans, “Changes in power with resistance training in older and younger men and women,” Journals of Gerontology Series A, vol. 54, no. 11, pp. M591–M596, 1999. View at Google Scholar · View at Scopus
  164. S. Welle, C. Thornton, and M. Statt, “Myofibrillar protein synthesis in young and old human subjects after three months of resistance training,” American Journal of Physiology, vol. 268, no. 3, pp. E422–E427, 1995. View at Google Scholar · View at Scopus
  165. M. A. Fiatarone, E. F. O'Neill, N. D. Ryan et al., “Exercise training and nutritional supplementation for physical frailty in very elderly people,” New England Journal of Medicine, vol. 330, no. 25, pp. 1769–1775, 1994. View at Publisher · View at Google Scholar · View at Scopus
  166. K. E. Yarasheski, J. Pak-Loduca, D. L. Hasten, K. A. Obert, M. B. Brown, and D. R. Sinacore, “Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men ≥ 76 yr old,” American Journal of Physiology, vol. 277, no. 1, pp. E118–E125, 1999. View at Google Scholar · View at Scopus
  167. F. M. Ivey, S. M. Roth, R. E. Ferrell et al., “Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training,” Journals of Gerontology Series A, vol. 55, no. 11, pp. M641–M648, 2000. View at Google Scholar · View at Scopus
  168. M. E. Cress et al., “Exercise: effects of physical functional performance in independent older adults,” Journals of Gerontology Series A, vol. 55, pp. 641–648, 2000. View at Google Scholar
  169. C. A. Raguso, U. Kyle, M. P. Kossovsky et al., “A 3-year longitudinal study on body composition changes in the elderly: role of physical exercise,” Clinical Nutrition, vol. 25, no. 4, pp. 573–580, 2006. View at Publisher · View at Google Scholar · View at Scopus
  170. A. A. Sayer, H. E. Syddall, H. J. Martin, E. M. Dennison, F. H. Anderson, and C. Cooper, “Falls, sarcopenia, and growth in early life: findings from the hertfordshire cohort study,” American Journal of Epidemiology, vol. 164, no. 7, pp. 665–671, 2006. View at Publisher · View at Google Scholar · View at Scopus
  171. A. A. Sayer, H. E. Syddall, H. J. Gilbody, E. M. Dennison, and C. Cooper, “Does sarcopenia originate in early life? Findings from the Hertfordshire Cohort Study,” Journals of Gerontology Series A, vol. 59, no. 9, pp. 930–934, 2004. View at Google Scholar · View at Scopus
  172. S. Kaptoge, N. Dalzell, R. W. Jakes et al., “Hip section modulus, a measure of bending resistance, is more strongly related to reported physical activity than BMD,” Osteoporosis International, vol. 14, no. 11, pp. 941–949, 2003. View at Publisher · View at Google Scholar
  173. C. H. Turner, Y. Takano, and I. Owan, “Aging changes mechanical loading thresholds for bone formation in rats,” Journal of Bone and Mineral Research, vol. 10, no. 10, pp. 1544–1549, 1995. View at Google Scholar · View at Scopus
  174. M. R. Forwood and D. B. Burr, “Physical activity and bone mass: exercises in futility?” Bone and Mineral, vol. 21, no. 2, pp. 89–112, 1993. View at Google Scholar · View at Scopus
  175. B. A. Wallace and R. G. Cumming, “Systematic review onb randomised trials of the effect of exercise on bone mass in pre- and postmenopausal women,” Calcified Tissue International, vol. 67, pp. 10–18, 2000. View at Google Scholar
  176. J. Sirola, T. Rikkonen, M. Tuppurainen, J. S. Jurvelin, and H. Kröger, “Association of grip strength change with menopausal bone loss and related fractures: a population-based follow-up study,” Calcified Tissue International, vol. 78, no. 4, pp. 218–226, 2006. View at Publisher · View at Google Scholar · View at Scopus
  177. J. Sirola, M. Tuppurainen, R. Honkanen, J. S. Jurvelin, and H. Kröger, “Associations between grip strength change and axial postmenopausal bone loss—a 10-year population-based follow-up study,” Osteoporosis International, vol. 16, no. 12, pp. 1841–1848, 2005. View at Publisher · View at Google Scholar · View at Scopus
  178. B. J. Kiratli, “Immobilization osteopenia,” in Osteoporosis, R. Marcus, D. Feldman, and J. Kelsey, Eds., pp. 833–853, Academic Press, San Diego, Calif, USA, 1996. View at Google Scholar
  179. J. Sirola and T. Rikkonen, “Muscle performance after the menopause—review,” Journal of the British Menopause Society, vol. 16, no. 12, pp. 1841–1848, 2005. View at Google Scholar
  180. M. Kärkkäinen, T. Rikkonen, H. Kröger et al., “Physical tests for patient selection for bone mineral density measurements in postmenopausal women,” Bone, vol. 44, no. 4, pp. 660–665, 2009. View at Publisher · View at Google Scholar · View at Scopus
  181. M. Kärkkäinen, T. Rikkonen, H. Kröger et al., “Association between functional capacity tests and fractures: an eight-year prospective population-based cohort study,” Osteoporosis International, vol. 19, no. 8, pp. 1203–1210, 2008. View at Publisher · View at Google Scholar · View at Scopus
  182. D. Bonaiuti, B. Shea, R. Iovine et al., “Exercise for preventing and treating osteoporosis In postmenopausal women (review),” Cochrane Reviews, no. 1, 2009. View at Google Scholar
  183. R. U. Simpson, G. A. Thomas, and A. J. Arnold, “Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle,” Journal of Biological Chemistry, vol. 260, no. 15, pp. 8882–8891, 1985. View at Google Scholar · View at Scopus
  184. G. Mingrone, A. V. Greco, M. Castagneto, and G. Gasbarrini, “A woman who left her wheelchair,” Lancet, vol. 353, no. 9155, p. 806, 1999. View at Publisher · View at Google Scholar · View at Scopus
  185. P. M.F. Campbell and T. J. Allain, “Muscle strength and vitamin D in older people,” Gerontology, vol. 52, no. 6, pp. 335–338, 2006. View at Publisher · View at Google Scholar
  186. K. A. Ward, G. Das, J. L. Berry et al., “Vitamin D status and muscle function in post-menarchal adolescent girls,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 2, pp. 559–563, 2009. View at Publisher · View at Google Scholar
  187. H. A. Bischoff-Ferrari, T. Dietrich, E. J. Orav et al., “Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged ≥60 y,” American Journal of Clinical Nutrition, vol. 80, no. 3, pp. 752–758, 2004. View at Google Scholar · View at Scopus
  188. I. S. Wicherts, N. M. van Schoor, A. J. Boeke et al., “Vitamin D status predicts physical performance and its decline in older persons,” The Journal of Clinical Endocrinology and Metabolism, vol. 92, pp. 2058–2065, 2007. View at Google Scholar
  189. D. Bunout, G. Barrera, L. Leiva et al., “Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects,” Experimental Gerontology, vol. 41, no. 8, pp. 746–752, 2006. View at Publisher · View at Google Scholar
  190. H. A. Bischoff-Ferrari, H. B. Stähelin, W. Dick et al., “Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial,” Journal of Bone and Mineral Research, vol. 18, no. 2, pp. 343–351, 2003. View at Publisher · View at Google Scholar · View at Scopus
  191. M. Pfeifer, B. Begerow, H. W. Minne, K. Suppan, A. Fahrleitner-Pammer, and H. Dobnig, “Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals,” Osteoporosis International, vol. 20, no. 2, pp. 315–322, 2009. View at Publisher · View at Google Scholar
  192. J. K. Dhesi, L. M. Bearne, C. Moniz et al., “Neuromuscular and psychomotor function in elderly subjects who fall and the relationship with vitamin D status,” Journal of Bone and Mineral Research, vol. 17, pp. 891–897, 2002. View at Google Scholar
  193. H. A. Bischoff-Ferrari, M. Conzelmann, H. B. Stähelin et al., “Is fall prevention by vitamin D mediated by a change in postural or dynamic balance?” Osteoporosis International, vol. 17, no. 5, pp. 656–663, 2006. View at Publisher · View at Google Scholar · View at Scopus
  194. R. R. Kalyani, B. Stein, R. Valiyil, R. Manno, J. W. Maynard, and D. C. Crews, “Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis,” Journal of the American Geriatrics Society, vol. 58, no. 7, pp. 1299–1310, 2010. View at Publisher · View at Google Scholar · View at Scopus
  195. M. Visser, D. J. H. Deeg, and P. Lips, “Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (Sarcopenia): the longitudinal aging study Amsterdam,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 12, pp. 5766–5772, 2003. View at Publisher · View at Google Scholar
  196. B. Dawson-Hughes, “Calcium and vitamin D,” in Primer on the Metabolic Bone Diseases and Disorders of Bone Metabolism, pp. 231–233, American Society for Bone and Mineral Research, 2008. View at Google Scholar
  197. H. A. Bischoff-Ferrari, D. P. Kiel, B. Dawson-HIghes et al., “Dietary calcium and serum 25-hydroxyvitamin D status in relation to bone mineral density among U.S. adults,” Journal of Bone and Mineral Research, vol. 24, pp. 935–942, 2009. View at Google Scholar
  198. J. S. Adams, V. Kantorovich, C. Wu, M. Javanbakht, and B. W. Hollis, “Resolution of vitamin D insufficiency in osteopenic patients results in rapid recovery of bone mineral density,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 8, pp. 2729–2730, 1999. View at Google Scholar
  199. P. Garnero, F. Munoz, E. Sornay-Rendu, and P. D. Delmas, “Associations of vitamin D status with bone mineral density, bone turnover, bone loss and fracture risk in healthy postmenopausal women. The OFELY study,” Bone, vol. 40, no. 3, pp. 716–722, 2007. View at Publisher · View at Google Scholar · View at Scopus
  200. L. Cooper, P. B. Clifton-Bligh, M. L. Nery et al., “Vitamin D supplementation and bone mineral density in early postmenopausal women,” American Journal of Clinical Nutrition, vol. 77, no. 5, pp. 1324–1329, 2003. View at Google Scholar · View at Scopus
  201. A. Avenell, W. J. Gillespie, L. D. Gillespie, and D. O'Connell, “Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD000227, 2009. View at Publisher · View at Google Scholar · View at Scopus
  202. M. E. Tinetti, M. Speechley, and S. F. Ginter, “Risk factors for falls among elderly persons living in the community,” New England Journal of Medicine, vol. 319, no. 26, pp. 1701–1707, 1988. View at Google Scholar · View at Scopus
  203. M. C. Nevitt, S. R. Cummings, S. Kidd, and D. Black, “Risk factors for recurrent nonsyncopal falls. A prospective study,” Journal of the American Medical Association, vol. 261, no. 18, pp. 2663–2668, 1989. View at Google Scholar
  204. V. S. Stel, J. H. Smit, S. M. F. Pluijm, and P. Lips, “Consequences of falling in older men and women and risk factors for health service use and functional decline,” Age and Ageing, vol. 33, no. 1, pp. 58–65, 2004. View at Publisher · View at Google Scholar · View at Scopus
  205. M. T. Vogt, J. A. Cauley, M. M. Tomaino, K. Stone, J. R. Williams, and J. H. Herndon, “Distal radius fractures in older women: a 10-year follow-up study of descriptive characteristics and risk factors. The study of osteoporotic fractures,” Journal of the American Geriatrics Society, vol. 50, no. 1, pp. 97–103, 2002. View at Publisher · View at Google Scholar · View at Scopus
  206. B. Kristiansen, G. Barfod, and J. Bredesen, “Epidemiology of proximal humeral fractures,” Acta Orthopaedica Scandinavica, vol. 58, no. 1, pp. 75–77, 1987. View at Google Scholar
  207. W. C. Hayes, E. R. Myers, J. N. Morris, T. N. Gerhart, H. S. Yett, and L. A. Lipsitz, “Impact near the hip dominates fracture risk in elderly nursing home residents who fall,” Calcified Tissue International, vol. 52, no. 3, pp. 192–198, 1993. View at Google Scholar · View at Scopus
  208. S. R. Lord and J. A. Ward, “Age-associated differences in sensori-motor function and balance in community dwelling women,” Age and Ageing, vol. 23, no. 6, pp. 452–460, 1994. View at Google Scholar · View at Scopus
  209. M. E. Tinetti and C. S. Williams, “Falls, injuries due to falls, and the risk of admission to a nursing home,” New England Journal of Medicine, vol. 337, no. 18, pp. 1279–1284, 1997. View at Publisher · View at Google Scholar · View at Scopus
  210. H. B. Menz, M. E. Morris, and S. R. Lord, “Foot and ankle characteristics associated with impaired balance and functional ability in older people,” Journals of Gerontology Series A, vol. 60, no. 12, pp. 1546–1552, 2005. View at Google Scholar · View at Scopus
  211. J. D. Moreland, J. A. Richardson, C. H. Goldsmith, and C. M. Clase, “Muscle weakness and falls in older adults: a systematic review and meta-analysis,” Journal of the American Geriatrics Society, vol. 52, no. 7, pp. 1121–1129, 2004. View at Publisher · View at Google Scholar · View at Scopus
  212. A. J. Campbell, M. C. Robertson, M. M. Gardner, R. N. Norton, M. W. Tilyard, and D. M. Buchner, “Randomised controlled trial of a general practice programme of home based exercise to prevent falls in elderly women,” British Medical Journal, vol. 315, no. 7115, pp. 1065–1069, 1997. View at Google Scholar · View at Scopus
  213. M. C. Robertson, N. Devlin, M. M. Gardner, and A. J. Campbell, “Effectiveness and economic evaluation of a nurse delivered home exercise programme to prevent falls. 1: randomised controlled trial,” British Medical Journal, vol. 322, no. 7288, pp. 697–701, 2001. View at Google Scholar · View at Scopus
  214. M. C. Robertson, A. J. Cambell, M. M. Gardner, and N. Devlin, “Preventing injuries in older adults by preventing falls: a meta-analysis of individual level data,” Journal of the American Geriatrics Society, vol. 50, pp. 905–911, 2002. View at Google Scholar
  215. L. Day, B. Fildes, I. Gordon, M. Fitzharris, H. Flamer, and S. Lord, “Randomised factorial trial of falls prevention among older people living in their own homes,” British Medical Journal, vol. 325, no. 7356, pp. 128–131, 2002. View at Google Scholar · View at Scopus
  216. M. E. Tinetti, “Preventing falls in elderly persons,” New England Journal of Medicine, vol. 348, no. 1, pp. 42–49, 2003. View at Publisher · View at Google Scholar · View at Scopus
  217. J. T. Chang, S. C. Morton, L. Z. Rubenstein et al., “Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials,” British Medical Journal, vol. 328, no. 7441, pp. 680–683, 2004. View at Google Scholar
  218. S. Gates, J. D. Fisher, M. W. Cooke, Y. H. Carter, and S. E. Lamb, “Multifactorial assessment and targeted intervention for preventing falls and injuries among older people in community and emergency care settings: systematic review and meta-analysis,” BMJ, vol. 336, no. 7636, pp. 130–133, 2008. View at Publisher · View at Google Scholar · View at Scopus
  219. O. J. De Vries, G. M. E. E. Peeters, P. J. M. Elders et al., “Multifactorial intervention to reduce falls in older people at high risk of recurrent falls: a randomized controlled trial,” Archives of Internal Medicine, vol. 170, no. 13, pp. 1110–1117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  220. K. M. Sanders, G. C. Nicholson, J. J. Watts et al., “Half the burden of fragility fractures in the community occur in women without osteoporosis. When is fracture prevention cost-effective?” Bone, vol. 38, no. 5, pp. 694–700, 2006. View at Publisher · View at Google Scholar · View at Scopus
  221. S. Kaptoge, L. I. Benevolenskaya, A. K. Bhalla et al., “Low BMD is less predictive than reported falls for future limb fractures in women across Europe: results from the European Prospective Osteoporosis Study,” Bone, vol. 36, no. 3, pp. 387–398, 2005. View at Publisher · View at Google Scholar
  222. T. Rikkonen, K. Salovaara, J. Sirola et al., “Physical activity slowsfemoral bone loss but promotes wrist fractures in postmenopausal women: a 15-year follow-up of the OSTPRE study,” Journal of Bone and Mineral Research, vol. 25, pp. 2332–2340, 2010. View at Google Scholar
  223. L. P. Fried, C. M. Tangen, J. Walston et al., “Frailty in older adults: evidence for a phenotype,” Journals of Gerontology Series A, vol. 56, no. 3, pp. M146–M156, 2001. View at Google Scholar · View at Scopus
  224. J. M. Guralnik, L. Ferrucci, E. M. Simonsick, M. E. Salive, and R. B. Wallace, “Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability,” New England Journal of Medicine, vol. 332, no. 9, pp. 556–561, 1995. View at Publisher · View at Google Scholar
  225. J. M. Guralnik, E. M. Simonsick, L. Ferrucci et al., “A short physical performance ba ttery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission,” Journal of Gerontology, vol. 49, pp. M85–M94, 1994. View at Google Scholar
  226. M. Cesari, C. Leeuwenburgh, F. Lauretani et al., “Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study,” American Journal of Clinical Nutrition, vol. 83, no. 5, pp. 1142–1148, 2006. View at Google Scholar · View at Scopus
  227. G. Crepaldi and S. Maggi, “Sarcopenia and osteoporosis: a hazardous duet,” Journal of Endocrinological Investigation, vol. 28, no. 10, supplement, pp. 66–68, 2005. View at Google Scholar
  228. Y. Rolland, G. Abellan Van Kan, A. Benetos et al., “Frailty, osteoporosis and hip fracture: causes, consequences and therapeutic perspectives,” Journal of Nutrition, Health and Aging, vol. 12, no. 5, pp. 335–346, 2008. View at Google Scholar · View at Scopus
  229. A. Frisoli, P. H. Chaves, S. J.M. Ingham, and L. P. Fried, “Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women: results from the Women's Health and Aging Study (WHAS) II,” Bone, vol. 48, no. 4, pp. 952–957, 2011. View at Publisher · View at Google Scholar