Table of Contents Author Guidelines Submit a Manuscript
Journal of Osteoporosis
Volume 2012, Article ID 639427, 7 pages
http://dx.doi.org/10.1155/2012/639427
Research Article

Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats

1Bioquímica Investigación, Instituto de Investigación Sanitaria, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040 Madrid, Spain
2Internal Medicine, Instituto de Investigación, Sanitaria Fundación Jiménez Díaz, 28040 Madrid, Spain
3Trabeculae Technology Based Firm, Technological Park of Galicia, 32900 Ourense, Spain
4Traumatology and Orthopedic Surgery, University Hospital Complex of Santiago de Compostela, 15706 Santiago de Compostela, Spain
5Instituto Nacional de Endocrinología, 10400 La Habana, Cuba

Received 4 June 2012; Revised 1 August 2012; Accepted 11 September 2012

Academic Editor: Hope Weiler

Copyright © 2012 Mercedes Montero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “NIH Consensus development panel on osteoporosis prevention D and T. Osteoporosis prevention, diagnosis, and therapy,” Journal of the American Medical Association, vol. 285, pp. 785–795, 2001.
  2. R. Eastell, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Hoboken, NJ, USA, 5th edition, 2003.
  3. S. Srivastava, M. N. Weitzmann, S. Cenci, F. P. Ross, S. Adler, and R. Pacifici, “Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD,” Journal of Clinical Investigation, vol. 104, no. 4, pp. 503–513, 1999. View at Google Scholar · View at Scopus
  4. S. Srivastava, G. Toraldo, M. N. Weitzmann, S. Cenci, F. P. Ross, and R. Pacifici, “Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation,” Journal of Biological Chemistry, vol. 276, no. 12, pp. 8836–8840, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Kousteni, L. Han, J. R. Chen et al., “Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids,” Journal of Clinical Investigation, vol. 111, no. 11, pp. 1651–1664, 2003. View at Google Scholar · View at Scopus
  6. M. N. Weitzmann and R. Pacifici, “Estrogen deficiency and bone loss: an inflammatory tale,” Journal of Clinical Investigation, vol. 116, no. 5, pp. 1186–1194, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Basu, K. Michaëlsson, H. Olofsson, S. Johansson, and H. Melhus, “Association between oxidative stress and bone mineral density,” Biochemical and Biophysical Research Communications, vol. 288, no. 1, pp. 275–279, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Maggio, M. Barabani, M. Pierandrei et al., “Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 4, pp. 1523–1527, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Muthusami, I. Ramachandran, B. Muthusamy et al., “Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats,” Clinica Chimica Acta, vol. 360, no. 1-2, pp. 81–86, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. M. C. Polidori, W. Stahl, O. Eichler, I. Niestroj, and H. Sies, “Profiles of antioxidants in human plasma,” Free Radical Biology and Medicine, vol. 30, no. 5, pp. 456–462, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Rahman, “Studies on free radicals, antioxidants, and co-factors,” Clinical Interventions in Aging, vol. 2, no. 2, pp. 219–236, 2007. View at Google Scholar · View at Scopus
  12. J. M. Lean, C. J. Jagger, B. Kirstein, K. Fuller, and T. J. Chambers, “Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation,” Endocrinology, vol. 146, no. 2, pp. 728–735, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. G. N. Schrauzer, “Anticarcinogenic effects of selenium,” Cellular and Molecular Life Sciences, vol. 57, no. 13-14, pp. 1864–1873, 2000. View at Google Scholar · View at Scopus
  14. G. P. Trueba, G. M. Sánchez, and A. Giuliani, “Oxygen free radical and antioxidant defense mechanism in cancer,” Frontiers in Bioscience, vol. 9, pp. 2029–2044, 2004. View at Google Scholar · View at Scopus
  15. R. Moreno-Reyes, D. Egrise, J. Nève, J. L. Pasteels, and A. Schoutens, “Selenium deficiency-induced growth retardation is associated with an impaired bone metabolism and osteopenia,” Journal of Bone and Mineral Research, vol. 16, no. 8, pp. 1556–1563, 2001. View at Google Scholar · View at Scopus
  16. M. Kleerekoper, “Osteoporosis prevention and therapy: preserving and building strength through bone quality,” Osteoporosis International, vol. 17, no. 12, pp. 1707–1715, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Goltzman, “Discoveries, drugs and skeletal disorders,” Nature Reviews Drug Discovery, vol. 1, no. 10, pp. 784–796, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Vestergaard, N. R. Jorgensen, L. Mosekilde, and P. Schwarz, “Effects of parathyroid hormone alone or in combination with antiresorptive therapy on bone mineral density and fracture risk—a meta-analysis,” Osteoporosis International, vol. 18, no. 1, pp. 45–57, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. P. J. Meunier, D. O. Slosman, P. D. Delmas et al., “Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis—a 2-year randomized placebo controlled trial,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 5, pp. 2060–2066, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. S. C. Chai, C. I. Wei, K. Brummel-Smith, and B. H. Arjmandi, “The role of vitamin E in reversing bone loss,” Aging Clinical and Experimental Research, vol. 20, no. 6, pp. 521–527, 2008. View at Google Scholar · View at Scopus
  21. Z. Yang, Z. Zhang, K. L. Penniston, N. Binkley, and S. A. Tanumihardjo, “Serum carotenoid concentrations in postmenopausal women from the United States with and without osteoporosis,” International Journal for Vitamin and Nutrition Research, vol. 78, no. 3, pp. 105–111, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. C. L. Shen, P. Wang, J. Guerrieri, J. K. Yeh, and J. S. Wang, “Protective effect of green tea polyphenols on bone loss in middle-aged female rats,” Osteoporosis International, vol. 19, no. 7, pp. 979–990, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. C.-L. Shen, J. K. Yeh, J. J. Cao, and J.-S. Wang, “Green tea and bone metabolism,” Nutrition Research, vol. 29, no. 7, pp. 437–456, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. D. J. Morton, E. L. Barrett-Connor, and D. L. Schneider, “Vitamin C supplement use and bone mineral density in postmenopausal women,” Journal of Bone and Mineral Research, vol. 16, no. 1, pp. 135–140, 2001. View at Google Scholar · View at Scopus
  25. M. D. Curiel, J. A. Calero, R. Guerrero, J. Gala, R. Gazapo, and C. De la Piedra, “Effects of LY-117018 HCl on bone remodeling and mineral density in the oophorectomized rat,” American Journal of Obstetrics and Gynecology, vol. 178, no. 2, pp. 320–325, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. A. González, Antioxidants: Study and Applications, Internal Editions of Catalysis Laboratories, 2005.
  27. J. G. Paniagua, M. Díaz-Curiel, C. De La Piedra Gordo, C. C. Reparaz, and M. T. García, “Bone mass assessment in rats by dual energy X-ray absorptiometry,” British Journal of Radiology, vol. 71, pp. 754–758, 1998. View at Google Scholar · View at Scopus
  28. I. A. Feldkamp, L. C. Davis, and J. W. Kress, “Practical cone-beam algorithm,” Journal of the Optical Society of America A, vol. 1, no. 6, pp. 612–619, 1984. View at Google Scholar · View at Scopus
  29. T. Hildebrand and P. Rüegsegger, “A new method for the model-independent assessment of thickness in three-dimensional images,” Journal of Microscopy, vol. 185, no. 1, pp. 67–75, 1997. View at Google Scholar · View at Scopus
  30. D. Ulrich, B. Van Rietbergen, A. Laib et al., “The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone,” Bone, vol. 25, no. 1, pp. 55–60, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Hahn, M. Vogel, M. Pompesius-Kempa, and G. Delling, “Trabecular bone pattern factor—a new parameter for simple quantification of bone microarchitecture,” Bone, vol. 13, no. 4, pp. 327–330, 1992. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Hernández and D. Vargas, “Utilidad de Diamel en pacientes con dibetes mellitus tipo 2 en tratmiento combinado con glibenclamida,” Avances en Diabetología, vol. 23, pp. 49–55, 2007. View at Google Scholar
  33. A. F. Stewart, R. L. Cain, D. B. Burr, D. Jacob, C. H. Turner, and J. M. Hock, “Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: a comparison of human parathyroid hormone 1–34, parathyroid hormone-related protein 1–36, and SDZ- parathyroid hormone 893,” Journal of Bone and Mineral Research, vol. 15, no. 8, pp. 1517–1525, 2000. View at Google Scholar · View at Scopus
  34. R. G. Erben, J. Eberle, K. Stahr, and M. Goldberg, “Androgen deficiency induces high turnover osteopenia in aged male rats: a sequential histomorphometric study,” Journal of Bone and Mineral Research, vol. 15, no. 6, pp. 1085–1098, 2000. View at Google Scholar · View at Scopus
  35. M. Kneissel, A. Boyde, and J. A. Gasser, “Bone tissue and its mineralization in aged estrogen-depleted rats after long-term intermittent treatment with parathyroid hormone (PTH) analog SDZ PTS 893 or human PTH(1–34),” Bone, vol. 28, no. 3, pp. 237–250, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. J. P. Rissanen, M. I. Suominen, Z. Peng et al., “Short-term changes in serum PINP predict long-term changes in trabecular bone in the rat ovariectomy model,” Calcified Tissue International, vol. 82, no. 2, pp. 155–161, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. J. P. Rissanen, M. I. Suominen, Z. Peng, and J. M. Halleen, “Secreted tartrate-resistant acid phosphatase 5b is a marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model,” Calcified Tissue International, vol. 82, no. 2, pp. 108–115, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. D. Tsavachidou, T. J. McDonnell, S. Wen et al., “Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer,” Journal of the National Cancer Institute, vol. 101, no. 5, pp. 306–320, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. E. Vilar Gomez, A. Rodriguez De Miranda, B. Gra Oramas et al., “Clinical trial: a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver disease,” Alimentary Pharmacology and Therapeutics, vol. 30, no. 10, pp. 999–1009, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. D. Uddin and M. A. M. I. Islam, “Findings of the 3-month supportive treatment with oncoxin solution beside the standard modalities of patients with different neoplastic diseases,” TAJ, vol. 22, pp. 172–175, 2009. View at Google Scholar
  41. E. V. Gomez, Y. M. Perez, H. V. Sanchez et al., “Antioxidant and immunomodulatory effects of Viusid in patients with chronic hepatitis C,” World Journal of Gastroenterology, vol. 16, no. 21, pp. 2638–2647, 2010. View at Publisher · View at Google Scholar · View at Scopus