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Journal of Osteoporosis
Volume 2013 (2013), Article ID 325693, 5 pages
http://dx.doi.org/10.1155/2013/325693
Research Article

Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of Its Background

1Department of Traumatology and Orthopedics and Battle Field Surgery, Kursk State Medical University, Karl Marx Street, Kursk 305 004, Russia
2Department of Clinical Pharmacology, Kursk State Medical University, Karl Marx Street, Kursk 305 004, Russia
3Department of Pharmacology, Kursk State Medical University, Karl Marx Street, Kursk 305 004, Russia
4Department of Histology, Cytology and Embryology, Kursk State Medical University, Karl Marx Street, Kursk 305 004, Russia

Received 30 September 2012; Revised 1 December 2012; Accepted 19 December 2012

Academic Editor: Jun Iwamoto

Copyright © 2013 D. S. R. Rajkumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the experiment on the white Wistar female rats (222 animals), the osteoprotective effect of enalapril and losartan was studied on experimental models of osteoporosis and osteoporotic fractures. It was revealed that in rats after ovariectomy, the endothelial dysfunction of microcirculation vessels of osteal tissue develops, resulting in occurrence of osteoporosis and delay of consolidation of experimental fractures. Enalapril and losartan prevented the reduction of microcirculation in bone, which was reflected in slowing the thinning of bone trabeculae and in preventing the occurrence of these microfractures, as well as increasing quality of experimental fractures healing.