Journal of Osteoporosis

Clinical Study

Genetic Influence of Candidate Osteoporosis Genes in Saudi Arabian Population: A Pilot Study

Table 1

(a) Demographic data of ALOX15 17p13 (rs7220870) of CC, CA, and AA alleles. (b) Statistical analysis of the ALOX15 17p13 (rs7220870) 3 alleles.
(a)
ParameterCC (138)CA (54)AA (8)
Age years 6 2 . 3 ± 5 . 7 5 9 . 9 4 ± 6 . 9 6 1 . 4 ± 1 1 . 5
BMD hip g/cm2 0 . 4 2 9 ± 0 . 1 0 . 4 6 8 ± 0 . 1 1 0 . 5 8 1 ± 0 . 2 6
T score − 2 . 8 ± 0 . 6 − 2 . 6 ± 0 . 9 − 2 ± 1 . 8
Z score − 1 . 6 ± 0 . 7 − 1 . 1 ± 0 . 9 − 0 . 7 4 ± 1 . 5
BMD spine g/cm2 0 . 6 8 0 ± 0 . 0 8 0 . 7 1 2 ± 0 . 1 2 0 . 6 6 2 ± 0 . 2 2
T score − 3 . 2 5 ± 0 . 9 − 3 . 0 7 ± 0 . 7 − 2 . 5 4 ± 1 . 2 2
Z score − 2 . 0 2 ± 0 . 6 8 − 1 . 8 1 ± 0 . 9 3 − 2 ± 0 .7
No. of fractures (%)39 (28.2)23 (42.6)4 (50)
(b)
ParameterAlleles 𝑃 value (CI)
AgeCC versus CA
CC + CA versus AA		0.002 (2.092–2.62)
0.8
BMD hip CC versus CA
CC + CA versus AA		0.001 (0.017–0.06)
0.001 (0.111–0.159)
BMD spineCC versus CA
CC + CA versus AA		0.002 (0.024–0.04)
0.01 (0.045–0.012)
History of fracturesCC versus CA
CC + CA versus AA		0.0002 (3.4–15.7)
0.001 (60.8–61.4)