Journal of Osteoporosis / 2011 / Article / Fig 1

Review Article

Genotype-Phenotype Correlations in Autosomal Dominant Osteogenesis Imperfecta

Figure 1

Relationship between the positions of glycine substitutions in the triple helical domain of type I collagen and height z-scores in α1 chain of collagen I (a) and α2 chain of collagen I (b). The oblique solid line in B represents the regression line between the position of serine substitutions in α2 chain of collagen I and height (r = −0.73, P < 0.001; Spearman’s rank correlation). The oblique dashed line in (b) represents the regression line between the position of aspartate substitutions in α2 chain of collagen I and height (r = −0.75, P < 0.001). A mutation closer to the carboxy-terminal end of the triple helical domain of alpha 2 chain had a more detrimental effect on height (b). No such correlation was observed in the alpha 1 chain (a), adapted with some modification from [11].
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(a)
540178.fig.001b
(b)

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